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Mental health
Research
Fruit and vegetable consumption and psychological distress: cross-sectional and longitudinal analyses based on a large Australian sample
  1. Binh Nguyen,
  2. Ding Ding,
  3. Seema Mihrshahi
  1. Prevention Research Collaboration, Sydney School of Public Health, The University of Sydney, Camperdown, New South Wales, Australia
  1. Correspondence to Ms Binh Nguyen; thanh-binh.nguyen-duy{at}sydney.edu.au

Abstract

Objectives Growing evidence suggests a link between diet and mental health. This study aimed to investigate the association between fruit and vegetable consumption and the prevalence and incidence of psychological distress in middle-aged and older Australians.

Design Cross-sectional and prospective.

Setting New South Wales, Australia.

Methods A sample of 60 404 adults aged ≥45 years completed baseline (2006–2008) and follow-up (2010) questionnaires. Psychological distress was assessed at baseline and follow-up using the validated Kessler Psychological Distress Scale (K10), a 10-item questionnaire measuring general anxiety and depression. Psychological distress was defined as the presence of high-to-very high levels of distress (K10 score ≥22). Usual fruit and vegetable consumption was assessed using short validated questions. The association between baseline fruit and vegetable consumption and the prevalence or incidence of psychological distress was examined using logistic regression models.

Results At baseline, 5.6% reported psychological distress. After a mean 2.7 years of follow-up, 4.0% of those who did not report distress at baseline reported distress at follow-up. Baseline fruit and vegetable consumption considered separately or combined, was associated with a lower prevalence of psychological distress even after adjustment for sociodemographic characteristics and lifestyle risk factors. Baseline fruit and vegetable consumption, measured separately or combined, was associated with a lower incidence of psychological distress in minimally adjusted models. Most of these associations remained significant at medium levels of intake but were no longer significant at the highest intake levels in fully adjusted models.

Conclusions Increasing fruit and vegetable consumption may help reduce psychological distress in middle-aged and older adults. However, the association of fruit and vegetable consumption with the incidence of psychological distress requires further investigation, including the possibility of a threshold effect between medium and higher consumption levels.

  • MENTAL HEALTH
  • NUTRITION & DIETETICS

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-014201

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    Strengths and limitations of this study

    • This study included a large sample size of 60 404 participants for cross-sectional analyses and 54 345 participants for longitudinal analyses.

    • Analyses were adjusted for multiple sociodemographic and lifestyle-related covariates.

    • The well-validated Kessler Psychological Distress Scale (K10) was used to assess psychological distress.

    • The relatively short follow-up time may have been insufficient to observe the full extent of long-term associations between fruit and vegetable intake and psychological distress.

    Introduction

    There has been a global call for action by the WHO to make mental health a global development priority.1 Mental disorders affect a 10th of the world population and represent 30% of non-fatal global burden of disease.2 Depression alone is a leading cause of disability worldwide3 and is projected to rank among the three leading causes of global disease burden by 2030.4 There is an urgent call for public health strategies aimed at preventing the onset on common mental disorders, such as depression.

    There has been considerable interest in the relationship between psychological well-being and lifestyle factors, with growing evidence for a link between mental health and diet.5–7 The role of fruit and vegetables has received increasing attention, given evidence for its protective effects against chronic diseases such as cardiovascular disease and cancer.8 ,9 Diets low in fruit have been recently identified as the leading dietary risk factor for global burden of disease.10

    Findings from a recent meta-analysis, based on seven cross-sectional and four prospective studies, suggest that both fruit and vegetable consumption are significantly associated with a lower risk of depression.11 Several large cross-sectional studies have shown that greater consumption of fruit and vegetables is associated with better mental health, including lower odds of depression and psychological distress, in the general population.12–14 Fewer studies have investigated the longitudinal association between fruit and vegetable intake and depression. Higher consumption of fruit and/or vegetables was associated with lower odds of incident depression in middle-aged Australian women followed over 6 years,15 postmenopausal American women followed for 3 years16 and Spanish adults followed over 4 years.17 These findings are in agreement with previous cross-sectional and longitudinal studies that have found healthy dietary patterns, including high intakes of fruit and vegetables, to be associated with a lower risk of depression and anxiety, particularly in middle-aged and older adults.18–21

    Depression in later life is associated with increased morbidity and mortality, and decreased physical, cognitive and social functioning.22 Improving mental health is an important public health challenge to address in an ageing population with a higher life expectancy.1 Therefore, the main objective of this study was to investigate the association between fruit and vegetable consumption and the prevalence and incidence of psychological distress in a large cohort of middle-aged and older Australians.

    Methods

    Study population

    The baseline data were from the Sax Institute's 45 and Up Study, a large-scale (n=267 153) population study of men and women aged 45 years and over, who were randomly sampled from the general population of New South Wales (NSW), Australia. From January 2006 to December 2008, eligible individuals joined the study by completing a postal questionnaire and providing written consent for participation and long-term follow-up. The 45 and Up Study has been described in detail elsewhere.23 A subsample of the 45 and Up Study was followed up in 2010 (ie, the Social, Economic, and Environmental Factor (SEEF) Study), with the first 100 000 participants of the 45 and Up Study invited to complete the SEEF questionnaire (60.4% response rate). A participant flow chart for this study is provided in figure 1. For cross-sectional analyses at baseline, the analytic sample included 60 404 participants (53.6% women). For longitudinal analyses, participants who reported on the baseline questionnaire that they had been treated for depression/anxiety in the previous month (n=3796), and/or taking antidepressant medication for most of the past 4 weeks (n=700), and/or with high/very high levels of psychological distress (n=3030; defined as having a Kessler Psychological Distress Scale (K10) score ≥2224 were excluded (n=6067), leaving a final sample of 54 345 participants.

    Figure 1
    Figure 1

    Participant flow chart. SEEF, Social, Economic, and Environmental Factor.

    Measurement

    The 45 and Up Study and SEEF Study questionnaires include questions on sociodemographic characteristics, personal and medical history, and lifestyle risk factors (available from http://www.saxinstitute.org.au/our-work/45-up-study/questionnaires/).

    Outcome

    At both baseline and follow-up, participants' general level of psychological distress was assessed using the well-validated and widely used K10, a 10-item questionnaire about anxiety and depression symptoms experienced in the past 4 weeks.24 A five-point response scale (none of the time, a little of the time, some of the time, most of the time, all of the time) is used for each item, with scores ranging from 1 (none of the time) to 5 (all of the time). Scores to each question are added up to form the total K10 score, with a possible range of 10–50. For this study, score groupings and categories of psychological distress routinely used by the Australian Bureau of Statistics for national health surveys were adopted with total scores of: 10–15, 16–21, 22–29 and 30–50 indicating low, moderate, high and very high levels of psychological distress, respectively.

    High K10 scores are strongly correlated with current WHO's Composite International Diagnostic Interview (CIDI) diagnosis of anxiety and affective disorders.24 Prevalence of psychological distress at baseline was defined as the presence of high-to-very high levels of psychological distress (K10 score ≥22). Incidence of psychological distress was defined as: (1) not being treated for anxiety/depression in the previous month, and/or not taking antidepressant medication for most of the past 4 weeks, and/or not having high/very high levels of psychological distress (K10 score <22) at baseline, and (2) the presence of high-to-very high levels of psychological distress (K10 score ≥22) at follow-up. Psychological distress was treated as binary outcome variable in the analyses (K10 score <22 vs ≥22; ie, low-to-moderate vs high-to-very high levels of distress).

    Exposure

    Usual fruit and vegetable consumption was assessed at baseline using the following validated short questions commonly used in health monitoring and surveillance:25

    1. ‘About how many serves of fruit do you usually have each day?’ One serve of fruit was defined as one medium piece or two small pieces of fresh fruit, or one cup of diced or canned fruit pieces.

    2. ‘About how many serves of vegetables do you usually eat each day?’ One serve of vegetables was defined as half a cup of cooked vegetables (including potatoes) or one cup of raw vegetables (eg, salad).

    Total fruit and vegetable consumption was derived by summing the reported number of fruit and vegetables consumed daily. Fruit and vegetable consumption, considered separately and combined, was categorised into tertiles. Using quantiles ensures that the range in exposure is captured evenly across distribution categories, which facilitates comparison between different levels of fruit and vegetable consumption among the study cohort, and has been previously used in another large cohort study.16

    Covariates

    Covariates included baseline self-reported sociodemographic characteristics such as sex, age, highest level of education (≤10 years of schooling, high school/trade apprenticeship/certificate/diploma, university degree/higher), marital status (married/living with a partner vs single/widowed/divorced/separated), household annual income (<$30 000, $30 000−$69 999, ≥$70 000, would rather not answer this question), self-reported history of major chronic disease (cancer other than non-melanoma skin cancer, cardiovascular disease (heart disease, stroke or blood clot), diabetes or hypertension; yes vs no) and the following lifestyle risk factors: body mass index (BMI; derived from self-reported height and weight; defined as underweight ((<18.5 kg/m2), normal weight (18.5 to <25 kg/m2), overweight/obese (≥25 kg/m2)), alcohol intake (≤14 or >14 drinks/week), smoking status (current regular smoker vs not currently a regular smoker) and physical activity levels (assessed using validated questions from the Active Australia Survey;26 categorised as <150, 150–299 and ≥300 min/week).

    Statistical analysis

    The association between baseline fruit and vegetable consumption and the prevalence/incidence of psychological distress (K10 score ≥22) was examined using logistic regression models. ORs with 95% CIs are presented for unadjusted, age-adjusted and sex-adjusted, and models adjusted for all covariates as described above. We tested effect modification by sex by fitting interaction terms. To examine potential sex differences, the analyses were further stratified by sex. If 1 out of 10 responses to K10 questions was missing (for 3.2% and 2.8% of participants included in cross-sectional and longitudinal analyses, respectively), the missing value was imputed using the mean score across the other 9 questions.27 If more than one response was missing, K10 scores were considered as missing. p Values <0.05 were considered statistically significant. All analyses were conducted using SPSS V.22 (IBM Corp, Armonk, New York, USA).

    Results

    Participant characteristics

    Table 1 shows baseline participant characteristics based on K10 score at follow-up. Overall, the mean age (SD) of participants was 62.2 (10.6) years, more than half (53.6%) were women, over a quarter (26%) had a university degree/higher, over three-quarters (78%) were in a married/de facto relationship, and a quarter (25.7%) reported a household annual income ≥$70 000. The mean (SD) serves of fruit and vegetables were, respectively, 2.0 (1.4) and 3.9 (2.6) serves/day. The average follow-up time period was 2.7 (0.9) years. Compared with men, women were more likely to be younger, less educated, single/widowed/divorced/separated, have a lower household annual income, a lower BMI, and to consume more fruit and vegetables and less alcohol. Participants with high-to-very high levels of psychological distress (5.6%) at baseline were more likely to be women, relatively younger, less educated and have a lower household annual income. These participants were also more likely to: have a higher BMI, be a current smoker, be less physically active and have a history of chronic disease.

    View this table:
    Table 1

    Baseline characteristics of participants according to sex and K10 score at baseline (n=60 404; 2006–2010)*

    Prevalence of psychological distress

    The ORs for the association between separate or combined fruit and vegetable consumption and the prevalence of high-to-very high levels of psychological distress (K10≥22) are presented in table 2. Consumption of fruit and vegetables, considered separately or combined, was consistently associated with a lower prevalence of psychological distress. Following adjustment for all covariates, these associations were slightly attenuated compared with the unadjusted model but remained significant. Other covariates which were significantly associated with the prevalence of psychological distress were being relatively younger, single/divorced/widowed/separated, a current smoker, lower education, lower household annual income, lower BMI, low physical activity levels and a self-reported history of chronic disease. There was a significant interaction between combined fruit and vegetable consumption and sex (p=0.049). When analyses were stratified by sex (table 3), the association between fruit and vegetable consumption, measured separately or combined, and the prevalence of psychological distress was markedly stronger in women and was significant for all consumption tertiles (p≤0.001). Among men, only those in the medium tertiles of separate fruit and vegetable consumption had significantly lower odds of psychological distress.

    View this table:
    Table 2

    Unadjusted and adjusted ORs for the baseline association between fruit and vegetable consumption and the prevalence of high-to-very high levels of psychological distress (K10*≥22 vs K10*<22; n=60 404)

    View this table:
    Table 3

    Adjusted ORs for the prevalence and incidence of high-to-very high levels of psychological distress (K10*≥22 vs K10*<22) by baseline fruit and vegetable consumption and stratified by sex

    Incidence of psychological distress

    After an average of 2.7 years of follow-up, 4.0% of those who did not report distress at baseline reported distress at follow-up. Table 4 shows the association between fruit and vegetable consumption and the incidence of high-to-very high levels of psychological distress (K10≥22). Similar to cross-sectional findings, fruit and vegetable consumption, measured separately or combined, was significantly associated with a lower incidence of psychological distress in unadjusted and minimally adjusted models. In the fully adjusted models, the medium tertiles of combined fruit and vegetable consumption, and separate vegetable consumption, remained significantly associated with reduced odds of psychological distress. The association between the medium tertile of fruit consumption and the incidence of psychological distress approached significance (p=0.07). However, the association between the highest tertile of consumption and the incidence of psychological distress did not remain significant for consumption of fruit and vegetables considered either separately or combined. Other covariates which were significantly associated with the incidence of psychological distress were being relatively younger, single/divorced/widowed/separated, a current smoker, lower education, lower household annual income, lower alcohol intake, lower BMI, low physical activity levels and a self-reported history of chronic disease. The interaction between combined fruit and vegetable consumption and sex approached significance (p=0.08). When analyses were stratified by sex (table 3), the association between fruit and vegetable consumption, considered separately or combined, and the incidence of psychological distress was stronger in women and significant for all consumption tertiles except for the highest fruit (p=0.06), vegetable (p=0.17), and combined fruit and vegetable tertiles (p=0.09) in the fully adjusted models. There was no significant association between consumption of fruit and vegetables and the incidence of psychological distress in men.

    View this table:
    Table 4

    Unadjusted and adjusted ORs for the incidence of high-to-very high levels of psychological distress (K10*≥22) by baseline fruit and vegetable consumption (n=54 345†)

    Discussion

    In this large cohort of middle-aged and older Australian adults, consumption of fruit and vegetables was significantly associated with the prevalence of psychological distress even after accounting for sociodemographic characteristics and other lifestyle risk factors. The longitudinal associations with psychological distress were less consistent. The association between fruit and vegetable intake and the incidence of psychological distress was significant after accounting for age and sex. After adjustment for all possible confounders, while this association remained mostly significant at medium levels of intake, it did not remain significant at the highest levels of intake. When considered separately in each sex, the association of fruit and vegetable consumption with either the prevalence or incidence of psychological distress was stronger in women, with no clear associations with the incidence of psychological distress in men.

    Findings in this study are generally in agreement with those from a recent meta-analysis, based on seven cross-sectional and four cohort studies, which has found separate fruit and vegetable consumption to be inversely associated with the risk of depression.11 Although findings from individual cross-sectional and prospective studies were mixed, in subgroup analysis by study design, the meta-analysis showed significant associations in cross-sectional and prospective studies for fruit intake, and in prospective studies only for vegetable intake. In relation to combined fruit and vegetable consumption, several large cross-sectional studies have also demonstrated significant inverse associations with psychological well-being, even after accounting for multiple covariates.12–14 A positive association between combined fruit and vegetable consumption and well-being, assessed using seven different measures of mental health, was shown in three separate data sets, which together involved 80 000 randomly selected British adults.12 In a repeated cross-sectional study of 296 121 Canadians with five waves of a national, population-based survey, lower odds of depression and psychological distress were consistently associated with greater combined fruit and vegetable consumption.13 Our cross-sectional findings are also in line with those from a recent population-based Swiss survey of 20 220 individuals, which found that daily recommended intake of five servings of fruit and vegetables was associated with a lower likelihood of high and moderate psychological distress.14

    Our longitudinal findings add to the limited evidence base for an association between fruit and vegetable consumption and the incidence of psychological distress. Although longitudinal associations with psychological distress did not remain significant at higher levels of fruit and vegetable intake, the direction of these associations was in agreement with findings from previous studies. Among the few prospective studies which have examined the relationship between fruit and vegetable intake and the incidence of depression, mostly in similar-aged samples,15–17 ,28 all but one study28 have shown significant protective effects of fruit15 ,17 or both fruit and vegetables.16 A recent study involving a nationally representative sample of 12 385 Australian adults surveyed over several years reported that combined fruit and vegetable consumption was predictive of increased happiness, life satisfaction and well-being, with improvements observed within 2 years.29 In the case of our study, the longitudinal association between fruit and vegetable consumption and psychological distress was attenuated the most between the age-adjusted and sex-adjusted model and the fully adjusted model, suggesting confounding. This may indicate that those who consume healthy amounts of fruit and vegetables are more likely to have favourable socioeconomic status and other lifestyle risk factors (eg, physical activity), which together contributed to lower psychological distress.

    This study is among the first to report associations between fruit and vegetable consumption and psychological well-being separately for men and women. Sex was a significant effect modifier of the association between fruit and vegetable consumption and psychological distress. We found that fruit and vegetables were more protective for women than men, suggesting that women may be more responsive to the effects of fruit and vegetables. It is possible that there may be a true physiological difference between men and women, although a mechanism that could explain this difference remains unclear, or perhaps women more accurately report consumption of fruit and vegetables than men. However, these preliminary findings need to be confirmed by additional studies.

    Future investigations should also explore the possibility of a threshold between medium and higher consumption levels. In our study, fruit and vegetable consumption at the highest levels was not protective against psychological distress in fully adjusted models, suggesting a potential threshold effect. This was also evident in the fully adjusted models in the cross-sectional analysis in men, and the longitudinal analysis in women. The reason for this observation is unknown. It is possible that consuming more fruits and vegetables beyond the potential threshold is no longer beneficial. However, the observed pattern of association could also be a result of residual confounding. For example, participants consuming higher amounts of fruit and vegetables may also have been consuming larger quantities of other foods which could lead to psychological distress. However, despite adjusting for BMI in our analyses, this study did not measure other potential dietary confounders. The study's findings also did not change when adjusting for BMI as a continuous variable rather than a categorical variable. Participants with very high fruit and vegetable consumption may have other unmeasured characteristics that could have offset the beneficial effects of fruit and vegetable consumption. Finally, it is important to acknowledge that fruit and vegetable consumption was based on a one-time measure only, which could not take into account long-term consumption patterns. However, as compared with baseline, we found a similar pattern of consumption at follow-up (93% of participants remained in the same consumption categories between baseline and follow-up). Some of these limitations should be addressed in future studies.

    Although these remain to be elucidated, several mechanisms may underlie the relationship between high fruit and vegetable consumption and greater psychological well-being.30 Fruit and vegetables are rich in micronutrients and phytochemicals that may help reduce oxidative stress and inflammation, processes that can have detrimental effects on mental health. For example, antioxidants such as vitamins C, E and polyphenols may help reduce oxidative stress while the mineral magnesium has been associated with lower levels of C reactive protein, a marker of low-grade inflammation.30 Deficiencies in B vitamins such as folic acid (vitamin B9) have been associated with depression.31 Low levels of these vitamins can cause high homocysteine levels which in turn can impair methylation processes involved in the synthesis and metabolism of neurotransmitters that may affect mood.32

    Strengths and limitations

    This study had several strengths including a large sample size, a prospective design and the inclusion of multiple sociodemographic and lifestyle-related covariates and the use of the well-validated K10 to assess psychological distress. High K10 scores are strongly correlated with CIDI diagnoses of anxiety and depression.24 Several study limitations should be noted. The follow-up period may have been too short to observe the full extent of long-term associations between fruit and vegetable intake and psychological distress. Although the assessment of fruit and vegetable consumption was based on short validated questions, this assessment method may be prone to reporting bias. In addition, the assessment of dietary intake was not detailed and limited to a few questions only. There may be residual confounding from unmeasured dietary confounders including total energy intake and other potential confounders such as illicit drug use, a history of mental illness and unmeasured cardiometabolic components, despite adjustment for multiple covariates. Although data were available for fish consumption, another potential dietary confounder, this variable was not included as a covariate due to the lack of variance observed (‘yes/no’ question for ever consumption of fish only) and adjusting for fish consumption in our analyses also did not change our results. Further, the possibility of reverse causation (ie, that depression leads to poor diet including inadequate fruit and vegetable consumption) could not be eliminated, but was reduced by excluding participants being treated for depression/anxiety, taking antidepressant medication or who reported high-to-very levels of psychological distress at baseline from the longitudinal analyses. Several prospective cohort studies have not found evidence for reverse causation, with diet quality related to subsequent mental health but baseline mental health not associated with subsequent diet quality.15 ,17 ,21 However, a recent nationally representative longitudinal study of Canadians, which explicitly tested reverse causation, showed that the association between fruit and vegetable consumption, other health behaviours and depressive symptoms are complex and bi-directional and warrants further investigation.33

    Conclusions

    Fruit and vegetable consumption may help reduce the prevalence of psychological distress among middle-aged and older adults. However, the association between fruit and vegetable consumption and the incidence of psychological distress requires further investigation and possibly, a longer follow-up time. Fruit and vegetable consumption may help reduce psychological distress among middle-aged and older females in a cross-sectional context, but not potentially at the highest levels of intake in females over time. Consumption at medium levels of intake may help lower psychological distress in men in a cross-sectional context; however, longitudinal associations remain unclear. Although findings from this study lend support to existing public health guidelines which encourage fruit and vegetable consumption as part of a healthy diet and add evidence to support the benefits of fruit and vegetables for mental health, further research is clearly needed.

    Acknowledgments

    This research was completed using data collected through the 45 and Up Study (http://www.saxinstitute.org.au). The 45 and Up Study is managed by the Sax Institute in collaboration with major partner Cancer Council NSW; and partners: the National Heart Foundation of Australia (NSW Division); NSW Ministry of Health; NSW Government Family and Community Services—Ageing, Carers and the Disability Council NSW; and the Australian Red Cross Blood Service. The authors thank the many thousands of people participating in the 45 and Up Study and the SEEF Study. The SEEF research was funded by the National Health and Medical Research Council (NHMRC) Strategic Award for Preventive Healthcare and Strengthening Australia's Social Economic Fabric (the SEEF Project; ID: 402810).

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    Footnotes

    • Contributors BN, DD and SM participated in the design of the study. BN carried out the statistical analyses. BN, DD and SM helped draft the manuscript. All authors helped with the interpretation of the data and revised the manuscript critically for important intellectual content. All authors read and approved the manuscript.

    • Funding This research was funded from a Development Award from the Cardiovascular Research Network of NSW. BN was supported by an Australian Postgraduate Award and a University of Sydney Merit Award. DD was funded by an Early Career Fellowship from the NHMRC of Australia (reference number 1072223).

    • Competing interests None declared.

    • Ethics approval The 45 and Up Study was granted ethical approval by the University of NSW Human Research Ethics Committee (reference HREC 05035/HREC 10186) and the SEEF Study by the University of Sydney Human Research Ethics Committee (reference 10-2009/12187).

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement No additional data are available.

    Linked Articles

    • Miscellaneous
      Correction
      Antonia Johnston
      BMJ Open 2017; 7 - Published Online First: 07 Apr 2017. doi: 10.1136/bmjopen-2016-014201corr1