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  • Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study

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Genetics and genomics
Research
Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study
  1. Simin Wen1,
  2. Yanhua Wu1,
  3. Yuchen Pan1,
  4. Mengzhuo Cao2,3,
  5. Dan Zhao1,
  6. Chong Wang4,
  7. Chuan Wang5,
  8. Fei Kong4,
  9. Jie Li2,
  10. Junqi Niu4,
  11. Jing Jiang1
  1. 1 Department of Clinical Research, First Hospital of Jilin University, Changchun, China
  2. 2 Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China
  3. 3 Division of Education, Beijing Jishuitan Hospital, Beijing, China
  4. 4 Department of Hepatology, First Hospital of Jilin University, Changchun, China
  5. 5 Department of Child Healthcare, Maternal and Child Health Care and Family Planning Service Center of Chaoyang District, Beijing, China
  1. Correspondence to Dr Jing Jiang; jiangjing19702000{at}jlu.edu.cn

Abstract

Objectives To investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).

Design Nested case–control study.

Setting Changchun, China.

Participants 713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(–) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.

Results Infants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene–gene interaction was found between IL-10 and IL-10RA.

Conclusions Our study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(–) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies.

  • hepatobiliary disease
  • infectious diseases
  • genetics
  • immunology

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2018-022334

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    Footnotes

    • SW and YW contributed equally.

    • Contributors JJ, JN and JL designed the study. SW, YP, MC, DZ, ChoW, ChuW and FK collected human samples and clinical data. SW detected the HBsAg and anti-HBs. SW and YW conducted the statistical analysis of the data and wrote the paper.

    • Funding This study was supported by the National Major Scientific and Technological Special Project during the 13th Five-year Plan Period (2017ZX1020120100301), Health Research Project of Jilin Province (2015Z003) and China Hepatitis Prevention Foundation Project (TIAN QING Liver Disease foundation, TQGB20140137).

    • Competing interests None declared.

    • Patient consent Parental/guardian consent obtained.

    • Ethics approval This study was approved by the Medical Ethics Committee of the First Hospital of Jilin University.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement No additional data are available.