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This paper was the result of a research protocol drawn up by the senior authors for submission for funding to South African research funding organisations. I was originally invited by the authors to contribute inputs to the planned protocol, the goal of which was to raise the funds to support the research. I was invited to contribute because I am a leading South African authority on the metabolic and health effects of a low carbohydrate diet and I assume the authors believed I could make a contribution that would enhance the probability that the study would be of sufficient value to receive funding. As I recall the original proposal was to have focused principally on the role of carbohydrate ingestion as a risk factor for cancer - a topic about which there are few meta-analyses. Subsequently the focus of the protocol and the review changed somewhat. I reviewed the original research protocol and made specific inputs. I reviewed and commented on the final manuscript that included those comments. That is how I remember the origins of this paper.