Article Text

Download PDFPDF

Herbal medicine (Gan Mai Da Zao decoction) for depression: a systematic review protocol
  1. Ji Hee Jun1,
  2. Ju Ah Lee1,
  3. Tae-Young Choi1,
  4. Kyung-Jin Yun1,
  5. Hyun-Ja Lim2,
  6. Myeong Soo Lee1
  1. 1Medical Research Division, Korea Institute of Oriental Medicine, Daejeon, South Korea
  2. 2Department of Nursing, Chodang University, Muan, South Korea
  1. Correspondence to Dr Myeong Soo Lee; drmslee{at}


Introduction The aim of this systematic review is to analyse trial data on the effectiveness of a herbal medicine (Gan Mai Da Zao (GMDZ) decoction) in treating depression.

Methods and analysis 12 databases will be searched from their inception: PubMed, EMBASE, AMED, the Cochrane Library, five Korean medical databases (KoreaMed, DBpia, OASIS, the Research Information Service System (RISS) and the Korean Studies Information Service System (KISS)) and three Chinese medical databases (China National Knowledge Infrastructure (CNKI), the Wanfang Database and the Chinese Scientific Journals Database (VIP)). Randomised clinical trials (RCTs) or quasi-RCTs using a GMDZ decoction for any type of depression will be considered. The selection of the studies, data abstraction and validations will be performed independently by two researchers.

Dissemination The findings will be disseminated to appropriate audiences via peer-reviewed publication and conference presentations.

Trial registration number PROSPERO 2013:CRD42013005100.


This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:

View Full Text

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.