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Geriatric medicine
Protocol
The incidence of delirium after cardiac surgery in the elderly: protocol for a systematic review and meta-analysis
  1. Yulin Liao1,
  2. Joseph H Flaherty2,
  3. Jirong Yue3,
  4. Yanyan Wang1,
  5. Chuanyao Deng1,
  6. Ling Chen1
  1. 1Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China
  2. 2Division of Geriatrics, Department of Internal Medicine, Saint Louis University, St Louis, Missouri, USA
  3. 3Department of Geriatrics, West China Hospital, Sichuan University, The National Center for Geriatric Clinical Research in West China Hospital, Chengdu, Sichuan, China
  1. Correspondence to Dr Jirong Yue; yuejirong11{at}hotmail.com

Abstract

Introduction Delirium is one of the most common complications after cardiac surgery in the elderly. Future studies aimed at preventing postoperative delirium will need an accurate estimate of incidence. However, there are no available systematic reviews on the incidence, and reports of incidence of postoperative delirium after a cardiac operation vary widely with significant heterogeneity. Therefore, we aim to perform a systematic review and meta-analysis to determine the most accurate incidence possible of postoperative delirium in individuals aged >65 years after cardiac surgery.

Methods and analyses We will undertake a comprehensive literature search among PubMed, EMBASE, the Cochrane Library, PsycINFO and CINAHL, from their inception to January 2017. Prospective cohort and cross sectional studies that described the incidence of delirium will be eligible for inclusion. The primary outcome will be the incidence of delirium. Risk of bias and methodological quality for the included studies will be assessed using a risk of bias tool for prevalence studies and the Cochrane guidelines. Heterogeneity of the estimates across studies will be assessed. Incidence data will be pooled by selective or emergency surgery. This systematic review will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA).

Ethics and dissemination This proposed systematic review and meta-analysis is based on published data, and thus there is no requirement for ethics approval. The study will provide an up to date and accurate incidence of postoperative delirium among the older population after cardiac surgery, which is necessary for future research in this area. The findings of this study will be presented at conferences and disseminated through publication in a peer reviewed journal.

Trial registration number CRD42016047773.

  • delirium
  • systematic review and meta-analysis
  • incidence
  • protocol
  • elderly

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-014726

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    Footnotes

    • Contributors YL and JY conceived and designed the protocol, and YL drafted the protocol manuscript. JHF and JY critically revised the manuscript for methodological and intellectual content. YW participated in the development of the search strategy. CD and LC planned the data extraction. All authors approved the final version.

    • Competing interests None declared.

    • Ethics approval Given that this is a protocol for a systematic review and based on published data, there is no requirement for ethics approval.

    • Provenance and peer review Not commissioned; externally peer reviewed.