Article Text

Progressive resistance training in Parkinson's disease: a systematic review and meta-analysis
  1. Mikhail Saltychev1,
  2. Esa Bärlund2,
  3. Jaana Paltamaa3,
  4. Niina Katajapuu4,
  5. Katri Laimi1
  1. 1Department of Physical and Rehabilitation Medicine, Turku University Hospital and University of Turku, Turku, Finland
  2. 2Satakunta University of Applied Sciences, Pori, Finland
  3. 3School of Health and Social Studies, JAMK University of Applied Sciences, Jyväskylä, Finland
  4. 4Turku University of Applied Sciences, Turku, Finland
  1. Correspondence to Dr Mikhail Saltychev; mikhail.saltychev{at}


Objectives To investigate if there is evidence on effectiveness of progressive resistance training in rehabilitation of Parkinson disease.

Design Systematic review and meta-analysis. Data sources: Central, Medline, Embase, Cinahl, Web of Science, Pedro until May 2014. Randomised controlled or controlled clinical trials. The methodological quality of studies was assessed according to the Cochrane Collaboration's domain-based evaluation framework. Data synthesis: random effects meta-analysis with test for heterogeneity using the I² and pooled estimate as the raw mean difference.

Participants Adults with primary/idiopathic Parkinson's disease of any severity, excluding other concurrent neurological condition.

Interventions Progressive resistance training defined as training consisting of a small number of repetitions until fatigue, allowing sufficient rest between exercises for recovery, and increasing the resistance as the ability to generate force improves.

Comparison Progressive resistance training versus no treatment, placebo or other treatment in randomised controlled or controlled clinical trials.

Primary and secondary outcome measures Any outcome.

Results Of 516 records, 12 were considered relevant. Nine of them had low risk of bias. All studies were randomised controlled trials conducted on small samples with none or 1 month follow-up after the end of intervention. Of them, six were included in quantitative analysis. Pooled effect sizes of meta-analyses on fast and comfortable walking speed, the 6 min walking test, Timed Up and Go test and maximal oxygen consumption were below the level of minimal clinical significance.

Conclusions There is so far no evidence on the superiority of progressive resistance training compared with other physical training to support the use of this technique in rehabilitation of Parkinson's disease.

Systematic review registration number PROSPERO 2014:CRD42014009844.

  • GENERAL MEDICINE (see Internal Medicine)

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