Objectives The aim of this systematic review of randomised controlled trials (RCTs), and quasi-experimental and retrospective studies is to investigate the effects of pulmonary rehabilitation (PR) in patients with advanced chronic disease on the waiting list for lung transplantation.
Setting PR performed for inpatient or outpatient lung transplant candidates.
Intervention PR programme including aerobic exercise training and/or resistance exercise training.
Primary and secondary outcomes Quality of life and exercise capacity (primary outcomes). Survival rate after transplant surgery; pulmonary function; respiratory muscle strength; psychological aspects; upper and lower extremity muscle strength and adverse effects (secondary outcomes). Two review authors independently selected the studies, assessed study quality and extracted data. Studies in any language were included.
Results This was a systematic review and studies were searched on the Cochrane Library, MEDLINE, EMBASE, CINAHL and PEDro. Experimental and retrospective studies evaluating the effects of PR in candidates for lung transplantation (>18 years old) with any lung diseases were included. 2 RCTs, and two quasi-experimental and two retrospectives studies, involving 1305 participants were included in the review. 5 studies included an enhancement reported in quality of life using the Short Form 36 questionnaire and showed improvements in some domains. All studies included exercise capacity evaluated through 6 min walk test and in five of them, there were improvements in this outcome after PR. Owing to the different characteristics of the studies, it was not possible to perform a meta-analysis.
Conclusions Studies included in this review showed that PR is an effective treatment option for patients on the waiting list for lung transplantation and can improve quality of life and exercise capacity in those patients. Although individual studies reported positive effects of PR, this review shows that there is a need for more studies of a high methodological quality addressing PR effects in lung transplant candidates.
Trial registration number PROSPERO CDR42015025110.
- Lung transplantation
- Lung diseases
- Physical therapy
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Strengths and limitations of this study
This was the first systematic review focused on pulmonary rehabilitation (PR) before lung transplantation.
The results of this review show that the literature does not adequately address the effects of PR in patients on a waiting list for lung transplantation. It is known that PR has been considered standard care for patients with pulmonary chronic diseases who might be included on a transplant list.
Only a few studies could be included in this systematic review, which shows a need for more studies designed to evaluate the objectives of the study.
A meta-analysis could not be performed due to the insufficient number of studies included.
Patients with different pulmonary conditions such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, idiopathic pulmonary fibrosis and pulmonary arterial hypertension can progress to advanced lung disease that causes a pronounced impact on life. Usually patients with advanced lung disease have a higher degree of ventilatory limitation and disability, and a greater risk of complications.1 They also have reduced exercise tolerance, which is associated with dyspnoea and fatigue.2 ,3 Lung transplantation is a well-accepted therapy designated for a range of severe lung conditions, and evidence supports its success in improving survival and quality of life. It is known that the number of organ donors is much lower than the number of patients with severe lung conditions. Therefore, a patient selected to undergo transplantation must be a candidate with expectations for a good long-term outcome.4
Access to lung transplantation, a complex procedure, is becoming a more reasonable option for patients with advanced lung disease, especially those patients with chronic respiratory failure, cardiovascular risk factors, and muscular and nutritional conditions, factors that can influence the prognosis for a successful lung transplantation.5 Therefore, pulmonary rehabilitation (PR) is an important process that focuses on avoiding comorbidities and complications.5
Most PR programmes are in accordance with the American College of Sports Medicine (ACSM), which recommends that patients with chronic diseases participate in aerobic exercise, resistance training, flexibility training and muscular fitness activities. In general, PR exercises follow the principles of exercise prescription guidelines from the ACMS, which is a methodology based on frequency, intensity, time and type of activity. Usually there is no consensus on the optimal exercise intensity for patients with chronic respiratory disease.6 However, intensity is based on a rated perceived exertion or 60% to 80% of peak work rate if results from an exercise test are available.6
The PR programme must be individualised and the modality and intensity of training must be selected individually for each patient. The duration of the training can vary from 6 weeks to 6 months and it is conducted by multidisciplinary teams.7 In 2013, the American Thoracic Society and the European Respiratory Society defined PR as “an evidence-based, multidisciplinary, and comprehensive intervention for symptomatic patients with chronic respiratory disease that present decreased activities of daily living. PR aims to reduce symptoms, optimise functional status, increase participation, and reduce healthcare costs making the manifestations of the disease stable or reversible”.2
Many rehabilitation centres incite the enrolment of patients with advanced lung disease in PR before lung transplantation. The role of PR in preoperative patients is essential to restore them to independent functioning, relieve symptoms, decrease disability and increase quality of life by increasing their participation in social and physical activities.8 It has been proven that exercise capacity (6 min walking distance) and resting carbon dioxide in arterial blood values are directly related to the rate of success in lung transplantation.8 Szelkely et al9 evidenced that those parameters can predict hospital stay after surgery and mortality and PR can decrease intensive care unit days, mechanical ventilation days and chest tube days.9 Costache et al10 showed that improvements in post-transplant survival might have been originated from pretransplant PR along with other factors that enhanced during surgery better immunosuppressive regimens and antibiotic protocols and decreased blood needs. PR plays an important role for the maintenance of exercise tolerance and physical functioning before and especially after lung transplantation as common extrapulmonary manifestations could be persistent in this period.11 In a systematic review Wickerson et al12 demonstrated that exercise should be included in the regular management of patients for lung transplant before and after transplantation. Although there is an absence of specific PR protocol for patients for lung transplant it seems that it could enhance positive effects on maximal and functional exercise capacity, quality of life and skeletal muscle function.12
As mentioned previously, patients for lung transplant usually have a very challenging and advanced disease and face a greater limitation in activity and restriction in participation in PR programme. Nevertheless, the clinical benefits of PR for patients with COPD and other forms of advanced lung disease make the engagement in a PR programme required for patients for lung transplant in the preoperative time period.1 It is important to synthesise the evidence obtained from a PR programme in order to improve this service in rehabilitation centres considering its benefits to patients with advanced lung disease and improving their adherence.
To gather evidence on the effects of PR in people with advanced chronic disease who are on the waiting list for lung transplantation.
Protocol and registration
The protocol for this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO CDR42015025110) on 7 August 2015 before titles were investigated and studies selected for search results. This review is reported in accordance with PRISMA guidelines.13
Types of studies
Experimental studies and retrospective studies were included.
Types of participants
Candidates for lung transplantation (>18 years old) with any lung diseases.
Types of interventions
We included studies evaluating the effects of PR before lung transplantation.
Types of outcome measures
The primary outcomes this review proposed to look for were: quality of life measured by any respiratory disease-specific or generic instrument and exercise capacity measured by the usual tests applied in clinical settings such as the 6 min walk test (6MWT), incremental shuttle walk test, as well as other maximal or submaximal cardiopulmonary tests.
The secondary outcomes were: survival rate after transplant surgery; pulmonary function that could be measured by spirometry, body plethysmography or diffusion capacity for carbon monoxide; respiratory muscle strength measured by maximal inspiratory and expiratory pressure; psychological aspects assessed using questionnaires; upper and lower extremity muscle strength measured by one maximal repetition or other manual or non-manual muscle test, and adverse effects.
We included articles reported in any language.
The literature search strategies were developed using medical subject headings (MeSH) related to PR and lung transplant candidates.
Studies were identified from searches of the following databases: Cochrane Central Register of Controlled Trials (CENTRAL), latest issue (the Cochrane Library); MEDLINE (Ovid) 1946 to date; EMBASE (Ovid) 1974 to date; CINAHL Plus (Ebsco) 1937 to date, and trials registries (ClinicalTrials.gov and the WHO trials portal).
The proposed MEDLINE strategy is listed in online supplementary appendix 1. This strategy was adapted for use in the other databases.
All databases were searched from their inception to the present, and there was no restriction on publication language.
The reference lists of all primary studies were checked and review articles were checked for additional references.
Two review authors (MH and GC) independently screened the titles and abstracts of all potential studies identified in the search. The studies were coded as ‘retrieve’ (eligible or potentially eligible/unclear) or ‘do not retrieve’.
We retrieved the full-text study report/publication, and the two review authors (MH and GC) independently screened the full text, identified studies eligible for inclusion and identified and recorded the reasons for exclusion of ineligible studies. Disagreement was resolved through discussion, or, if required, a third review author was consulted (VFP).
A data collection form was used for the study characteristics and outcome data was pilot-tested on at least one study in the review. Two review authors (MH and GC) extracted the study characteristics from the included studies. The following study characteristics were extracted:
Methods: study design, total duration of study, details of any ‘run in’ period, number of study centres and location, study setting, withdrawals and date of study.
Participants: N, mean age, age range, gender, severity of condition, diagnostic criteria, baseline lung function, smoking history, inclusion criteria and exclusion criteria.
Interventions: intervention, comparison, concomitant medications and excluded medications.
Outcomes: primary and secondary outcomes specified and collected, and time periods reported.
Notes: funding for trial, and notable conflicts of interest of trial authors.
Two review authors (MH and GC) independently extracted outcome data from the included studies. The ‘Characteristics of included studies’ table notes whether outcome data were reported in a usable way. Disagreements were resolved by consensus or by involving a third review author (VFP).
Risk of bias individual studies
Two review authors (GC and GAR-S) independently assessed risk of bias for each study using the criteria outlined in the Cochrane Handbook for Systematic Reviews of Interventions.14 Any disagreements were resolved by discussion or by involving another author (RRB). The risk of bias was assessed according to the following domains.
Random sequence generation.
Blinding of participants and personnel.
Blinding of outcome assessment.
Incomplete outcome data.
Selective outcome reporting.
Each potential source of bias was graded as high, low or unclear, and a quote was provided from the study report together with a justification for our judgement in the ‘Risk of bias’ table. The risk of bias judgements across different studies for each of the domains was summarised.
The review was conducted according to the Cochrane Collaboration tool for assessing the risk of bias (table 8.5.a in the Cochrane Handbook for Systematic Reviews of Interventions).14
Dealing with missing data
We contacted investigators in order to verify key study characteristics and obtain missing numerical outcome data where possible (eg, when a study was identified as an abstract only).
As a meta-analysis could not be undertaken, we have provided a narrative synthesis of the available data.
Results of the search
In November 2015, we identified a total of 1413 studies including duplicates. This total was composed of 165 hits from MEDLINE, 1172 from EMBASE, 60 from CENTRAL and 16 from CINAHL. We did not find any ongoing studies suitable for the review in clinicaltrials.gov or in the WHO ICTRP. After screening the titles and abstracts, we identified 13 studies as potentially relevant. We obtained the full text for those studies with ambiguous titles and abstracts so we could determine whether to include them from the review. Six studies met the inclusion criteria.15–20 See figure 1 for full details on the results of the search. No further studies were included in this review.
The studies varied in size from 9 to 811 participants. All participants in the studies included were older than 18 years of age. The patients were on lung transplant waiting lists in all the studies.
Intervention and control groups
In the Li et al15 study, data from candidates for lung transplant who received PR at a hospital consisting of stretching, aerobic exercises and resistance training three times per week for 1.5 to 2 hours for a mean of 47±59 sessions was analysed. In the Florian et al16 study, all participants in the intervention group underwent training for 36 sessions for 90 min per session. In the Jastrzebski et al17 study, patients performed Nordic walking exercise training with ski poles at ∼75% of their maximum heart rate for 12 weeks (two cycles of 2-week hospital-based supervised rehabilitation and 4-week home-based rehabilitation). In the Gloeckl et al18 study, patients followed a multidisciplinary 3-week inpatient rehabilitation programme that included exercise units for 5–6 days/week, but during the second and third week, exercise training was split into two sessions per day. The total amount of exercise time per session increased from 10 to 30 min for continuous training and from 12 to 36 min for interval training, yielding an isocaloric total work in both groups. In the Kenn et al19 study, data were evaluated from 811 patients referred for lung transplantation who were enrolled in PR 5–6 days per week for supervised sessions of endurance training of 10–20 min at 60% of peak work rate and graduated from a cycle test plus 30–45 min of strength exercises. In the Manzetti et al20 study, sessions were offered three times a week for 6 weeks. The education plus exercise group attended an exercise programme twice a week for 6 weeks with 30 min of aerobic training, and the participants in the education group were not recommended for exercise.
The six studies included15–20 evaluated exercise capacity through the 6MWT. Five studies15–19 evaluated health-related quality of life (HRQL) through the Short Form 36 questionnaire (SF-36 questionnaire). The study by Li et al15 also evaluated HRQL using the Saint George Respiratory Questionnaire (SGRQ), the Standard Gamble, the Visual Analogue Scale and the EuroQol five dimensions questionnaire (EQ-5D). Two studies (refs. 17 ,18) assessed lung function measured with either a MasterScreen Body plethysmograph or spirometry. The study by Manzetti et al20 also evaluated exercise tolerance through cardiopulmonary exercise testing and quality of life with different scales (Quality of Well-being scale (QWB), Quality of Life Index (QLI) and Symptom Frequency/Symptom Distress scale (SFSD)) and the Li et al15 study assessed exercise tolerance by measuring training volumes and calorie expenditure from the start of PR until the transplant.
Risk of bias
Assessment of the risk of bias was performed in both RCTs. Full details for the risk of bias judgements can be found in figure 2.
One study reported adequate sequence generation and allocation concealment and was judged to have a low risk of bias.18 One study was judged to have a high risk of bias once the randomisation described was determined to be inappropriate.20
The Gloeckl et al18 study described the blinding of participants and personnel as not possible and was judged to have a high risk of bias because the outcomes could have been influenced by this shortcoming. Another study20 did not describe blinding of participants and personnel, so it was judged to have an unclear risk of bias.
Blinding of outcome assessors was described in Gloeckl et al,18 which was judged to have low risk of bias. The Manzetti et al20 study did not provide sufficient data to permit judgement, so it was judged to have an unclear risk of bias.
Incomplete outcome data
The Gloeckl et al18 study informed the missing outcome data as numbers balanced across the intervention groups, with similar reasons allowed for missing data across groups and it performed an intention-to-treat analysis. The Manzetti et al20 study was judged to have a high risk of bias because it did not assess whether the groups were similar at the baseline, although it described the reasons for drop-outs.
The Gloeckl et al18 study was registered on clinicaltrials.gov, and all of the prespecified primary and secondary outcomes were reported in a prespecified way. The Manzetti et al20 study failed to include results for a key outcome that should have been reported.
Other potential sources of bias
We identified other potential sources of bias in two studies. In the Gloeckl et al18 study some patients in the continuous training group also presented interval-training characteristics due to the high number of unintended breaks. In the Manzetti et al20 study the sample size was small and the participants in the education group had diagnoses that resulted in physiological limitations that may have been more likely to respond to interventions included in an exercise programme and this study also showed inappropriate statistical analysis.
Effects of interventions
Primary outcomes: quality of life
Five of the six studies included a reported enhancement in quality of life using the SF-36 questionnaire showing improvements in some domains over time. In the Li et al15 study, the mental health component also significantly decreased after PR (47±11 to 45±12, p<0.05). In this study, all components of the SGRQ showed significant decline after the PR programme (65±14 to 69±11, p<0.05) and in the EQ-5D scores (0.55±0.24 to 0.47±0.27, p<0.05), revealing an improvement in health-related quality of life after completing the PR. In the Florian et al16 study, participants improved in physical functioning (p=0.001), role-physical (p=0.045); vitality (p<0.001); social functioning (p=0.001); and mental health (p=0.001). In the Jastrzebski et al17 study quality of life showed improvement through an increase in the physical cumulative score from the SF-36 (27.2±8.2 to 29.9±9.1, p<0.05) after 6 weeks of PR. In the Gloeckl et al18 study although all sum scores of the SF-36 improved, only the physical health summary score in the control group (4.3±6.9 points) and the mental health summary score (9.7±13.0 points) in the intervention group increased significantly. In the Kenn et al study,19 the retrospective analysis of data from the SF-36 showed improvements in the physical health summary after the PR programme (mean δ: 1.9, SD δ: 8.5, p<0.001) and in the mental component summary (mean δ: 8.7, SD δ: 13.5, p<0.001). The Manzetti et al20 study used three different questionnaires: results showed that the QWB scores improved significantly over time (p=0.005), with both groups demonstrating higher scores at the completion of the study. However, there were no significant differences between the groups or interaction. For the QLI and SFSD scores, there were no significant differences between the groups, over time or interaction.
Primary outcomes: exercise capacity
All studies included in this review evaluated exercise capacity through the 6MWT. The study by Li et al15 showed that patients walked an average of 320±119 m in the beginning and 314±116 m in the final 6MWT prior to transplantation, presenting an average of 15 m less after an average of 47 sessions (p=0.002). In the Florian et al study,16 after completion of the programme, there was a mean increase of 72 m in the 6MWT (p=0.001), whereas a significant decrease in perceived dyspnoea was described (p=0.001).16 A significant increase in the 6MWT distance was found in the study by Jastrzebski et al,17 from 310.2±130.2 to 361.9±131.5 m, which means an average increase of 51.6 m (p<0.005). In the Gloeckl et al study,18 the exercise programme was effective in both groups (a significant increase in the 6MWT of 35±28 m for the interval group and 36±42 m for the continuous group, p<0.05). Similar to the Jastrzebski et al17 study, a significant increase in the 6MWT distance was found in the study by Kenn et al19 with a mean different pre-PR to post-PR of 55.9±58.5 m (p<0.001). In the Manzetti et al20 study, the 6MWT improved significantly over time (p<0.03). However, no significant differences between groups were found. Manzetti et al20 evaluated exercise tolerance through cardiopulmonary exercise in nine participants and showed that there were no significant differences in workload between the groups, over time or in interaction.
Secondary outcomes: pulmonary function
Jastrzebski et al17 assessed lung function by spirometry and showed a significant increase in the mean value of forced vital capacity after 12 weeks of PR (44% to 53% of predicted values; p<0.05). Gloeckl et al18 assessed lung function measured by plethysmograph in 60 participants and showed that at discharge, none of the lung function parameters were significantly different from baseline values.
Secondary outcomes: adverse effects
The study by Jastrzebski et al17 evaluated the effects of PR on the dyspnoea ratings using the Medical Research Council (MRC) questionnaire, the baseline dyspnoea index and the oxygen cost diagram and although there were improvements in those measurements, they did not achieve statistical significance.
Secondary outcomes: survival rate after transplant surgery; respiratory muscle strength; psychological aspects and upper and lower extremity muscle strength.
None of the studies that were included specifically evaluated any of these outcomes.
Summary of main results
This systematic review assessed the effects of PR in patients with lung disease on a waiting list for lung transplantation. Six studies were included with a total of 1305 patients who had the following conditions: COPD, idiopathic pulmonary fibrosis, pulmonary emphysema, interstitial idiopathic pneumonia, non-specific interstitial pneumonia or other types of advanced lung disease. Although these studies met the inclusion criteria, they differed significantly in terms of intervention characteristics and methods. Since the included studies employed different interventions by using different methodologies, a meta-analysis for lung function was not possible due to the high heterogeneity.
None of the articles addressed the effects of PR on the survival rate after transplant surgery or on the respiratory muscle strength. Overall, PR was applied as physical exercise, which in only one study was divided into two groups: continuous training or interval training, and its effects were observed in different outcomes.
Overall completeness and applicability of the evidence
Two randomised controlled trials, two quasi-experimental studies and two retrospective studies were included and although they had a different design, all the studies defined PR as a therapeutic option for patients for lung transplant that was capable of reducing dyspnoea, increasing exercise capacity and improving quality of life.
All studies included patients with similar age ranges on a waiting list for lung transplantation; however, there was heterogeneity in the types of disease included in each study. Gloeckl et al18 included only patients with COPD stage IV in accordance with the GOLD assessment,21 while Florian et al,16 Manzetti et al,20 Jastrzebski et al,17 Kenn et al19 and Li et al15 included any patient on a waiting list for lung transplantation regardless of the health condition. While some could argue that this heterogeneity renders the results of this review less significant, it is the positive results from PR raised in the six studies that suggest how important this therapy is to this population irrespective of the underlying disease.
With regard to exercise capacity, four of the six studies that were included reported an increase in the 6MWT after participation in PR.16–18 ,20 The 6MWT evaluates exercise capacity and it is an important tool to identify benefits derived from different therapeutic interventions such as PR.22 It is known that there is a minimal clinically important difference (MCID) in the 6MWT that ranges from 25 to 35 m for lung diseases, which is related to an increase in survival.22–24 The four studies mentioned above16–18 ,20 showed an improvement in the MCID reinforcing the importance of PR for patients with lung disease.
The literature indicates that a significant relationship exists between the baseline 6MWT for patients on the waiting list for a lung transplant and survival, and that the results from the 6MWT—as a continuous variable—are related to patient mortality.25 ,26 A reduction of more than 50% in mortality for every 500-feet increment in the baseline 6MWT was indicated by Martinu et al25 and a cut-off of 207 m in the test to predict survival was shown by Lederer et al.27 Although there is a strong correlation between the 6MWT and the rate of post-transplant survival, Castleberry et al26 showed a low accuracy in dichotomisation in predicting 1-year mortality. Thus, the ability of a single value to predict mortality is limited and it should be used carefully.
Quality of life was assessed by five studies using the SF-36 questionnaire. Florian et al15 and Kenn et al19 found an increase in the domains of physical functioning and mental health, while Gloeckl et al18 only found an increase in the mental health component and Jastrzebski et al17 found an increase only in the physical functioning component. Li et al15 found a decrease in the mental health component of the SF-36 questionnaire, but reported a good result after the application of the SGRQ with a significant decrease in the total score and in all domains. Manzetti et al20 also evaluated the patient's quality of life using a QWB that showed a significant improvement after PR.
Health-related quality of life is an important component to determine the impact of chronic diseases in patients' perceptions about their own health.28 Gilbert and Smith28 showed that PR is recommended for patients with advanced lung disease because of increases in quality of life scores and decreases in sensations of dyspnoea. Similar results were found in a recent systematic review of patients with COPD that showed significant improvements in quality of life after PR.29 However, the same study showed that after a follow-up, no clinically relevant difference was found in this outcome.29 Furthermore, it was demonstrated in a systematic review that there is an association between specific comorbidity in COPD and worse quality of life.30
Only two of the six studies that were included evaluated some of the secondary outcomes considered in this review, but none of them evaluated upper and lower extremity muscle strength. Nonetheless, rehabilitation has been proven to also improve limb muscle function in patients with lung disease such as COPD.31 A statement from American Thoracic Society (ATS) and European Respiratory Society (ERS) highlighted that quadriceps muscle strength, endurance and fatigability improved significantly after exercise training in patients with COPD.31 Moreover, a relationship between quadriceps muscle function and exercise capacity has been found in patients with COPD and in patients with interstitial lung disease (ILD) that presented weakness in the knee extensors.32 Considering the importance of skeletal muscle dysfunction, Liao et al33 in a systematic review, proved that resistance training significantly improved knee extension strength and that this could be related to better exercise capacity and reduced dyspnoea.
Quality of the evidence
This review is limited due to a lack of studies in the literature addressing the topic that was chosen. In addition, the studies that were included had different intervention protocols and different designs, which made comparisons between them more difficult.
From the two RCTs included in the review, only one described the random sequence generation method and allocation concealment so it was classified as having a low risk of bias. According to Savović et al,34 inadequate reporting of trial methods can severely compromise the assessment of study quality and the risk of bias in the study results. Furthermore, ineffectively reported randomisation has been associated with bias in estimating the effectiveness of interventions.35 The study by Gloeckl et al18 reported that researchers were blinded regarding the allocation of patients. In a randomised controlled trial that involves exercises, it is not possible for the participants and the personnel to be blinded to the intervention and the lack of double blinding or its unclearness can be associated with intervention effects overestimation.
Potential biases in the review process
A systematic process for the inclusion of studies and prespecified criteria for the methods were implemented in order to minimise the risk of bias in this review.
Incomplete outcome data and selective reporting were considered potential sources of bias in this review. These issues had limited analytical value once the data from the two RCTs could not be entered into a meta-analysis. Additionally, subgroup and sensitivity analyses were not possible due to the insufficient data.
Subgroup analysis could have showed possible differences in disease pathophysiology, age groups and duration of PR. Furthermore, sensitivity analysis could have identified the influence of trial quality and trial size on the results, therefore revealing a source of the substantial heterogeneity found among studies.
Agreements with other studies
PR has been defined as a component of the management of pulmonary diseases according to the ATS and the ERS.2 The studies included in this review are in agreement with an extensive number of studies on the benefits of PR in other lung conditions.2 ,7 Nonetheless, to the best of our knowledge this is the first review to assess the effectiveness of PR in patients on a waiting list for lung transplantation.
In 2013 the ATS and the ERS incorporated the concepts of PR for patients with different chronic respiratory diseases other than COPD and the PR scope to reduce symptoms, increase participation, optimise functional status and reduce healthcare costs.2
Dowman et al36 studied PR in ILD and found its benefits in improving functional exercise capacity, dyspnoea and quality of life in these patients. Troosters et al37 on the other hand, studied PR in patients with COPD and, as Dowman et al,36 found benefits in functional capacity, health-related quality of life besides improvement in activity, daily function and restoration of independent function. The study by Mereles et al38 shows the same benefits of PR in patients with pulmonary hypertension. Regarding patients with severe chronic respiratory disease preparing for lung transplantation or lung volume reduction surgery, Rochester et al.1 present in a review study the function of PR in the care of these patients. This review supports that although it is not known whether PR increases survival to surgery, increases patient tolerance for surgery or reduces postoperative complications, it is clear that it improves exercise tolerance, health status, dyspnoea and quality of life.1
Although there are RCTs and other studies regarding PR in different lung conditions, pretransplantation PR reports have been few and uncontrolled, and RCTs are lacking and they were discussed in this review.
Although this review could not perform a meta-analysis, the studies that were included indicate that PR can improve exercise capacity and quality of life over time, regardless of the type of exercise that is conducted and the disease background of the patient. The most important topic arising from the studies assessed in this review is that PR can be a beneficial and efficient treatment for patients with advanced lung disease on the waiting list for lung transplantation.
Well-conducted studies are needed to assess the benefits of PR in lung transplant candidates. In addition, more attention needs to be paid to good reporting and high-quality study design, including items such as adequate random sequence generation and allocation concealment, blinding and determination of trial sample size before a study is initiated.
Contributors MH and GC were the main systematic reviewers and worked across all stages of the review from inception to completed draft. GAR-S is the statistical expert and provided advice on data analysis and commented on the final document content. RRB provided advice on data analysis and commented on the final document content. VFP provided advice throughout the project, and was involved in screening, selection and commenting on the analysis and the final document content.
Funding This project was partially supported by Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais and by Conselho Nacional de Desenvolvimento Científico e Tecnológico (grant numbers: 309494/2013-3 and 442973/2014-4), Brazil.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement No additional data are available.
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