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Weight for gestational age and metabolically healthy obesity in adults from the Haguenau cohort
  1. Joane Matta1,
  2. Claire Carette2,
  3. Claire Levy Marchal3,
  4. Julien Bertrand4,5,
  5. Mélanie Pétéra4,5,
  6. Marie Zins1,6,
  7. Estelle Pujos-Guillot4,5,
  8. Blandine Comte4,5,
  9. Sébastien Czernichow1,2,6
  1. 1INSERM, UMS 011, Villejuif, France
  2. 2Nutrition Department, Hôpital Européen Georges-Pompidou, Paris, France
  3. 3INSERM CIE 05 - Unité d'épidémiologie clinique, Hôpital Robert Debré, Paris, France
  4. 4INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 CLERMONT-FERRAND, France
  5. 5Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 CLERMONT-FERRAND, France
  6. 6Paris Descartes University, Paris, France
  1. Correspondence to Professor Sébastien Czernichow; sebastien.czernichow{at}


Background An obesity subphenotype, named ‘metabolically healthy obese’ (MHO) has been recently defined to characterise a subgroup of obese individuals with less risk for cardiometabolic abnormalities. To date no data are available on participants born with small weight for gestational age (SGA) and the risk of metabolically unhealthy obesity (MUHO).

Objective Assess the risk of MUHO in SGA versus appropriate for gestational age (AGA) adult participants.

Methods 129 young obese individuals (body mass index ≥30 kg/m²) from data of an 8-year follow-up Haguenau cohort (France), were identified out of 1308 participants and were divided into 2 groups: SGA (n=72) and AGA (n=57). Metabolic characteristics were analysed and compared using unpaired t-test. The HOMA-IR index was determined for the population and divided into quartiles. Obese participants within the first 3 quartiles were considered as MHO and those in the fourth quartile as MUHO. Relative risks (RRs) and 95% CI for being MUHO in SGA versus AGA participants were computed.

Results The SGA-obese group had a higher risk of MUHO versus the AGA-obese group: RR=1.27 (95% CI 1.10 to 1.6) independently of age and sex.

Conclusions In case of obesity, SGA might confer a higher risk of MUHO compared with AGA.


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