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Effectiveness of influenza vaccination for preventing influenza-related complications in people with asthma: a systematic review protocol
  1. Eleftheria Vasileiou1,
  2. Aziz Sheikh1,
  3. Chris Butler2,3,
  4. Beatrix von Wissmann4,
  5. Jim McMenamin4,
  6. Lewis Ritchie5,
  7. Lilly Tian6,
  8. Colin Simpson1
  1. 1Asthma UK Centre for Applied Research, Usher Institute of Population Health Sciences and Informatics, The University of Edinburgh, Teviot, Medical School, Edinburgh, UK
  2. 2Nuffield Department of Primary Care Health Sciences, Oxford University, New Radcliffe House, Radcliffe Observatory Quarter, Oxford, UK
  3. 3Cardiff University, Institute of Primary Care and Public Health, Cardiff, UK
  4. 4Health Protection Scotland, NHS National Services Scotland, Meridian Court, Glasgow, UK
  5. 5Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK
  6. 6The University of Edinburgh, Teviot, Medical School, Edinburgh, UK
  1. Correspondence to Eleftheria Vasileiou; E.Vasileiou{at}


Introduction Influenza vaccination is administered annually as a preventive measure against influenza infection and influenza-related complications in high-risk individuals, such as those with asthma. However, the effectiveness of influenza vaccination in people with asthma against influenza-related complications is still not well established.

Methods and analysis We will search the following databases: MEDLINE (Ovid), EMBASE (Ovid), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, Cochrane Database of Systematic Reviews (CDSR), Web of Science Core Collection, Science direct, WHO Library Information System (WHOLIS), Global Health Library and Chinese databases (CNKI, Wanfang and ChongQing VIP) from Jan 1970 to Jan 2016 for observational and experimental studies on effectiveness of influenza vaccine in people with asthma. The identification of studies will be complemented with the searching of the reference lists and citations, and contacting influenza vaccine manufacturers to identify unpublished or ongoing studies. Two reviewers will extract data and appraise the quality of each study independently. Separate meta-analyses will be undertaken for observational and experimental evidence using fixed-effect or random-effects models, as appropriate.

Ethics and dissemination Formal ethical approval is not required, as primary data will not be collected. The review will be disseminated in peer-reviewed publications and conference presentations.


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