Article Text

Effect of vegetable consumption on the association between peripheral leucocyte telomere length and hypertension: a case–control study
  1. Fuzhi Lian1,
  2. Jinquan Wang2,
  3. Xianhong Huang1,
  4. Yinyin Wu1,
  5. Yifei Cao1,
  6. Xiaohua Tan1,
  7. Xianrong Xu1,
  8. Yu Hong1,
  9. Lei Yang1,2,
  10. Xiang Gao3
  1. 1School of Medicine, Hangzhou Normal University, Hangzhou, Zhejiang Province, China
  2. 2School of Life Science, Shihezi University, Shihezi, Xinjiang Uighur Autonomous Region, China
  3. 3Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA
  1. Correspondence to Dr Fuzhi Lian; Fuzhi.Lian{at} and Dr Xiang Gao; xxg14{at}


Objectives Peripheral leucocyte telomere length has been suggested to be inversely associated with hypertension risk. Both telomere length and hypertension risk can be modified by certain dietary factors, such as fruit and vegetables. This study was to examine the potential effect of these dietary factors on the association between telomere length and hypertension risk.

Study design A community-based case–control study.

Participants 271 hypertensive patients and 455 normotensive controls aged 40–70 years and living in Yinzhou, Zhejiang Province, China.

Outcome measures Peripheral leucocyte relative telomere length (RTL) was measured using quantitative real-time PCR. Dietary intake was assessed by a brief semiquantitative food frequency questionnaire. The association between RTL and hypertension risk was analysed using logistic regression, and the modulatory effect of dietary intake on RTL-related hypertension risk was analysed using likelihood ratio tests.

Results Among controls, longer age-adjusted RTL was associated with higher vegetable intake (p=0.01). Individuals with longer age-adjusted RTL (based on median value) were 30% less likely to have hypertension (OR=0.70, 95% CI 0.52 to 0.96; p=0.03). The observed RTL-hypertension relationship appeared to be modified by vegetable intake—longer RTL was significantly associated with lower hypertension risk only in those with greater vegetable consumption (OR=0.28, 95% CI 0.14 to 0.57; p<0.001), but not in those with lower vegetable intake (P-interaction=0.008).

Conclusions Certain dietary factors might modify telomere-related hypertension risk.


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