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Neurology
Research
Association study of TREM2 polymorphism rs75932628 with leucoaraiosis or Parkinson's disease in the Han Chinese population
  1. Zhiming Li1,
  2. Li Zhong2,
  3. Long Gu1,
  4. Wenqing Huang1,
  5. Xinzhen Shi2,
  6. Xilin Zhang2,
  7. Xingkai An3,
  8. Qing Lin1,3,
  9. Chi-Meng Tzeng1
  1. 1Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, China
  2. 2Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China
  3. 3Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China
  1. Correspondence to Professor Chi-Meng Tzeng; cmtzeng{at}xmu.edu.cn

Abstract

Objectives The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, in European populations. This study aims to assess the genetic association of the variant rs75932628-T with PD and leucoaraiosis (LA) in a Han Chinese population.

Setting This population-based study was conducted in China by Xiamen University and its affiliated hospital.

Participants 308 patients with LA, 342 patients with PD and 198 healthy blood donors were recruited from the First Affiliated Hospital of Xiamen University.

Outcome measures Genotyping was performed by molecular beacon real-time PCR and Sanger sequencing.

Results None of our participants carried the rs75932628-T mutation.

Conclusions Our results corroborate and extend previous findings, concluding that the variant rs75932628-T (p.R47H) in TREM2 is not a risk factor for LA or PD in the Han Chinese population.

  • Leukoaraiosis
  • rs75932628-T
  • p.R47H
  • Han Chinese population

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2015-009499

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