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Neurology
Research
Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT study, Norway
  1. Line M Jacobsen1,
  2. Bendik S Winsvold1,2,
  3. Solfrid Romundstad3,4,
  4. Are H Pripp5,
  5. Jostein Holmen6,
  6. John-Anker Zwart1,2,7
  1. 1FORMI, Oslo University Hospital, Oslo, Norway
  2. 2Department of Neurology, Oslo University Hospital, Oslo, Norway
  3. 3Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
  4. 4Department of Internal Medicine, Levanger Hospital, Health Trust Nord-Trøndelag, Levanger, Norway
  5. 5Department of Biostatistics, Epidemiology and Health Economy, Oslo University Hospital, Oslo, Norway
  6. 6Department of Public Health and General Practice, HUNT Research Centre, Norwegian University of Science and Technology, Levanger, Norway
  7. 7Institute of Clinical Medicine, University of Oslo, Norway
  1. Correspondence to Dr Line Melå Jacobsen; linemjaco{at}gmail.com

Abstract

Objective To investigate urine albumin leakage as a marker of endothelial dysfunction in migraine patients.

Design A population-based health study.

Participants 303 patients with migraine, 1009 patients with non-migraine headache and 5287 headache-free controls.

Outcomes The association between urine albumin- to-creatine ratio (ACR) and headache status was investigated in the Nord-Trøndelag Health Study (HUNT-2). Patients were selected in two strata, based on either (1) self-reported hypertension/diabetes (morbid sample) or (2) a random sample. Analyses were performed using analysis of covariance.

Results There was no association between headache status and ACR in the study population (p=0.23, mean ACR for migraine 1.66, 95% CI 1.31 to 2.01, for non-migraine headache 1.90, 95% CI 1.71 to 2.09 and for no headache 1.73, 95% CI 1.64 to 1.81) after relevant adjustments. Similarly, no association between headache status and ACR was seen when the analysis was stratified for morbid and random samples, or for migraine with and without aura.

Conclusions We found no evidence of increased urine albumin leakage in migraine sufferers when compared with headache-free controls. This could indicate that systemic endothelial dysfunction is not a prominent feature of migraine.

  • Vascular Medicine

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

https://doi.org/10.1136/bmjopen-2013-003268

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