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Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study
  1. Gang Liu1,
  2. Geng Zong1,
  3. Richard L Doty2,
  4. Qi Sun1,3
  1. 1Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA
  2. 2Smell and Taste Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  3. 3Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
  1. Correspondence to Dr Qi Sun; qisun{at}hsph.harvard.edu

Abstract

Objectives To estimate the prevalence of, and explore potential risk factors for, taste and smell dysfunction in the general population of the USA.

Design A cross-sectional study.

Setting A cross-sectional analysis of data collected in the National Health and Nutrition Examination Survey (NHANES 2013–2014).

Participants A total of 3519 men and women aged 40 years and older who participated in NHANES 2013–2014.

Main outcome measures Using the NHANES Pocket Smell Test, smell impairment was defined as failing to correctly identify 6 or more of the 8 odours. Taste impairment was defined as failing to correctly identify quinine or sodium chloride.

Results The estimated prevalence was 13.5% for smell impairment, 17.3% for taste impairment and 2.2% for taste and smell impairment. For smell, but not taste, prevalence estimates increased with age and were higher in men and ethnic minorities. In backward stepwise logistic regression, low educational attainment, low family income and a history of asthma or cancer were independently associated with a higher prevalence of smell impairment, whereas light-to-moderate alcohol consumption (1–3 drinks/day) was associated with a lower prevalence of this condition. After multivariate adjustment, being non-Hispanic Black Americans, consuming ≥4 drinks of alcohol per day and having a history of cardiovascular disease (CVD) were independently associated with a higher prevalence of taste impairment.

Conclusions Based on a nationally representative multistage probability survey among the US population aged 40 years and older, smell and taste dysfunction affected ∼20.5 million (13.5%) and 26.3 million (17.3%) individuals, respectively. Age, gender, ethnicity, educational attainment, family income, light-to-moderate alcohol consumption and history of asthma or cancer were significant risk factors for smell dysfunction, whereas only ethnicity, heavy alcohol consumption and CVD history were associated with a higher prevalence of taste dysfunction.

  • Taste Impairment
  • Smell Impairment
  • Prevalence
  • Risk factors

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Footnotes

  • Contributors QS was responsible for the study concept. GL, GZ and QS were responsible for analysis and interpretation of data. GL wrote the first draft of the manuscript. RLD contributed to results interpretation, statistical analysis and critical revision of the manuscript. All authors approved the finally version of the manuscript.

  • Funding QS was supported by a career development award, R00-HL098459, from the National Heart, Lung, and Blood Institute, and ES021372 and ES022981 from the National Institute of Environmental Health Sciences. GL was supported by the International Postdoctoral Exchange Fellowship Program 2015 by the Office of China Postdoctoral Council.

  • Competing interests RLD is the president and major shareholder of Sensonics International, the manufacturer of the NHANES Pocket Smell Test.

  • Patient consent Obtained.

  • Ethics approval Ethical committee at the National Center for Health Statistics.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement No additional data are available.

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