Article Text

Download PDFPDF

The contribution of stress to the comorbidity of migraine and major depression: results from a prospective cohort study
  1. Sonja A Swanson1,
  2. Yiye Zeng2,
  3. Murray Weeks3,
  4. Ian Colman2,3
  1. 1Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
  2. 2Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
  3. 3Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
  1. Correspondence to: Dr Ian Colman; icolman{at}uottawa.ca

Abstract

Objectives To assess how much the association between migraine and depression may be explained by various measures of stress.

Design National Population Health Survey is a prospective cohort study representative of the Canadian population. Eight years of follow-up time were used in the present analyses.

Setting Canadian adult population ages 18–64.

Participants 9288 participants.

Outcome Incident migraine and major depression.

Results Adjusting for sex and age, depression was predictive of incident migraine (HR: 1.62; 95% CI 1.03 to 2.53) and migraine was predictive of incident depression (HR: 1.55; 95% CI 1.15 to 2.08). However, adjusting for each assessed stressor (childhood trauma, recent marital problems, recent unemployment, recent household financial problems, work stress, chronic stress and change in social support) decreased this association, with chronic stress being a particularly strong predictor of outcomes. When adjusting for all stressors simultaneously, both associations were largely attenuated (depression–migraine HR: 1.30; 95% CI 0.80 to 2.10; migraine–depression HR: 1.19; 95% CI 0.86 to 1.66).

Conclusions Much of the apparent association between migraine and depression may be explained by stress.

  • Epidemiology

this is an open-access article distributed under the terms of the creative commons attribution non-commercial license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. see: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

View Full Text

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.