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Diagnosis and treatment for hyperuricaemia and gout: a protocol for a systematic review of clinical practice guidelines and consensus statements
  1. Qianrui Li1,
  2. Xiaodan Li2,
  3. Joey Sum-Wing Kwong3,4,5,
  4. Hao Chen6,
  5. Xin Sun5,
  6. Haoming Tian1,
  7. Sheyu Li1
  1. 1 Department of Endocrinology and Metabolism 610041, West China Hospital, Sichuan University, Chengdu, China
  2. 2 Department of Gastroenterology 610041, West China Hospital, Sichuan University, Chengdu, China
  3. 3 Cochrane Taiwan 11031, Taipei Medical University, Taipei, Taiwan
  4. 4 Department of Clinical Epidemiology and Department of Health Policy 157-8535, National Center for Child Health and Development, Tokyo, Japan
  5. 5 Chinese Evidence-based Medicine Center 610041, West China Hospital, Sichuan University, Chengdu, China
  6. 6 The Second Clinical College 210046, Nanjing University of Chinese Medicine, Nanjing, China
  1. Correspondence to Haoming Tian; hmtian999{at} and Dr Sheyu Li; lisheyu{at}


Introduction Gout and hyperuricaemia are major health issues and relevant guidance documents have been released by a variety of national and international organisations. However, these documents contain inconsistent recommendations with unclear quality profiles. We aim to conduct a systematic appraisal of the clinical practice guidelines and consensus statements pertaining to the diagnosis and treatment for hyperuricaemia and gout, and to summarise recommendations.

Methods We will search PubMed, EMBASE and guideline databases to identify published clinical practice guidelines and consensus statements. We will search Google and Google Scholar for additional potentially eligible documents. The quality of included guidelines and consensus statements will be assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument and be presented as scores. We will also manually extract recommendations for clinical practice from all included documents.

Ethics and dissemination The results of this systematic review will be disseminated through relevant conferences and peer-reviewed journals.

Protocol registration number PROSPERO CRD42016046104.

  • Clinical practice guideline
  • Hyperuricemia
  • Gout
  • Systematic review

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  • Contributors HT and SL conceived this study. QL, JSWK and SL designed the inclusion/exclusion criteria and the searching resource and strategy. QL, JSWK, HC and XS designed the appraisal strategy of each included guideline and consensus. QL, XL and SL drafted the protocol. All authors discussed actively in the protocol of the study.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement This manuscript is a protocol of a systematic review and does not contain original data.

  • Correction notice This paper has been amended since it was published Online First. Owing to a scripting error, some of the publisher names in the references were replaced with 'BMJ Publishing Group'. This only affected the full text version, not the PDF. We have since corrected theseerrors and the correct publishers have been inserted into the references.

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