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Combining CD4 recovery and CD4: CD8 ratio restoration as an indicator for evaluating the outcome of continued antiretroviral therapy: an observational cohort study
  1. Shui Shan Lee1,
  2. Ngai Sze Wong1,2,
  3. Bonnie Chun Kwan Wong3,
  4. Ka Hing Wong3,
  5. Kenny Chi Wai Chan3
  1. 1 Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China
  2. 2 Institute for Global Health and Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
  3. 3 Centre for Health Protection, Department of Health, Hong Kong Special Administrative Region Government, Hong Kong, China
  1. Correspondence to Dr Ngai Sze Wong; candy_wong{at}cuhk.edu.hk

Abstract

Objectives Immune recovery following highly active antiretroviral therapy (HAART) is commonly assessed by the degree of CD4 reconstitution alone. In this study, we aimed to assess immune recovery by incorporating both CD4 count and CD4:CD8 ratio.

Design Observational cohort study

Setting and participants Clinical data from Chinese HIV-positive patients attending the largest HIV service in Hong Kong and who had been on HAART for ≥4 years were accessed.

Main outcome measures Optimal immune outcome was defined as a combination of a CD4 count ≥500/μL and a CD4:CD8 ratio ≥0.8.

Results A total of 718 patients were included for analysis (6353 person-years). At the end of year 4, 318 out of 715 patients achieved CD4 ≥500/μL, of which only 33% (105 out of 318) concurrently achieved CD4:CD8 ratio ≥0.8. Patients with a pre-HAART CD8 ≤800/μL (428 out of 704) were more likely to be optimal immune outcome achievers with CD4 ≥500/μL and CD4:CD8 ratio ≥0.8, the association of which was stronger after adjusting for pre-HAART CD4 counts. In a multivariable logistic model, optimal immune outcome was positively associated with male gender, younger pre-HAART age and higher pre-HAART CD4 count, longer duration of HAART and pre-HAART CD8 ≤800/μL. Treatment regimen and cumulative viral loads played no significant role in the pattern of immune recovery.

Conclusions A combination of CD4 count and CD4:CD8 ratio could be a useful approach for the characterisation of treatment outcome over time, on top of monitoring CD4 count alone.

  • antiretroviral therapy
  • CD4
  • CD8
  • CD4:CD8 ratio
  • immune outcome

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

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Footnotes

  • Contributors SSL motivated and designed the study. KHW, BCKW and KCWC contributed the data and their interpretation. NSW analysed the data. SSL wrote the article. All authors contributed to interpretation of results and critically reviewed and edited the article.

  • Funding The study was supported by Health and Medical Research Fund (Project code: CU-15-A15) of the Food and Health Bureau, Hong Kong Special Administrative Region Government. The funder did not have any role in study design, analysis and interpretation of data, and drafting the manuscript.

  • Disclaimer The opinions and assertions contained herein are private views of the authors and do not necessarily reflect those of the Centre for Health Protection, Hong Kong Special Administrative Region Government Department of Health, or the other affiliating institutions.

  • Competing interests None declared.

  • Ethics approval The Joint Chinese University of Hong Kong–New Territories East Cluster Clinical Research Ethics Committee (CREC).

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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