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Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort study from the Swedish National Diabetes Register
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  • Published on:
    More Data is Needed to Prove the Safety of Metformin
    • Fang LIU, Nephrologist
    • Other Contributors:
      • Yanhuan FENG, Ping FU, Yujie LIAO

    Dear Editor, Metformin is the most widely used hypoglycemic agent in the world. But the application among the diabetic patients who have the chronic kidney disease(CKD) is still controversial. What gave us a pleasant surprise was the observational study written by Ekstrom et al found that there were no increased risks of acidosis/serious infection in patients with renal impairment according to the large numbers of patient...

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    Conflict of Interest:
    None declared.
  • Published on:
    Metformin is a safe medication in mild-to-moderate chronic kidney disease.
    • David Arroyo, Nephrologist
    • Other Contributors:
      • David Arroyo, Soledad Garcia de Vinuesa, and Jose Luno

    Dear Editor,

    Ekstrom and colleagues publish a very interesting observational study comparing the rates of various outcomes depending on the type of antidiabetic drug prescribed.(1) This large population-based study presents some limitations, such as baseline difference between groups, attributing outcomes to initial treatment regardless of changes over time, or grouping diverse outcomes such as acidosis and infec...

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    Conflict of Interest:
    None declared.