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Anaesthesia
Protocol
Intrathecal drug delivery systems for the management of chronic non-cancer pain: protocol for a systematic review of economic evaluations
  1. Rui V Duarte1,
  2. Tosin Lambe2,
  3. Jon H Raphael3,4,
  4. Sam Eldabe5,
  5. Lazaros Andronis2
  1. 1Department of Public Health, Epidemiology and Biostatistics, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
  2. 2Health Economics Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK
  3. 3Faculty of Health, Birmingham City University, Birmingham, UK
  4. 4Department of Pain Management, Russells Hall Hospital, Dudley, UK
  5. 5Department of Pain and Anaesthesia, The James Cook University Hospital, Middlesbrough, UK
  1. Correspondence to Dr Rui V Duarte; r.duarte{at}bham.ac.uk

Abstract

Introduction Intrathecal drug delivery (ITDD) systems are an option for the management of patients with chronic non-cancer pain, cancer pain and spasticity. Concerns over their invasiveness and high initial costs have led National Health Service (NHS) England to decommission ITDD for patients with chronic non-cancer pain. However, the extent to which this decision is in line with existing economic evidence is unclear. To address this question, we will carry out a systematic review to identify and evaluate the existing evidence on the cost-effectiveness of ITDD for chronic non-cancer pain.

Methods and analysis A high-sensitivity search strategy will be employed in Cochrane Library, MEDLINE, EMBASE, Web of Science, NHS EED, DARE and HTA. Database searches will be complemented by additional searching techniques. Screening of the results will be performed by 2 reviewers independently using predetermined inclusion and exclusion criteria. Full and partial economic evaluations will be included. Data extraction will be carried out using a form created for the purposes of this review. Quality assessment of all included studies will be performed using recommended checklists.

Ethics and dissemination Ethical approval is not required as primary data will not be collected. Findings will be disseminated through peer-reviewed publications and conference presentations.

PROSPERO registration number CRD42016035266.

  • Chronic pain
  • Cost-effectiveness
  • Economic evaluations
  • Intrathecal drug delivery

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2016-012285

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