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Cardiovascular medicine
Research
Prevalence and prognostic impact of chronic kidney disease in STEMI from a gender perspective: data from the SWEDEHEART register, a large Swedish prospective cohort
  1. Sofia Sederholm Lawesson1,
  2. Joakim Alfredsson1,
  3. Karolina Szummer2,
  4. Mats Fredrikson3,
  5. Eva Swahn1
  1. 1Department of Cardiology and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
  2. 2Department of Cardiology, Karolinska University Hospital, Huddinge, Institution of Medicine (H7), Karolinska Institutet, Stockholm, Sweden
  3. 3Department of Clinical and Experimental Medicine Division of Occupational and Environmental Medicine and Forum Östergötland Faculty of Medicine and Health Sciences, Linköping University, Linköping,
  1. Correspondence to Dr Sofia Sederholm Lawesson; sofia.lawesson{at}liu.se

Abstract

Objectives Gender differences in prevalence and prognostic impact of chronic kidney disease (CKD) in ST segment elevation myocardial infarction (STEMI) have been poorly evaluated. In STEMI, female gender has been independently associated with an increased risk of mortality. CKD has been found to be an important prognostic marker in myocardial infarction. The aim of this study was to evaluate gender differences in prevalence and prognostic impact of CKD on short-term and long-term mortality.

Design Prospective observational cohort study.

Setting The national quality register SWEDEHEART was used. In the beginning of the study period, 94% of the Swedish coronary care units contributed data to the register, which subsequently increased to 100%. The glomerular filtration rate was estimated (eGFR) according to Modification of Diet in Renal Disease Study (MDRD) and Cockcroft-Gault (CG).

Participants All patients with STEMI registered in SWEDEHEART from the years 2003–2009 were included (37 991 patients, 66% men).

Main results Women had 1.6 (MDRD) to 2.2 (CG) times higher multivariable adjusted risk of CKD. Half of the women had CKD according to CG. CKD was associated with 2–2.5 times higher risk of in-hospital mortality and approximately 1.5 times higher risk of long-term mortality in both genders. Each 10 mL/min decline of eGFR was associated with an increased risk of in-hospital and long-term mortality (22–33% and 9–16%, respectively) and this did not vary significantly by gender. Both in-hospital and long-term mortality were doubled in women. After multivariable adjustment including eGFR, there was no longer any gender difference in early outcome and the long-term outcome was better in women.

Conclusions Among patients with STEMI, female gender was independently associated with CKD. Reduced eGFR was a strong independent risk factor for short-term and long-term mortality without a significant gender difference in prognostic impact and seems to be an important reason why women have higher mortality than men with STEMI.

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/

https://doi.org/10.1136/bmjopen-2015-008188

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    Strengths and limitations of this study

    • The current study included a large number of patients with ST segment elevation myocardial infarction (STEMI), with a sufficient number in each chronic kidney disease stage to assure adequate statistical analyses.

    • SWEDEHEART registry is a unique Swedish National Quality registry, with quality control and audit measures, covering all hospitals in Sweden treating patients with STEMI. SWEDEHEART employs standardised criteria for defining myocardial infarction as well as hospital outcomes.

    • Long-term outcome is complete in Sweden as the vital status of all citizens is registered in the Cause of Death Registry.

    • One of the limitations of SWEDEHEART is its non-randomised, observational nature. Thus multivariate analyses were used in order to reduce the bias inherent in this type of study.

    • The calculations of estimated glomerular filtration rate were based on serum creatinine (s-creatinine) on admission. Thus we cannot exclude inclusion of a few patients with acute renal failure, where the admission s-creatinine may not represent a true estimation of the baseline kidney function.

    Introduction

    During the past decade, chronic kidney disease (CKD) has been found to be one of the most important prognostic markers after myocardial infarction (MI). Even mildly reduced kidney function affects the prognosis in acute coronary syndrome.1–6 As soon as a value of 70–90 mL/min has been reached, each 10 mL decline in estimated glomerular filtration rate (eGFR) increases the risk of mortality by 10–14% post-MI.1 ,6 In addition to prognostic information, it is important to be aware of the presence of CKD in ST segment elevation MI (STEMI), as the majority of patients will undergo primary percutaneous coronary intervention (PCI) with a contrast load that may cause deterioration in an already reduced kidney function. Cardiologists have gradually improved their ability to evaluate kidney function as one part of the overall risk assessment and also to aid in making drug dose adjustments. The Cockcroft-Gault (CG)7 and the Modification of Diet in Renal Disease Study (MDRD)8 formulas are the most widely used, but they differ in several important respects. MDRD is recommended for detecting CKD and CG is recommended for making drug dose adjustments. CG has been shown to be somewhat more predictive of mortality than MDRD after MI.9

    In STEMI, female gender has been independently associated with an increased risk of mortality, especially in the early phase.10–12 Gender differences in the prevalence and prognostic impact of CKD in STEMI have been poorly evaluated in the literature. According to a small single-centre study on patients with STEMI, women had CKD more often than men (67% vs 27%), according to MDRD, and CKD had a stronger prognostic impact in women.13

    Thus the first objective of the present study was to evaluate the prevalence of the different stages of CKD in women and men with STEMI and to examine whether female gender is an independent predictor of CKD. The second objective was to evaluate the prognostic impact of CKD on short-term and long-term mortality, and examine if there is an interaction between gender and CKD regarding prognosis. The third objective was to evaluate if female gender is independently associated with increased short-term and long-term mortality after adjusting for CKD.

    Methods

    Patient population

    All consecutive patients with STEMI admitted to coronary care units (CCUs) between 2003 and 2009 registered in the Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART) register were included in the current study (http://www.ucr.uu.se/swedeheart). The details of the register have been previously published.14 In the beginning of the study period, 94% of the Swedish CCUs contributed with data to the register, increasing to 100% towards the end of the study period.

    SWEDEHEART was also merged with the National Patient Registry (PAR) and the National Death Register. Data on prior comorbidities such as previous MI, diabetes mellitus (DM), stroke, heart failure, dementia, chronic obstructive pulmonary disease (COPD), peripheral artery disease (PAD) and cancer were obtained from the PAR, which collects all discharge diagnoses for patients admitted to a hospital in Sweden since 1987. For the current study, a patient was coded as having one of the mentioned diagnoses if apparent in either SWEDEHEART or PAR. Mortality data were available for all patients and were obtained both from the SWEDEHEART (in-hospital mortality) and the National Death Register (long-term mortality).

    Definitions

    On the basis of serum creatinine (s-creatinine) on admission, GFR was estimated with the MDRD, and Creatinine Clearance with the CG formulas, for all patients where data on sex, age and s-creatinine were available, and regarding CG, also weight.

    Renal dysfunction was staged according to the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF KDOQI) definition; eGFR>90 mL/min/1.73 m2 (normal), 60–90 mL/min/1.73 m2 (mild), 30–59 mL/min/1.73 m2 (moderate), 15–29 mL/min/1.73 m2 (severe) and <15 mL/min/1.73 m2 or receiving dialysis (renal failure).15 CKD stages 4 and 5 were analysed together in the multivariate analysis of the effect of CKD class on mortality, as we had few patients in CKD stage 5, otherwise the classes are presented separately. In order to simplify, the term eGFR will be used for both formulas from here on. CKD is defined as eGFR<60 mL/min(/1.73 m2). In table 1, the MDRD formula is used to define the CKD group.

    GFR estimated according to MDRD in mL/min/1.73 m2=186 * (serum creatinine/88.4 [in µmol/L])−1.154 * age [in years]) −0.203 If women multiply the equation by 0.742

    CrCl according to CG in mL/min=((140- age [in years]) * weight [in kilogram])/(serum creatinine [in µmol/L]) * (88.4/72) If women multiply the equation by 0.85

    View this table:
    Table 1

    Baseline characteristics

    Acute MI was diagnosed using current guidelines during the years of inclusion16 ,17 if troponin T or I or two successive creatine kinase MB (CK-MB) values were above the 99th percentile for the reference population within 24 h of the index clinical event, or if the CK-MB value was twice above the decision limit. STEMI was defined as having a significant ST segment elevation on arrival-ECG together with the diagnosis of MI on discharge, that is, patients with left bundle branch block or pacemaker-ECG on admission were excluded. If a patient was registered with MI several times in SWEDEHEART, only the first occasion was counted.

    Ethics

    All patients for whom data are entered into the SWEDEHEART register are informed of their participation and their right to deny participation or have data removed later, in accordance to Swedish legislation. Data used for research purpose have all personal identifiers removed. The registry and the merging of registries are approved by the Swedish National Board of Health and Welfare.

    Statistics

    Continuous variables were summarised by their mean and SD, or median and IQR, as appropriate. Categorical variables were summarised by counts and percentages. Comparisons between different groups were performed by χ2 tests for categorical variables and by Student t test or Mann-Whitney test for continuous variables. p Values <0.05 were considered to indicate statistical significance.

    Crude and multivariable ORs with 95% CIs were calculated from logistic regression analyses in order to compare men and women as regards risk of having CKD. Variables incorporated in the model were: gender, age, smoking, previous MI, PCI, coronary artery bypass grafting, stroke, hypertension, DM, COPD, heart failure, PAD, dementia, cancer within 3 years, and therapy on arrival (aspirin, other platelet inhibitors, oral anticoagulants, β-blockers, ACE inhibitors, angiotensin receptor blockers (ARB), statins, calcium-channel blockers (CCB), diuretics, digitalis and long-acting nitrates).

    Crude and multivariable adjusted ORs and HRs with 95% CI were calculated using logistic and Cox proportional hazard regression analyses in order to evaluate the impact of eGFR on in-hospital and long-term mortality, respectively. Men and women were analysed separately. The same variables as above (except gender) were used with the addition of interventional hospital, year of inclusion, reperfusion therapy and Killip class regarding in-hospital mortality and also discharge therapy regarding long-term mortality. Kaplan-Meier survival curves were plotted for men and women in four CKD categories, according to MDRD and CG, respectively. Wilcoxon (Gehan) Statistics were used for comparisons between the CKD groups.

    Finally, a possible interaction between gender and eGFR regarding mortality was evaluated incorporating an interaction term (ie, the product of gender and eGFR) into logistic and Cox regression models, respectively, together with gender and eGFR and all other covariates.

    All statistical analyses were performed with SPSS V.18.0 (PASW Statistics V.18) software (SPSS Inc, Chicago, Illinois, USA).

    Results

    Basic characteristics

    A total of 37 991 patients were included in the analyses, 25 062 (66%) men and 12 929 (34%) women. Women were older, had lower weight, body mass index (BMI), heart rate and Killip class on admission. They also had a higher prevalence of comorbidities such as diabetes, hypertension, COPD, PAD, previous stroke or dementia whereas men were more often smokers, had more often suffered from a previous MI and had more often been previously revascularised (table 1).

    Complete data were available for 35 352 (93%) patients regarding MDRD and 26 586 (70%) patients regarding CG.

    Patients with CKD, men and women, were older, had lower weight, BMI and systolic blood pressure but higher heart rate on admission, compared with patients with without CKD. The prevalence of cardiovascular risk factors and diseases, such as diabetes, hypertension, previous stroke, PAD, chronic heart failure or previous MI were higher in the patients with CKD but they were half as often smokers compared with the patients without CKD. Almost half of the CKD men and women were already on treatment with aspirin or β-blockers on admission. They had higher plasma glucose on admission and lower haemoglobin and cholesterol levels. They much more often had signs of heart failure including cardiogenic shock or pulmonary oedema and all complications during hospital care were more common among patients with CKD of both genders. Around 70% of the women and 50% of the men with CKD had left ventricular dysfunction (ejection fraction <50%) compared with half of the men and women without CKD. They had a lower chance of reperfusion therapy or angiography during hospital care and less often received evidence-based cardiovascular therapies such as platelet inhibitors or statins at the time of discharge (table 1).

    Differences between men and women in kidney function

    Mean s-creatinine on admission was higher in men whereas mean eGFR was lower in women regardless of formula. Mean eGFR was 69 and 66 mL/min in women compared with 81 and 88 mL/min in men, using MDRD and CG formulas, respectively (table 1). About 19% and 22% of men versus 38% and 50% of women had CKD according to the MDRD and CG formulas, respectively. Among men, 33% and 45% were in the best CKD stage compared with 20% and 19% among women according to both formulas. In the youngest group, more than 90% of men and 75% of women were in CKD stage 1 compared with only a few per cent of men and women in the oldest group according to CG (figure 1 and table 2).

    View this table:
    Table 2

    Prevalence of CKD stage 1–5 in women and men, MDRD and CG

    Figure 1
    Figure 1

    Chronic kidney disease (CKD) stages according to Modification of Diet in Renal Disease Study (MDRD) (left) and Cockcroft-Gault (CG) (right) in five age-groups.

    After adjustment for age, women had 1.6 and 2.2 times higher risk of having CKD with the MDRD and CG formula, respectively, which did not change after multivariable adjustment. The odds of being classified as having CKD were significantly higher when the CG was used instead of the MDRD formula. This result persisted even when cut-points for mild (eGFR<90 mL/min/1.73 m2) or severe (eGFR<30 mL/min/1.73 m2) CKD were used (table 3).

    View this table:
    Table 3

    Risk of chronic kidney disease in women compared with men

    Outcome, CKD versus non-CKD

    Nineteen per cent of women with CKD compared with 5% of women without CKD died during hospital care. The corresponding figures in men were 15% vs 3%. During follow-up, 52% of women with CKD died compared with 20% of women without CKD. Corresponding figures in men were 46% vs 13%. In both genders, after multivariable adjustments, in-hospital and long-term mortality gradually increased per 10 mL decline of eGFR and per incline in CKD stage according to both formulas (table 4 and figure 2). There was no significant interaction between gender and eGFR regarding in-hospital mortality (MDRD, p=0.07/CG, p=0.44) or long-term mortality (MDRD, p=0.83/CG, p=0.56).

    View this table:
    Table 4

    Influence of reduced eGFR on short-term and long-term mortality

    Figure 2
    Figure 2

    Kaplan-Meier survival curves per chronic kidney disease (CKD) stages, women and men. Comparisons between CKD groups, Wilcoxon (Gehan) Statistics, p<0.001 for all comparisons except between CKD 4 and 5 in men (p=0.40 and 0.30, Modification of Diet in Renal Disease Study (MDRD) and Cockcroft-Gault (CG), respectively).

    Outcome, women versus men

    Women had more than doubled in-hospital and almost doubled long-term mortality than men. After adjustment for age, women still had 22% higher risk of in-hospital and 6% higher risk of long-term mortality. After multivariable adjustments including all confounders except kidney function, women still had 11% higher risk of in-hospital mortality but men had 7% higher risk of long-term mortality. If eGFR according to any of the formulas was also included, there was no longer a gender difference regarding in-hospital mortality, and women had a lower risk of long-term mortality. Adjusting for eGFR according to CG alone was enough to eradicate the higher risk in women, both short-term and long term, and changed the OR and HR more than the multivariable analyses that did not include kidney function (figure 3).

    Figure 3
    Figure 3

    Logistic and Cox proportional hazard regression models of in-hospital and long-term mortality. OR and HR with 95% CIs, women versus men (CG, Cockcroft-Gault; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease Study).

    Sensitivity analysis

    We also performed analyses on the limited population where CG was possible to estimate (70%=26 586). The results were very similar (see online supplementary tables S1–S4).

    Discussion

    The key findings in this study were that the prevalence of CKD in women with STEMI was very high and female gender was independently associated with CKD at admission in STEMI. In addition, reduced kidney function per 10 mL/min decline in eGFR regardless of the formula used was a strong and independent risk factor for short-term and long-term mortality in both genders without a significant gender difference in prognostic impact. Reduced GFR appeared to be an important reason why women had doubled mortality compared with men with STEMI.

    Earlier studies have shown that in-hospital mortality varies from 1% in patients with normal kidney function (CKD stage 1) to 12–35% in those with severe renal dysfunction (CKD stage 4–5).2 ,6 CKD, defined as eGFR below 60 mL/min, has also been shown to be more common in patients with MI with prevalence around 30%1 ,2 ,6 compared with 6–8% in the general population.18 ,19 We found a remarkably high prevalence of CKD in women with STEMI. According to the Health Survey of Nord-Trondelag County (HUNT II) study, 5.7% of women and 3.6% of men in the general Nordic population have CKD stage 3–4 according to MDRD.18 The corresponding figures in our cohort were 38% and 19% of women and men, respectively. If we instead used the CG formula, which has been shown to better predict outcome in patients with MI than MDRD,9 as many as half of the women had CKD compared with 22% in men. There was a remarkable impact of age on CKD prevalence, especially when CG was used (figure 1).

    Thus we thought it important to analyse the association between eGFR and outcome in both genders. Although women with STEMI have a worse outcome than men,10–12 few studies have investigated the role of renal impairment. Two small single-centre studies, one including mixed patients with coronary artery disease (CAD) undergoing coronary angiography and one including patients with STEMI undergoing primary PCI, found a very high prevalence of CKD in women, based on the MDRD formula (67% vs 70%). Even more remarkable was that both studies found a stronger prognostic impact of CKD in women compared with men,13 ,20 something that we could not confirm in our study. We found no interaction between gender and eGFR with either of the formulas, neither on short-term nor long-term mortality. After multivariable adjustment, there was approximately 10% and 30% increased risk of short-term and long-term mortality per 10 mL decline in eGFR in both genders with both formulas. A possible explanation for the contradictory findings compared with the previous studies could be the higher prevalence of CKD in women compared with the present study, and differences in comorbidities and multivariate adjustments. In the STEMI study, there were few men with advanced CKD and thus few events in this group, which could explain the discrepant results. As both these previous studies were small, their findings could also be a matter of chance. The magnitude of the present study gave us better power to explore the influence of renal function in relation to gender.

    In the present study, women had doubled in-hospital mortality compared with men. After adjusting for baseline differences including 27 covariates, women still had 11% higher risk of in-hospital mortality, consistent with previous findings.10–12 When eGFR according to any of the two formulas was adjusted for, there was no longer any gender difference in early mortality. In fact, adjusting for eGFR according to CG alone reduced the OR of in-hospital death from 2.12 (95% CI 1.96 to 2.29) to 0.99 (95% CI 0.87 to 1.11). Further adjustment did not alter the results substantially. Regarding long-term mortality, the same pattern was seen.

    The higher prevalence of CKD in women could thus explain, to a great extent, the gender difference in mortality. It is likely, by adjusting for renal function alone, that several more adjustments can be made, as many risk factors, such as hypertension and diabetes, and especially age, covary with renal function both in men and women.1 ,6 The difference in adjustments was more pronounced with the CG formula than with the MDRD formula. Even though the two renal function equations both incorporate age in the equation, they handle the variables differently mathematically. In the present study, we could show that prognosis following an MI, both short-term and long term, is better described by the CG formula in men and women, and this is consistent with previous studies.9 It is, however, unknown which of the two formulas better reflects the true underlying renal function in the STEMI population. The most accurate way to measure kidney function is to measure GFR with an injected exogenous marker such as, for example, iohexol. In clinical practice, this is too cumbersome and, instead, estimating GFR has become routine practice. Neither of the two most common formulas were developed for cardiac patients. The CG formula was developed in the 1970s from a cohort of 249 men treated for a variety of diseases at medical wards7 and the MDRD formula was developed in the 1990s from a cohort of 1628 patients with CKD of both genders.8 They differ somewhat in their estimations in populations with varying gender, age and weight, and are recommended for different purposes: CG for dose adjustments, MDRD for detection of CKD. In spite of MDRD being developed on both genders but CG only in men, it has been shown that the relative error (bias) of CG predictions is associated with age and BMI but not with gender, whereas MDRD has been found to underestimate GFR in women. Equations for prediction of kidney function include a correction factor that lowers the prediction in women to compensate for the gender-dependent difference in creatinine (ie, muscular mass). The difference in muscular mass between men and women was found to be adequately predicted by the CG but overestimated by MDRD according to a study by Cirillo et al.21 In the same study, the authors hypothesise that the strong influence on renal function using the CG formula could partly be due to an overestimation of the association of ageing with decline of muscular mass. This could be an additional factor explaining the very high prevalence of CKD in women in our study, as they are clearly older than the men.

    The reason for the poor outcome in patients with concomitant STEMI and CKD is multifactorial.22 It is well known that patients with CKD have a higher prevalence of risk factors such as DM and hypertension.23 Owing to the lower renal function in women, a higher proportion of women compared with men are at risk of contrast-induced nephropathy after PCI. Undertreatment with less reperfusion in women than men with CKD in our study (53.7% vs 84.3% in women and men, respectively) and other evidenced-based therapies also contribute to the reduced survival.24–26 This gender difference in evidence-based STEMI treatment has been shown before, even in the modern era.27 As an increased risk of major bleeding has been found in women treated with fibrinolytics,28 and CKD is also a predictor of bleeding,29 a fear of these dreadful complications may explain some of the observed difference. Other potential explanations could be the longer delay times in women and a higher prevalence of non-obstructive CAD.27 In our study, the chance of having a coronary angiography performed as well as other evidence-based therapies was lower in patients with CKD, something we adjusted for in the multivariate analysis. The lower use of invasive therapies could be explained by scarce evidence-based data, and a lack of proven efficiency in this group of patients. It is also unknown to what extent CKD was identified in patients with STEMI. The lack of recognition of CKD could represent a missed opportunity for dose adjustment of medications. Many patients with CKD and STEMI may have been treated without any dose-reduction in, for example, glycoprotein IIb/IIIa inhibitors, with more bleeding events as a consequence. It is possible that more women were exposed to higher doses, as they are often older and weigh less. In addition, CKD is associated with several metabolic abnormalities, such as oxidative stress, hypoalbuminaemia, hyperhomocysteinaemia, hyperfibrinogenaemia, insulin resistance, lipid abnormalities, inflammation and derangements in the calcium–phosphate homeostasis, all possibly contributing to an excessive cardiovascular risk.30–34

    Conclusion

    Impaired renal function is extremely common in women with STEMI—in fact, half of all women with STEMI had at least moderate renal dysfunction. This is far more common than in the general population. The presence of CKD indicated doubled risk of in-hospital mortality in both genders, and reduced eGFR was found to be a strong and independent risk factor for early and late mortality with equal prognostic impact in both genders. Reduced eGFR appeared to be an important reason why women with STEMI had doubled mortality compared with men with STEMI.

    Acknowledgments

    The authors acknowledge all participating hospitals for their help and cooperation, and for contributing data to the SWEDEHEART registry.

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    Supplementary materials

    • Supplementary Data

      This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

    Footnotes

    • Contributors SSL was responsible for the conception and design of the study, analysed and interpreted the data, and drafted the manuscript. JA, KS and ES were responsible for the conception and design of the study, critically revised the manuscript and added important intellectual content. MF critically revised the manuscript from a statistical perspective and added intellectual content. All the authors approved the submission of the manuscript.

    • Funding The SWEDEHEART register is supported by the National Board of Health and Welfare, the Swedish Society of Cardiology, and the Swedish Association of Local Authorities and Regions.

    • Competing interests None declared.

    • Ethics approval The present study complies with the Declaration of Helsinki and was approved by the Ethics Committee in Uppsala.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement Technical appendix, statistical code and data set are available from the authors whenever needed.