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Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial

Authors

  • Keyvan Karkouti Department of Anesthesia and Institute of Health Policy, Management, and Evaluation, University of Toronto, Toronto, Ontario, Canada Peter Munk Cardiac Centre and Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Jeannie Callum Department of Clinical Pathology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Vivek Rao Peter Munk Cardiac Centre and Toronto General Research Institute, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada Division of Cardiovascular Surgery, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Nancy Heddle Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Michael E Farkouh Peter Munk Cardiac Centre and Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Mark A Crowther Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Damon C Scales Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada Interdepartmental Division of Critical Care and Department of Medicine, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Keyvan Karkouti; keyvan.karkouti{at}uhn.ca
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Citation

Karkouti K, Callum J, Rao V, et al
Protocol for a phase III, non-inferiority, randomised comparison of a new fibrinogen concentrate versus cryoprecipitate for treating acquired hypofibrinogenaemia in bleeding cardiac surgical patients: the FIBRES trial

Publication history

  • Received November 21, 2017
  • Revised February 22, 2018
  • Accepted March 20, 2018
  • First published April 20, 2018.
Online issue publication 
April 20, 2018

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