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Impact of infectious diseases consultation on the management of Staphylococcus aureus bacteraemia in children
  1. Rebecca B Saunderson1,
  2. Theodore Gouliouris1,2,3,
  3. Edward J Cartwright1,3,
  4. Emma J Nickerson4,
  5. Sani H Aliyu2,4,
  6. D Roddy O'Donnell5,
  7. Wilf Kelsall5,
  8. D Limmathurotsakul6,
  9. Sharon J Peacock1,2,3,7,
  10. M Estée Török1,2,3
  1. 1Department of Medicine, University of Cambridge, Cambridge, UK
  2. 2Department of Microbiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  3. 3Public Health England, Clinical Microbiology and Public Health Laboratory, Cambridge, UK
  4. 4Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  5. 5Department of Paediatrics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK
  6. 6Mahidol Oxford Research Unit, Mahidol University, Bangkok, Thailand
  7. 7Wellcome Trust Sanger Institute, Hinxton, UK
  1. Correspondence to Dr M Estée Török; et317{at}medschl.cam.ac.uk

Abstract

Objectives Infectious diseases consultation (IDC) in adults with Staphylococcus aureus bacteraemia (SAB) has been shown to improve management and outcome. The aim of this study was to evaluate the impact of IDC on the management of SAB in children.

Study design Observational cohort study of children with SAB.

Setting Cambridge University Hospitals National Health Service (NHS) Foundation Trust, a large acute NHS Trust in the UK.

Participants All children with SAB admitted to the Cambridge University Hospitals NHS Foundation Trust between 16 July 2006 and 31 December 2012.

Methods Children with SAB between 2006 and 31 October 2009 were managed by routine clinical care (pre-IDC group) and data were collected retrospectively by case notes review. An IDC service for SAB was introduced in November 2009. All children with SAB were reviewed regularly and data were collected prospectively (IDC group) until 31 December 2012. Baseline characteristics, quality metrics and outcome were compared between the pre-IDC group and IDC group.

Results There were 66 episodes of SAB in 63 children—28 patients (30 episodes) in the pre-IDC group, and 35 patients (36 episodes) in the IDC group. The median age was 3.4 years (IQR 0.2–10.7 years). Patients in the IDC group were more likely to have echocardiography performed, a removable focus of infection identified and to receive a longer course of intravenous antimicrobial therapy. There were no differences in total duration of antibiotic therapy, duration of hospital admission or outcome at 30 or 90 days following onset of SAB.

Conclusions IDC resulted in improvements in the investigation and management of SAB in children.

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/3.0/

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