Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)

Sim Yee Ong; Lara Dolling; Jeannette L Dixon; Amanda J Nicoll; Lyle C Gurrin; Michelle Wolthuizen; Erica M Wood; Greg J Anderson; Grant A Ramm; Katrina J Allen; John K Olynyk; Darrell Crawford; Jennifer Kava; Louise E Ramm; Paul Gow; Simon Durrant; Lawrie W Powell; Martin B Delatycki

doi:10.1136/bmjopen-2015-008938

Article info

Gastroenterology and hepatology

Protocol

Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)

Authors

Sim Yee Ong Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Department of Medicine, The University of Melbourne, Parkville, Victoria, Australia PubMed articles Google scholar articles
Lara Dolling Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia PubMed articles Google scholar articles
Jeannette L Dixon Iron Metabolism Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia PubMed articles Google scholar articles
Amanda J Nicoll Department of Gastroenterology, Eastern Health, Box Hill, Victoria, Australia Department of Gastroenterology, Royal Melbourne Hospital, Parkville, Victoria, Australia PubMed articles Google scholar articles
Lyle C Gurrin Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Parkville, Victoria, Australia PubMed articles Google scholar articles
Michelle Wolthuizen Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia PubMed articles Google scholar articles
Erica M Wood Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, Monash University, Prahran, Victoria, Australia PubMed articles Google scholar articles
Greg J Anderson Iron Metabolism Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia PubMed articles Google scholar articles
Grant A Ramm Hepatic Fibrosis Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia PubMed articles Google scholar articles
Katrina J Allen Gastro and Food Allergy, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Allergy and Immunology, Royal Children's Hospital, Parkville, Victoria, Australia PubMed articles Google scholar articles
John K Olynyk Department of Gastroenterology, Fiona Stanley and Fremantle Hospitals, Murdoch, Western Australia, Australia PubMed articles Google scholar articles
Darrell Crawford School of Medicine, University of Queensland, Herston, Queensland, Australia PubMed articles Google scholar articles
Jennifer Kava Department of Gastroenterology, Fiona Stanley and Fremantle Hospitals, Murdoch, Western Australia, Australia PubMed articles Google scholar articles
Louise E Ramm Hepatic Fibrosis Group, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia PubMed articles Google scholar articles
Paul Gow Department of Gastroenterology, Austin Health, Heidelberg, Victoria, Australia PubMed articles Google scholar articles
Simon Durrant Bone Marrow Transplant and Haematology, Royal Brisbane Hospital, Herston, Queensland, Australia PubMed articles Google scholar articles
Lawrie W Powell RBWH Centre for the Advancement of Clinical Research, Royal Brisbane & Women's Hospital, Herston, Queensland, Australia PubMed articles Google scholar articles
Martin B Delatycki Bruce Lefroy Centre, Murdoch Childrens Research Institute, Parkville, Victoria, Australia Clinical Genetics, Austin Health, Heidelberg, Victoria, Australia PubMed articles Google scholar articles

Correspondence to Professor Martin Delatycki; martin.delatycki{at}ghsv.org.au

View Full Text

Citation

Ong SY, Dolling L, Dixon JL, et al

Should HFE p.C282Y homozygotes with moderately elevated serum ferritin be treated? A randomised controlled trial comparing iron reduction with sham treatment (Mi-iron)

BMJ Open 2015;5:e008938. doi: 10.1136/bmjopen-2015-008938

Publication history

Received June 3, 2015
Accepted July 17, 2015
First published August 12, 2015.

Online issue publication

August 12, 2015

Review history

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password