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Research methods
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Impact of including or excluding both-armed zero-event studies on using standard meta-analysis methods for rare event outcome: a simulation study

Authors

  • Ji Cheng Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Eleanor Pullenayegum Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada The Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • John K Marshall Department of Medicine, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Alfonso Iorio Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada Department of Medicine, McMaster University, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  • Lehana Thabane Department of Clinical Epidemiology & Biostatistics, McMaster University, Hamilton, Ontario, Canada St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Lehana Thabane; thabanl{at}mcmaster.ca
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Citation

Cheng J, Pullenayegum E, Marshall JK, et al
Impact of including or excluding both-armed zero-event studies on using standard meta-analysis methods for rare event outcome: a simulation study
BMJ Open 2016;6:e010983. doi: 10.1136/bmjopen-2015-010983

Publication history

  • Received January 12, 2016
  • Revised July 14, 2016
  • Accepted July 19, 2016
  • First published August 16, 2016.
Online issue publication 
October 25, 2017
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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/