You are here

Article Text

Article menu

Download PDFPDF

XML
Anaesthesia
Research
Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring
  1. Robert Rodrigues Pereira1,2,3,
  2. Humphrey Kanhai4,
  3. Frits Rosendaal5,
  4. Paula van Dommelen6,
  5. Dick Swaab7,
  6. Erik Rodrigues Pereira8,
  7. Ben van de Wetering9
  1. 1Department of Paediatrics, Maasstadziekenhuis, Rotterdam, the Netherlands
  2. 2Bouman Mental Health Care, Rotterdam, the Netherlands
  3. 3Department of Prevention and Care Netherlands Institute of Applied Sciences TNO, Leiden, the Netherlands
  4. 4Department of Obstetrics, Leiden University Medical Center, Leiden, the Netherlands
  5. 5Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands
  6. 6Department of statistics, Netherlands Institute of Applied Sciences TNO, Leiden, the Netherlands
  7. 7Netherlands Institute for Neuroscience, an Institute of the KNAW, Amsterdam, the Netherlands
  8. 8Central Office for Motor Vehicle Driving Testing (CBR), Amsterdam, the Netherlands
  9. 9Bouman Mental Health Care, Rotterdam, the Netherlands
  1. Correspondence to Dr Robert Rodrigues Pereira; pereirar{at}maasstadziekenhuis.nl

Abstract

Objective To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring.

Design Analysis of data from a cohort study.

Setting Academic hospital in Leiden, the Netherlands.

Participants 133 cases and 164 control individuals, aged 18–20 years at follow-up.

Main outcome measure Incidence of substance use disorder or use of alcohol and tobacco.

Results The lifetime use of addictive substances in children exposed to intrapartum Pethidine analgesia was 45% of 133 children versus 48% of 164 not-exposed subjects (adjusted OR=0.79, 95% CI 0.48 to 1.29). Recent use of alcohol, tobacco and hard drugs showed no statistical difference either.

Conclusion Pethidine for labour pain medication appears not to be associated with substance misuse or smoking in later life.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.

https://doi.org/10.1136/bmjopen-2011-000719

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • To cite: Rodrigues Pereira R, Kanhai H, Rosendaal F, et al. Parenteral Pethidine for labour pain relief and substance use disorder: 20-year follow-up cohort study in offspring. BMJ Open 2012;2:e000719. doi:10.1136/bmjopen-2011-000719

    • Contributors All authors contributed to the following criteria: (1) substantial contribution to conception and design, acquisition of data or analysis and interpretation of data; (2) drafting the article or revising it critically for important intellectual content and (3) final approval of the version to be published.

    • Funding This research received no specific grant from any funding agency in public, commercial or not-for-profit sectors.

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval Ethics approval was provided by Medical Ethical Committee of the Leiden University Medical Center, the Netherlands.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Data sharing statement All data are uploaded to the Dryad data repository and available for any scientist.