Objectives We performed a re-analysis of the data from Navarro et al (2003) in which health symptoms related to microwave exposure from mobile phone base stations (BSs) were explored, including data obtained in a retrospective inquiry about fear of exposure from BSs.
Design Cross-sectional study.
Setting La Ñora (Murcia), Spain.
Participants Participants with known illness in 2003 were subsequently disregarded: 88 participants instead of 101 (in 2003) were analysed. Since weather circumstances can influence exposure, we restricted data to measurements made under similar weather conditions.
Outcomes and methods A statistical method indifferent to the assumption of normality was employed: namely, binary logistic regression for modelling a binary response (eg, suffering fatigue (1) or not (0)), and so exposure was introduced as a predictor variable. This analysis was carried out on a regular basis and bootstrapping (95% percentile method) was used to provide more accurate CIs.
Results The symptoms most related to exposure were lack of appetite (OR=1.58, 95% CI 1.23 to 2.03); lack of concentration (OR=1.54, 95% CI 1.25 to 1.89); irritability (OR=1.51, 95% CI 1.23 to 1.85); and trouble sleeping (OR=1.49, 95% CI 1.20 to 1.84). Changes in –2 log likelihood showed similar results. Concerns about the BSs were strongly related with trouble sleeping (OR =3.12, 95% CI 1.10 to 8.86). The exposure variable remained statistically significant in the multivariate analysis. The bootstrapped values were similar to asymptotic CIs.
Conclusions This study confirms our preliminary results. We observed that the incidence of most of the symptoms was related to exposure levels—independently of the demographic variables and some possible risk factors. Concerns about adverse effects from exposure, despite being strongly related with sleep disturbances, do not influence the direct association between exposure and sleep.
- Public Health
- Occupational & Industrial Medicine
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Strengths and limitations of this study
We used a robust statistical analysis with a highly homogeneous sample in a homogeneous environment.
A participation bias cannot be ruled out. The late query about concerns (as a possible confounder) may render the results less valid.
We observed that the incidence of most of the symptoms was related to exposure levels.
The health risk due to exposure to radiofrequency electromagnetic fields (RF EMFs) continues to be discussed today. The study that led to this debate was initiated after verification that the US embassy in Moscow was being subjected to such radiation from 1953 to May 1975.1 Recently, a review of that episode2 reopened the debate about the potential harmfulness of RF EMFs. The increasing number of base stations (BSs) on masts and buildings has increased public awareness. This issue has prompted scientific research to establish to what extent low-intensity EMFs may affect the health of humans and other organisms.3 ,4 Furthermore, the term electromagnetic hypersensitivity has been recently introduced in discussions attributing symptoms to exposure to EMFs.5–8 A review of this topic9 in 2010 found that 8 of the 10 studies evaluated through PubMed had reported increased prevalence of adverse neurobehavioral symptoms or cancer in populations living at distances <500 m from BSs.
None of the studies reported exposure above accepted international guidelines, suggesting that current guidelines may be inadequate in protecting health. Thus, the need emerges to revaluate our pioneering work in this field in order to add new procedures and data. Few articles have addressed the possible association between microwave sickness and microwave exposure from Global System for Mobile Communications (GSM) BSs since the publication of our first study.10 Chronologically, Santini et al11 and Gadzicka et al12 reported differences in the distance-dependent prevalence of symptoms such as headache, impaired concentration and irritability. A later Austrian study13 showed a positive association between the measured electrical field (GSM 900/1800) in bedrooms and headaches, cold hands and feet and difficulties in concentration. An Egyptian study14 showed a prevalence of neurological symptoms, such as headache, memory changes, dizziness, tremors, depressive symptoms and sleep disturbances among participants directly exposed to GSM signals from BSs.
The symptoms reported by all the above cited authors belong to those attributed to the microwave syndrome.15 However, one article16 using personal monitored data from GSM-UMTS frequency bands found no statistical association in adults. More recently, the same authors observed no association in children,17 contradictory results in children and adolescents,18 and concluded that the few observed significant associations were not causal but rather occurred by chance. Blettner et al19 reported in phase 1 of their study more health problems closer to BSs, but in phase 220 they concluded that measured EMF emissions were not related to adverse health effects.
Other researchers focused their work on the possible existence of participants with sensitivity to GSM or UMTS signals according to psychological, cognitive or autonomic assessment. These researchers used short-term exposure (only 30–50 min) under laboratory conditions21–23 and revealed a large disparity between participants. Recently, a study measuring several biological stress markers24 found that RF EMF emitted by mobile phone BSs from 5.2 to 2126.8 μW/m2 increased cortisol and salivary α-amylase, while IgA concentration was not significantly modified.
The Selbitz study25 in 2010 described a significant dose–response relationship in symptoms related with sleep, mood, joints, infections, skin condition, as well as neurological, cardiovascular, visual and auditory systems and the gastrointestinal tract.
The existence of short-term physiological effects of EMF on sleep quality was not evident in the work of Danker-Hopfe et al26; however, it was stated that the presence of BSs per se (not the EMF) may have a negative impact on sleep quality.
A Polish study in 2012 did not show a correlation between electrical field strength and frequency of subjective symptoms; however, it showed a correlation between subjective symptoms and the distance to BSs.27 A study carried out in Egypt28 revealed that exposure to EMF emitted either from mobile phones or BSs had significant effects on the pituitary–adrenal axis. More recently, work developed in Iran29 indicated that symptoms such as nausea, headache, dizziness, irritability, discomfort, nervousness, depression, sleep disturbance, memory loss and lowering of libido were statistically significant in people living near BSs (<300 m distances) compared with those living far from the BSs (>300 m).
In our cross-sectional analysis,10 11 of 16 symptoms showed statistically significant higher scores in the group with the maximum exposure level. The symptoms are included in the microwave syndrome. We also reported statistically significant correlation coefficients between the measured electrical field and 14 of 16 symptoms.
A review30 recently established several conditions for epidemiological studies to be eligible for introduction in general analysis: eligible studies must quantify exposure using objective measures (such as distance to the nearest BS, spot or personal exposure measurements in a specific frequency range); possible confounders must be considered and the selection of the study population must be clearly free of bias in terms of exposure and outcomes.
Accordingly, in this reanalysis of our previous study,10 possible confounders were included in addition to the specific RF EMF measurements made in 2001 (covering the specific range between 900 and 1800 MHz). Therefore, we coanalysed the effects of other variables such as sociodemographic data and the use of electronic devices. Concern about being damaged by radiation from antennas was also analysed.
The new statistical approach tested the possible influences of other variables, such as demographic data and the use of electronic devices. Moreover, since some concerns have been raised about possible health consequences caused by the emitted microwaves, we analysed whether these symptoms might be related to fear of exposure. As some participants refused to allow measurements in their homes, we analysed whether symptom status or subjective distance to the BS could be a bias of participation in the study. Interestingly, this period was free of other sources of RF such as WIFI or UMTS or the massive use of mobile phones, enabling a specific study of GSM technology. Finally, the suitability of the size of the sample was analysed.
We chose a small urban area with mixed rural characteristics: low levels of environmental pollution (more agricultural than industrial); no major differences in socioeconomic characteristics throughout the region (excluding large cities); similar ethnicity (white Caucasian) and language (Spanish) and with mobile phone communication operative for at least 2 years. La Ñora was chosen because it had the features of a small city, and was located near the capital (Murcia) in a rural environment without any particular health or environmental problems. Consequently, La Ñora was representative of small urban areas in eastern Spain with fewer than 20 000 inhabitants—such rural areas accounting for 19.8% of the population and 35.9% of the territory in Spain.
Two BS masts, each about 30 m height, were sited at different positions to provide GSM-900-1800 coverage. The GSM 900 BS was positioned not before 1997 while the GSM 1800 BS was built in December 1999.
Data regarding the main demographic characteristics of the sample and their use of electronic devices was collected through a Spanish-language questionnaire.11 All of the participants were of the same ethnic origin, shared similar family income levels and general standard of living, and were born in La Ñora or nearby. All the residents in the study were living in the village before the erection of both BSs. All of the residents were at home for more than 8 h a day for at least 6 days a week and normally slept at home.
The core of the questionnaire was a symptom checklist for estimating the frequency of 15 health-related symptoms attributed to microwave sickness. These symptoms were fatigue, irritability, headaches, nausea, loss of appetite, sleep disorders, depressive tendency, dizziness, concentration difficulties, memory loss, skin lesions, visual and hearing deficiencies, walking difficulties and cardiovascular problems. The frequency was quantified as never suffer = 0, sometimes = 1, often = 2 and very often =3.
The percentage of residents who reported electrical transformers less than 10 m from their home was 21.6%, while 42% reported high-voltage power lines less than 100 m from home. Finally, 40% of residents reported a TV transmitter within a radius of around 4 km.
The questionnaire included a statement that its purpose was health research and that the data gathered would be confidential.
Some 215 questionnaires were randomly distributed through 17 streets representing practically the entire village. The houses were selected using a street map of the village. In total, 150 questionnaires were collected with the remainder being uncollected because nobody was at home (31) or there was a refusal by the householder to complete the questionnaire (34).
During 2001, 101 RF EMF measurements in bedrooms were made. The other (49) residents who refused admittance for taking the measurements (16) were not at home for the scheduled measurement appointment (10) or had serious health problems (23).
However, some changes are now being introduced in this reanalysis. Thirteen of the participants included in the original study have now been eliminated: 2 participants were eliminated (one regarding alcohol abuse and another regarding pregnancy) to increase the requirement on health criteria and 11 participants were eliminated to increase the homogeneity of the RF EMFs measurements because there was a change (it was raining) in the usual dry weather conditions when the respective broadband measurements were registered.
The reanalysis of the dataset, which is the main focus of this paper, was finally performed with 88 participants (45 women and 43 men) instead of the 101 analysed in 2001.
Concerns about microwave exposure
Sixty-six of the 88 participants were reached by telephone in February 2012 and asked two questions:
Were you worried about the masts (BSs) when they were erected?
Did you believe their radiation (BSs) could damage your health?
In all cases, those who were worried about the masts were concerned about health consequences. Twenty-seven participants (40.9%) responded ‘no’ and 39 (59.1%) responded ‘yes’. Responses were analysed relative to age (analysis of variance (ANOVA) test), sex (λ statistic) and subjective distance to BS (Somers’ D statistic).
Broadband measurements were made on two Saturdays in February and March 2001 from 11:00 to 19:00 with a portable electrical field (400 MHz–3 GHz) detector (Nuova Elettronica Model LX-1435). This meter was calibrated with an HP-8510C network analyser inside an anechoic chamber at the University of Valencia. During the bedroom exposure assessment, the electric field probe was held for approximately 5 min about 1 m from the walls and 1.2 m above the ground—and moved around a circle of 0.25 m radius, orientating the antenna in different directions to obtain the maximum electrical field strength above the bed.
To check the intensity of TV and radio channels, as well as the intensity of working channels and broadcast channels for the GSM-900-1800 BSs, measurements of the spectral power density were carried out with a probe antenna and a portable spectrum analyser.
The probe was mounted on a linen phenolic tripod 1.2 m above the ground. The position of the probe was the same on both days—on a hill next to the village and 20 m from the BS. With the spectrum analyser we scanned the frequency bands and the levels were averaged for 6 min. The measurement of the spectrum was similar on both days—with a difference in the peak estimation (channel carriers) of about 1 dB.
The measured broadband exposure was almost invariable during the time interval of the measurements. Exposure changed with the position or place but it did not change over time, and this could be related with a low intensity of traffic (few phone calls) and the high and constant intensity of the broadcast channel.10
Demographic data were analysed using the Mann-Whitney one-way ANOVA and χ2 test. Differences between groups were performed through variance (ANOVA) and covariance analysis.
The main statistical analysis was made using binary logistic regression (mode enter) carried out on a regular basis with subsequent bootstrapping (1000 bootstrap replications, 95% percentile method and simple sampling)31 to provide more accurate SE and CIs. After producing (1000) bootstrap replicates θb of an estimator θ, the bootstrap SE was the SD of the bootstrap replicates.
where θ is the mean of the θb. Owing to our small sample size, a non-parametric CI for the estimate (mean) was constructed from the quartiles of the bootstrap sampling distribution of θ. The 95% percentile interval (θ (lower) <θ<θ (upper)) is shown, where θb are the r-ordered bootstrap replicates: lower=0.025×r (sample 25) and upper=0.975×r (sample 975).
The dependent variables (health-related symptoms) given in four ordinal categories (0=never, 1=sometimes, 2=often and 3=very often) were dichotomised (0, 1=0 vs 2, 3=1).
The 15 health-related symptoms described above constituted the dichotomous dependent variables. Univariate analysis was then performed for each symptom and for each of the predictor variables: exposure to BS (μW/m2 as a natural logarithmic) and age were used as continuous variables, while gender, computer use >2 h/day, mobile phone use >20 min/day and worry about the antennae were used as dichotomous variables. The covariates with predictive value were considered for the multivariate analysis. Thus possible confounder effects were evaluated.
In all cases, changes in –2 log likelihood, OR, 95% CIs and the p value were calculated. For all tests, a p value below 0.05 was considered statistically significant.
We used the GSM exposure (the measurement of RF EMF in the bedroom) as a continuous variable because it is recognised that categorisation of continuous variables introduces major problems in the analysis and interpretation of models derived in a data-dependent fashion.32–34
We chose exposure values in the logarithmic form because these values are well grouped around their median, while the raw values showed a high dispersion of values, with 2 outliers and 10 extreme values (data not shown).
Confounding was assessed by adding the potentially confounding variable to the model and making a subjective decision as to whether or not the coefficient of the variable of interest, ORs of GSM exposure, had changed substantially. A 10% variation was accepted as a considerable change.
Possible interactions between covariates were also evaluated.
The maximum number of covariates included in each multivariate analysis was calculated following this formula.35 Let π be the smallest of the proportions of negative or positive cases in the population and k the number of covariates, then the minimum number of cases to include is:
Goodness-of-fit tests such as the classification table, the Hosmer-Lemeshow statistic, receiver operating characteristic (ROC) curves, Cox and Snell's and Nagelkerke's Pseudo R2 measures were used. The Wald statistic was also evaluated to test the significance of individual independent variables. Moreover, possible multicollinearity was also tested.
With the predicted probability scores derived from the regression analysis, ROC curves were constructed for all symptoms or modalities in order to analyse sensitivity and specificity levels. For each curve, the best cut-offs for GSM exposure that maximises (sensitivity+specificity) were also calculated.
For statistical analysis, we used the Statistical Package for Social Sciences, V.21.0 (IBM SPSS Inc, Chicago, Illinois, USA) for Windows.
Owing to an exposure assessment for transformers, high-voltage power lines and radio or TV transmitters based on self-estimated distances would not produce a reliable exposure estimate, it was decided to omit these covariates in the analysis.
Demographic data and the percentage of users of personal computers and mobile phones were analysed. The mean age was 42 and 17 years (SD±17. 61, interval 15–81). Women totalled 51.1% (mean age=45.08 years, SD=17.98; interval=15–81) and 48.9% were men (mean age = 39.12 years, SD=16.88; interval=15–75). A total of 13.6% participants regularly used computers and 23.9% used mobile phones.
No differences related with age and use of mobile phones or computers were found between the sexes.
The univariate logistic regression indicated that age was inversely associated with irritability (OR=0.97, 95% CI 0.95 to 0.99) and that the oldest had the greatest difficulties hearing (OR=1.03, 95% CI 1.01 to 1.06) and walking (OR=1.04, 95% CI 1.01 to 1.07). However, gender clearly did not influence the outcome of any dependent variable. Use of mobile phones was linked with lack of appetite and vertigo, while worry about the radiation from BSs was associated with trouble sleeping (table 1). However, concern about radiation from BSs was unrelated to age (ANOVA test), sex (λ statistic) or subjective distance to BS (Somers’ D statistic).
Most of the symptoms were related with GSM exposure, especially fatigue, irritability, lack of appetite, trouble sleeping, depression and lack of concentration. Change in –2 log likelihood showed similar results (table 2). Figure 1 shows the distribution of EMF measurements throughout the sample.
ROC curves for each of the logistic regression models (GSM exposure vs each symptom) oscillated between 0.65 and 0.87 (table 3). Headaches (0.84), nausea (0.86), appetite (0.87) and vascular problems (0.85) showed the highest values, while memory (0.67), skin (0.67) and visual disturbances (0.65) showed the lowest values. The Hosmer and Lemeshow test indicated that most analyses showed no significant p values. The exceptions were fatigue (0.003), depression (0.003) and vertigo (0.03). In the majority of the cases, the models predicted better specificity than sensitivity. Only in the case of headaches and sleep disorder, did sensitivity prevail over specificity (table 3—classification table). In the extreme case, skin and vascular problems showed null or minimum sensitivity and 100% specificity. Nagelkerke pseudo R2 showed acceptable coefficients with the exception of the symptoms related with vertigo and skin problems (table 3).
Threshold cut-off values of GSM for sleep, attention, irritability and memory are also shown (table 3). The remaining cut-off values were not considered since sensitivity or specificity was reported at below 0.50%.
The influence of other covariates on the GSM ORs coefficients, such as age, cellular use and concern about the BS, was always less than 10% (table 2).
There was no observed multicollinearity among variables. The κ values according to factor analysis were always lower than 2 and well below the critical value of 30.
Finally, no interactions between covariates were observed.
SEs and CIs obtained by resampling were similar to those calculated from the asymptotic approximation (table 4). There was a small bias or difference between the average bootstrap coefficients (not shown) and the respective estimates obtained from the original sample.
There were no global health differences between those who permitted a bedroom exposure measurement (88 in our previous model) and those who refused RF measurements (26), and these results were unaltered when using age as a covariate. Square partial eta measured a 0% contribution of the willing participation variable to symptoms, such as irritability, headaches, walking difficulties and hearing loss that correlated with age. There was no relationship between subjective distance to the BS and willingness to participate (Pearson χ²=2.80, df=1; p=0.094).
However, ANOVA showed that the group with recorded RF EMF levels was more prone to symptoms of memory loss (F=5.07; p=0.027), while participants without EMF measures showed more skin problems (F=10.66; p=0.001).
In the present reanalysis, a more robust statistical method was employed that was indifferent to the assumption of normality. To reduce the limitation of the sample size effect and extrapolate our results to the entire population from which the sample was obtained, a resample method or bootstrapping was used.
This new study partially confirms our preliminary results—namely, that most of the symptoms are related to GSM levels independent of the demographical variables and some possible risk factors. Related to microwave radiation, the spectral power density analysis maintained that the most important contribution to broadband measurements was from GSM 900/1800, and the main variability of the measurements between different places was due to a different coverage of the GSM 900/1800 signals, that is, spatial variability. This was further supported by the fact that the antenna used was fairly insensitive to frequencies below 400 MHz. Therefore, the radio channels 80–110 MHz were not a significant part of the broadband measurements. Moreover, the narrow band measurements showed TV channels with substantially lower intensities than the GSM 900/1800 signals. The effects from these exposures will therefore not confound the effects of BSs. Moreover, some authors13 found that the only relevant contribution to the variance of the high microwave exposure was from BSs—up to 93% of variance. Moreover, at the time of our study, the GSM signal was almost invariable in time because there were very few calls. The main contribution was made from the broadcast channels working almost constantly throughout the day. Short-range evaluations of exposure could be acceptable for describing a 24 h period and the measurements were made in bedrooms—a location where the participants were assumed to spend significant periods of time.
However, some participants were mobile phone users at the time of this study and exposure to a mobile phone during a phone call is much higher than that received from BSs. Nevertheless, some authors13 stated about that there is no a priori argument why these lower levels should have no effect on the presence of a widespread use of mobile telephones. Exposure to a BS will be at a low but almost constant level for many hours of the day and especially at night.
While GSM exposure was associated with most of the symptoms, walking difficulties and hearing loss were correlated only with age. Age also remained slightly inversely associated with irritability. Users of cellular phones were more prone to symptoms of loss of appetite and vertigo, while those who expressed worry about the BSs were associated with sleep problems. This later finding was in concordance with two other articles.13 ,20 ,26 However, worry about the BSs was unrelated with age, gender or subjective distance to BSs. This agrees with an article36 claiming that there was no statistically significant association between symptom occurrence associated with perceived proximity to BSs, psychological components, sociodemographic characteristics and distance to BSs or power lines.
Some authors indicated that opponents of mobile phone towers generally do not express anxieties about EMF exposure, indicating that the risk rating is comparable with other commonly perceived hazards in the modern world.37
None of the analysed covariates behaved as confounders. The relationship of GSM exposure with irritability, sleep troubles, lack of appetite and vertigo remained statistically significant despite the introduction of the above covariates.
When the conventional multivariate analysis was tested using bootstrapping it was observed that the SE and CIs obtained by resampling were similar to those calculated from asymptotic approximation and this supports the adequacy of our conventional analysis. Our sample, chosen at random, represents the population from which it came.
The model appeared generally well adjusted while the cut-off values could constitute good guidance for predicting the threshold of symptom appearance.
We cannot truly state that residents were more worried, equally worried or less worried than elsewhere in this region, since we cannot provide the percentage of those worried about the BS masts in La Ñora compared with other nearby places. However, information about this issue was widespread in this region at the time, and the circumstances at La Ñora were shared with most other small urban and rural areas. The sample was randomly selected but a participation bias cannot be ruled out since most of our participants expressed fear regarding BSs and this could contribute to their participation in the study. It is also possible to speculate that the percentage of participants who refused to participate did so for the opposite reasons (indifference about BSs). In this regard, neither health status nor subjective distance to the BS explained a willingness to participate in the study.
Concerns about radiation from BSs were not related to age, sex or subjective distance to BSs. This agrees with statements from several authors13 that living near a BS does not make people generally fearful, but people who generally worry about fields express stronger fears when they live close to a station.
Nevertheless, irrespective of these explanations, there seems to be effects of exposure that occur independently of the fear felt by the participants, since controlling for fear did not change the association between exposure and symptoms. However, the late query about concerns (as a possible confounder) may render the results less valid. In contrast to our findings, note that biological grounds explaining non-thermal effects have not been clearly established. Recently, it has been stated that voltage-gated calcium channels are essential to the beneficial or adverse responses to microwave EMFs, nanosecond EMF pulses and static electrical and magnetic fields.38
In summary, the results of this study indicate that effects of very low but long-lasting exposure to emissions from mobile telephone BSs on well-being cannot be ruled out. The effects almost completely matched the symptoms described within the microwave syndrome. Finally, unravelling the causal pathways would be best performed with an experimental study design.
This new study partially confirms our preliminary results about microwave sickness resulting from exposure to emissions from GSM mobile phone BSs. Fatigue, irritability, lack of appetite, sleep troubles, depression and lack of concentration were especially related with GSM exposure.
These results were independent of the main sociodemographic variables, other EMF exposures and anxiety about being irradiated. Nevertheless, we confirm that apprehension about modern technology could predict some symptoms, especially those related with sleep problems.
Our results agree with those who claimed that by distorting perceptions of risk, disproportionate precaution might paradoxically lead to illness that would not otherwise occur.39 However, health changes related with GSM exposure seem to occur in a manner unrelated with those fears. Finally, exposure was very low during the period and also very low in comparison with Spanish recommendations40 and international guidelines.41
We subscribe to the guidelines observed by other authors42 in following the principle of prevention while the non-thermal effects are not considered in any official standard. This includes exposure minimisation within the limits of technical feasibility to guarantee a significant reduction in long-term radiation exposure to cellular phone towers in residential areas. Epidemiological and clinical studies should continue to observe possible health changes in the population. Finally, clear information about the correct use of newer electronic devices should be implemented.
The authors would like to express their gratitude to Angeles Martinez Gomez for her assistance during the fieldwork in La Ñora as well as to the Spanish Ministry of Science and Technology.
Contributors CG-P was mainly responsible for designing and writing the manuscript and also made the main statistical contribution. EAN was one of the researchers responsible for the design and acquisition of radiofrequency electromagnetic field (RF EMF) data, as well as writing and reviewing the manuscript. JS contributed mainly in processing the RF EMF data, while MP was responsible for the design and final review of the manuscript.
Funding This work was funded by the Spanish Ministry of Science and Technology for grant FIT number 070000-2002-58.
Competing interests None.
Patient consent Obtained.
Ethics approval Ethical Committee of the University of Valencia in accordance with the Declaration of Helsinki (http://www.wma.net/e/policy/b3.htm).
Provenance and peer review Not commissioned; externally peer reviewed.
Data sharing statement The data used in this statistical analysis can be obtained from Dr CG-P on request by email (firstname.lastname@example.org).