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Predictors of discharge destination from acute care in patients with traumatic brain injury
  1. Sareh Zarshenas1,2,
  2. Laetitia Tam2,
  3. Angela Colantonio1,2,
  4. Seyed Mohammad Alavinia3,
  5. Nora Cullen1,2
  1. 1 Rehabilitation Sciences Institute, University of Toronto, Toronto, Canada
  2. 2 University Health Network-Toronto Rehabilitation Institute-University Centre, Toronto, Canada
  3. 3 University Health Network-Toronto Rehabilitation Institute-Lyndhurst Centre, Toronto, Canada
  1. Correspondence to Sareh Zarshenas; sareh.zarshenas{at}


Introduction Many studies have assessed the predictors of morbidity/mortality of patients with traumatic brain injury (TBI) in acute care. However, with the increasing rate of survival after TBI, more attention has been given to discharge destinations from acute care as an important measure of clinical priorities. This study describes the design of a systematic review compiling and synthesising studies on the prognostic factors of discharge settings from acute care in patients with TBI.

Methods and analysis This systematic review will be conducted on peer-reviewed studies using seven databases including Medline/Medline in-Process, Embase, Cochrane Database of Systematic Reviews, Cochrane CENTRAL, PsycINFO, CINAHL and Supplemental PubMed. The reference list of selected articles and Google Scholar will also be reviewed to determine other relevant articles. This study will include all English language observational studies that focus on adult patients with TBI in acute care settings. The quality of articles will be assessed by the Quality in Prognostic Studies tool.

Ethics and dissemination The results of this review will provide evidence that may guide healthcare providers in making more informed and timely discharge decisions to the next level of care for patient with TBI. Also, this study will provide valuable information to address the gaps in knowledge for future research.

Trial registration number Trial registration number (PROSPERO) is CRD42016033046.

  • brain injuries
  • patient discharge
  • healthcare

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  • Contributors SZ developed the idea and designed the protocol with oversight from NC and AC. SZ and LT reviewed all articles. NC and AC provided advice on each level of review. NC, AC and SMA helped in revising the manuscript critically. SMA provided advice on methodology of synthesis and analysis of the findings. All authors gave final approval of this manuscript.

  • Funding This research received no specific grant from any funding agency in the public, commercial or not-for- profit sectors. SZ was supported by a Toronto Rehabilitation Institute Scholarship for graduate students (2016/17), and AC was supported by a Canadian Institutes of Health Research Research Chair in Gender, Work and Health (#CGW-126580).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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