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Does the effect of vitamin A supplements depend on vaccination status? An observational study from Guinea-Bissau
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  • Published on:
    Re:There is no need for further placebo-controlled trials
    • Ane B. Fisker, Post doc
    • Other Contributors:
      • Peter Aaby, Christine S. Benn

    We thank Mayo-Wilson and colleagues for their comments(1). They have used our paper on the effect of vitamin A campaigns on mortality(2) not to question the paper itself, but to repeat a previous discussion(3, 4) about whether new trials of vitamin A supplementation (VAS) are needed to optimise the vitamin A policy. This is clearly a very important discussion.

    We think that new trials are needed. We have found i...

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    Conflict of Interest:
    None declared.
  • Published on:
    There is no need for further placebo-controlled trials
    • Evan Mayo-Wilson, Senior Research Associate (1)
    • Other Contributors:
      • Aamer Imdad (2), Kurt Herzer (3), Zulfiqar A Bhutta (2)

    To the Editor:

    We concur with Fisker et al. that factors moderating and mediating the effect of vitamin A supplementation on mortality are not fully understood.[1] Further observational studies could elucidate this relationship. New trials might examine the impact of delivering vitamin A at different times of year or with different doses and frequencies; however, we disagree with Fisker et al. that further tri...

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    Conflict of Interest:
    None declared.