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Is famine exposure during developmental life in rural Bangladesh associated with a metabolic and epigenetic signature in young adulthood? A historical cohort study
  1. S Finer1,
  2. M S Iqbal2,,
  3. R Lowe1,,
  4. B W Ogunkolade1,,
  5. S Pervin2,
  6. C Mathews1,
  7. M Smart1,
  8. D S Alam2,*,
  9. G A Hitman1,*
  1. 1Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, London, UK
  2. 2Center for Control and Chronic disease' to Initiative for Non-Communicable Diseases (INCD), Health System and Population Studies Division, ICDDR,B, Dhaka, Bangladesh
  1. Correspondence to Dr Sarah Finer; s.finer{at}qmul.ac.uk

Footnotes

  • * DSA and GAH are joint senior authors.

  • MSI, RL and BWO are contributed equally.

  • Twitter Follow Sarah Finer at @Sarah_Finer

  • Contributors DA, GAH and SF conceived and designed the study. SP and DA recruited to and implemented the clinical study. SF and SI transferred samples from ICDDR,B to London, UK and performed DNA extraction and quality control checks. SF, SI, BWO and MS processed DNA for 450k analysis and bisulfite processing. SF analysed the clinical data with help from DA and GAH. RL and CM performed bioinformatics analysis with input from SF, VR and GAH. The manuscript was written by SF with help from BWO, GAH, SI, RL and DA.

  • Funding Medical Research Council (Clinical Research Training Fellowship; reference number G0800441) and ICDDR,B.

  • Competing interests None declared.

  • Ethics approval Ethical approval was obtained via standard institutional procedure (ICDDR,B) ethics review board, and peer review of study protocol at QMUL.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Extra data can be accessed via the Dryad data repository at http://datadryad.org/ with the doi:10.5061/dryad.k67kf.

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Footnotes

  • * DSA and GAH are joint senior authors.

  • MSI, RL and BWO are contributed equally.

  • Twitter Follow Sarah Finer at @Sarah_Finer

  • Contributors DA, GAH and SF conceived and designed the study. SP and DA recruited to and implemented the clinical study. SF and SI transferred samples from ICDDR,B to London, UK and performed DNA extraction and quality control checks. SF, SI, BWO and MS processed DNA for 450k analysis and bisulfite processing. SF analysed the clinical data with help from DA and GAH. RL and CM performed bioinformatics analysis with input from SF, VR and GAH. The manuscript was written by SF with help from BWO, GAH, SI, RL and DA.

  • Funding Medical Research Council (Clinical Research Training Fellowship; reference number G0800441) and ICDDR,B.

  • Competing interests None declared.

  • Ethics approval Ethical approval was obtained via standard institutional procedure (ICDDR,B) ethics review board, and peer review of study protocol at QMUL.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data sharing statement Extra data can be accessed via the Dryad data repository at http://datadryad.org/ with the doi:10.5061/dryad.k67kf.

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