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Effect of early goal-directed therapy on mortality in patients with severe sepsis or septic shock: a meta-analysis of randomised controlled trials
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  • Published on:
    Early Goal Directed Therapy (EGDT) for sepsis is dead and buried
    • Paul Marik, Chief, Pulmonary and Critical Care Medicine

    Three large, international, multicenter randomized trials have convincingly demonstrated that Early Goal Directed Therapy (EGDT) does not improve the outcome of patients with severe sepsis and septic shock. A meta-analysis by the ARISE, ProCESS and ProMISe investigators concluded that "EGDT is not superior to usual care for ED patients with septic shock but is associated with increased utilisation of ICU resources".[1] The...

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