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Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients
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  • Published on:
    Incorrect trial number; correct number is NCT00368199

    Our paper has the trial number NCT0036819, and it should read NCT00368199 (See https://clinicaltrials.gov/ct2/show/NCT00368199).

    Conflict of Interest:

    None declared

    Conflict of Interest:
    None declared.
  • Published on:
    Re:Response to "Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients"
    • Wim E.J. Weber, Associate Professor
    • Other Contributors:
      • Angela Bouwmans, Annemarie Vlaar, Werner Mess, Alfons Kessels

    We would like to thank drs Mahlknecht, Seppi, and Berg for compliments on a study well designed and executed.

    They do, however, raise two major and one minor criticism to our study.

    Firstly, the DAT-SPECT data in our study were not in accordance with the clinical data, suggesting 'that clinical classification of the patients was suboptimal'. Secondly, the TCS data were disappointing, because, among o...

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    Conflict of Interest:
    None declared.
  • Published on:
    Response to "Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson's disease: prospective cohort study in 196 patients"

    The study by Bouwmans and colleagues seems to be well designed and thoroughly executed [1], but the primary results are surprising regarding both the transcranial sonography (TCS) and dopamine transporters - single- photon emission computed tomography (DAT-SPECT) results. According to large scale prospective studies, DAT-SPECT should have a specificity close to 100% in differentiating neurodegenerative parkinsonian syndrom...

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    Conflict of Interest:
    None declared.