Article Text

Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials
  1. Ju Ah Lee1,
  2. Mi Ju Son2,
  3. Jiae Choi1,
  4. Ji Hee Jun1,
  5. Jong-In Kim3,
  6. Myeong Soo Lee1
  1. 1Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea
  2. 2Medical Culture & Informatics Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea
  3. 3Division of Acupuncture & Moxibustion Medicine, Kyung Hee Korean Medicine Hospital, Kyung Hee University, Seoul, South Korea
  1. Correspondence to Dr Myeong Soo Lee; drmslee{at}


Objective To assess the clinical evidence for bee venom acupuncture (BVA) for rheumatoid arthritis (RA).

Design Systematic review of randomised controlled trials (RCTs).

Setting We searched 14 databases up to March 2014 without a language restriction.

Participants Patients with RA.

Intervention BVA involved injecting purified, diluted BV into acupoints. We included trials on BVA used alone or in combination with a conventional therapy versus the conventional therapy alone.

Primary outcomes Morning stiffness, pain and joint swelling

Secondary outcomes Erythrocyte sedimentation rate (ESR), C reactive protein (CRP), rheumatoid factor, the number of joints affected by RA and adverse effects likely related to RA.

Results A total of 304 potentially relevant studies were identified; only one RCT met our inclusion criteria. Compared with placebo, BVA may more effectively improve joint pain, swollen joint counts, tender joint counts, ESR and CRP but was not shown to improve morning stiffness.

Conclusions There is low-quality evidence, based on one trial, that BVA can significantly reduce pain, morning stiffness, tender joint counts, swollen joint counts and improve the quality of life of patients with RA compared with placebo (normal saline injection) control. However, the number of trials, their quality and the total sample size were too low to draw firm conclusions.

Trial registration number PROSPERO 2013: CRD42013005853.


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