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Abstract
Objectives To investigate the association of diabetes with postoperative outcomes in patients undergoing primary total hip arthroplasty (THA).
Design Retrospective cohort study using data from the US National Inpatient Sample (NIS).
Setting Study cohort was hospitalisations for primary THA in the USA, identified from the 2016–2020 NIS.
Participants We identified 2 467 215 adults in the 2016–2020 NIS who underwent primary THA using International Classification of Diseases, 10th Revision codes. Primary THA hospitlizations were analysed as the overall group and also stratified by the underlying primary diagnosis for THA.
Outcome measures Outcome measures of interest were the length of hospital stay>the median, total hospital charges>the median, inpatient mortality, non-routine discharge, need for blood transfusion, prosthetic fracture, prosthetic dislocation and postprocedural infection, including periprosthetic joint infection, deep surgical site infection and postprocedural sepsis.
Results Among 2 467 215 patients who underwent primary THA, the mean age was 68.7 years, 58.3% were female, 85.7% were white, 61.7% had Medicare payer and 20.4% had a Deyo-Charlson index (adjusted to exclude diabetes mellitus) of 2 or higher. 416 850 (17%) patients had diabetes. In multivariable-adjusted logistic regression in the overall cohort, diabetes was associated with higher odds of a longer hospital stay (adjusted OR (aOR) 1.38; 95% CI 1.35 to 1.41), higher total charges (aOR 1.11; 95% CI 1.09 to 1.13), non-routine discharge (aOR 1.18; 95% CI 1.15 to 1.20), the need for blood transfusion (aOR 1.19; 95% CI 1.15 to 1.23), postprocedural infection (aOR 1.62; 95% CI 1.10 to 2.40) and periprosthetic joint infection (aOR 1.91; 95% CI 1.12 to 3.24). We noted a lack of some associations in the avascular necrosis and inflammatory arthritis cohorts (p>0.05).
Conclusion Diabetes was associated with increased healthcare utilisation, blood transfusion and postprocedural infection risk following primary THA. Optimisation of diabetes with preoperative medical management and/or institution of specific postoperative pathways may improve these outcomes. Larger studies are needed in avascular necrosis and inflammatory arthritis cohorts undergoing primary THA.
- DIABETES & ENDOCRINOLOGY
- EPIDEMIOLOGY
- RHEUMATOLOGY
Data availability statement
Data may be obtained from a third party and are not publicly available. The authors cannot provide the data used in the study. The NIS is published online by the Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilisation Project (HCUP) and is available for purchase at https://hcp-us.asrq.gov/.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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STRENGTHS AND LIMITATIONS OF THIS STUDY
Our study uses the most current National Inpatient Sample (NIS) data, which uses International Classification of Diseases, 10th Revision coding, offering the most accurate and comprehensive view of total hip arthroplasty (THA) hospitalisations across the USA, ensuring broad applicability and relevance of our findings.
The NIS does not have a present-on-admission indicator so we only included postoperative complications that were specifically listed as postprocedural or initial encounters, ensuring that we did not include preoperative existing conditions or old diagnoses as postoperative complications.
Our study stratifies by the underlying condition for THA, allowing for nuanced analysis of trends and outcomes within groups and within the overall US population.
This is an observational study and therefore none of the associations can be assumed to be causal, and all findings must be interpreted accordingly.
The NIS does not include federal military or Veteran’s hospitals so findings may not be applicable to these populations.
Introduction
Primary total hip arthroplasty (THA) is an effective surgical treatment for end-stage hip joint disease1; its utilisation is increasing.2 As the obesity epidemic continues and the US population ages, obesity-related chronic conditions such as diabetes mellitus are becoming more common. It is important to understand the impact of diabetes on THA outcomes. Studies have shown that comorbidities, such as diabetes, may increase the risk of adverse outcomes including infections, thromboembolism, fracture and death,3–5 given altered osteoblast and osteoclast function in people with diabetes.
Previous retrospective studies examined primary total knee arthroplasty (TKA) and primary THA outcomes in people with diabetes.6–8 Diabetes was associated with higher short-term complications after THA in some studies,7 8 but not in others.6 The relevance to current THA populations is limited since data were examined only up to 2005,6–8 some studies combined TKA and THA populations,6 8 and one study only examined California state data.7 In a systematic review of observational studies to 2011, diabetes was associated with increased risk of surgical site infections, based on 50 infections in people with diabetes undergoing THA.9 A recent 2023 American College of Rheumatology and American Academy of Hip and Knee Surgeons (AAHKS/ACR) guideline for optimal timing of elective THA indicated that THA may be conditionally delayed to improve glycaemic control in diabetes, to improve outcomes, but this was based on low-quality evidence.10 Given the evidence gap, we need updated robust analyses of representative data with large sample to examine this question. The glycaemic control in diabetes may be worse in people with associated conditions such as osteoarthritis or inflammatory arthritis,11–13 which might lead to an increased risk of postoperative complications by the underlying diagnosis of THA. In this study, we used the US National Inpatient Sample (NIS), a large, nationally representative database. We assessed the effect of diabetes on the healthcare utilisation and clinical outcomes of all-comers who underwent primary THA and compared the impact of diabetes on these outcomes, with the overall sample stratified by the underlying primary indication for primary THA.
Methods
Data source
We used data from the NIS published by the Agency for Healthcare Research and Quality Healthcare Cost and Utilisation Project (HCUP) from 2016 to 2020.14 The NIS is the largest all-payer inpatient database publicly available in the USA. It consists of over 7 million inpatient stays, a 20% stratified sample of all discharges from US hospitals from 49 states, representing 98% of the US population. The NIS contains information on all hospital stays, regardless of payer. Using sample weights, the NIS can be used to provide national estimates. For each discharge, International Classification of Diseases, 10th Revision (ICD-10) clinical modification (ICD-10-CM) codes and procedure coding system (ICD-10-PCS) codes are available.14 All authors who accessed the NIS data filled out the appropriate HCUP Data Use Agreements (DUA). We prepared our manuscript in accordance with the Equator Network’s The Strengthening the Reporting of Observational Studies in Epidemiology guidelines.
Study cohort
We identified primary THA in adults using the ICD-10-PCS codes for the primary procedure code including any of the following: 0SR9*, 0SRA*, 0SRB*, 0SRE*, 0SRR* and 0SRS*.15–17 We determined the underlying arthritis/joint disease condition using ICD-10-CM codes in the primary position. Diabetes was identified using ICD-10-CM codes in the secondary diagnosis position: E10*, E11* and E13*.18–20 We excluded patients with the following primary underlying diagnoses for primary THA that were unlikely to be correct: periprosthetic fracture around internal prosthetic joint (M97*); intraoperative and postoperative complications, not classified elsewhere (M96*); medical and surgical care, not elsewhere classified (T80–T88*); sepsis/infections (A40*, A41*, A69*) or orthopaedic aftercare (Z47*).
Study outcomes and covariates
Outcomes of interest were healthcare utilisation outcomes: length of hospital stay (LOS), total charges, discharge disposition, mortality and postoperative outcomes using the initial encounter with an ICD-10-CM codes for the following: blood transfusions, prosthetic dislocation, prosthetic fracture, postprocedural infections, periprosthetic joint infections (PJIs), deep surgical site infections and postprocedural sepsis (online supplemental table 1; see ICD-10 codes). Due to a lack of present-at-admission indicators in the NIS, we only included the ICD-10-CM codes for periprocedural or for an initial encounter for the listed postoperative outcomes to ensure that no chronic or preoperative occurrences of these complications were included. Most healthcare utilisation variables have been clearly defined by the NIS. The hospital length of stay (LOS) and total hospital charges were categorised by the cohort median, as previously.21–23 Inpatient mortality was defined as patients who died during hospitalisation, as per the NIS documentation.14 Discharge disposition was dichotomised to routine (i.e, to home) and non-routine discharge from the hospital.
Supplemental material
Statistical analyses
We used complex weighting procedures to produce nationally representative estimates in accordance with HCUP guidelines.14 We calculated the utilisation rates (%) of primary THA for adults with diabetes. We assessed time trends across diabetes prevalence among all primary THA across years using the Cochran Armitage test. Due to the COVID-19 pandemic and the associated decrease in primary THA in 2020, we used 2016–2019 for time-trend analyses. We assessed trends in outcomes in people with diabetes who underwent primary THA across these years, using χ2 tests on categorical data and Wilcoxon tests for continuous variables. We performed multivariable-adjusted regression analyses to examine the association of diabetes with healthcare utilisation and clinical outcomes after primary THA, adjusted for age, sex, race, expected primary payer, Deyo-Charlson Comorbidity Index score, median household income for ZIP code, elective versus non-elective admission, and hospital bed size, control/ownership, census region, and teaching status. The Deyo-Charlson Index is a weighted medical comorbidity index derived from administrative databases that is associated with important outcomes after hospitalisation.24 It includes myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, rheumatic disease, peptic ulcer disease, liver disease (mild), renal disease (mild to moderate), hemiplegia or paraplegia, any malignancy, liver disease (moderate to severe), renal disease (severe), HIV infection (no AIDS), metastatic solid tumour, AIDS, diabetes and diabetes with chronic complications. ICD-10 codes and weights used to represent severity for each condition followed previously published guidelines.25 We used a modified Deyo-Charlson index excluding diabetes and diabetes with chronic complications to avoid double-counting. We calculated ORs and 95% CIs. We considered all p values <0.05 as statistically significant. We used SPSS V.29 and R V.4.3.1 (Vienna, Austria) to perform these analyses.
Patient and public involvement
None.
Results
Cohort characteristics
Between 2016 and 2020, 2 467 215 patients underwent primary THA, of whom 416 850 (17%) patients had diabetes (table 1). The mean age of patients undergoing THA was 68.7 years, 58.3% were female, 85.7% were white, 61.7% had Medicare payer and 15% had a Deyo-Charlson index of two or higher (online supplemental table 2). The underlying diagnoses were hip osteoarthritis (OA; N=1 761 960; 71.4%), traumatic fracture (N=5 32 910; 21.6%), avascular necrosis (AVN; N=78 275; 3.2%) and inflammatory arthritis (IA; N=3520; 0.1%) (includes rheumatoid arthritis (RA), spondylarthritis, including ankylosing spondylitis and psoriatic arthritis), and other diagnoses (N=90 550; 3.7%; online supplemental table 2). The median LOS was 2 days and median total hospital charges were US$56 891. There were slight changes in outcomes over time in the overall cohort (online supplemental table 3).
Patient characteristics of patients undergoing primary THA 2016–2020, stratified by the presence of diabetes mellitus
Comparing to patients without diabetes, patients with diabetes were on average 2.5 years older (70.8 vs 68.3 years; table 1), a lower proportion was female (53.7% vs 59.2%), white (79.9% vs 86.9%) and had an underlying diagnosis of OA (64.8% vs 72.6%). The cohort with diabetes had a higher proportion of people with a modified Deyo-Charlson score ≥2 (23.7% vs 12.9%), and the cohort with diabetes a higher mean Deyo-Charlson comorbidities, and Medicare as the primary payer (70.3% vs 60.0%; table 1). Hospital characteristics were similar in both patients with and without diabetes, but a higher proportion of people with diabetes were hospitalised in the South region (38.5% vs 34.7%; online supplemental table 4).
The crude rate of outcomes was worse in the diabetes cohort, who had a longer median hospital stay (3 days vs 2 days), higher median hospital charges (US$60 006 vs US$56 279), and higher rates of non-routine discharge (73.5% vs 65.4%; table 2). The crude rates of blood transfusion and each prosthetic complication were numerically higher in diabetes versus non-diabetes cohort (table 2).
Unadjusted differences in outcomes in people with versus without diabetes mellitus
Time trend analysis
We noticed a slight, consistent increase in the proportion of patients with diabetes among the entire cohort who underwent primary THA between 2016 and 2020: 16.08% in 2016, 16.67% in 2017, 16.70% in 2018, 17.08% in 2019 and 18.46% in 2020, an absolute increase of 0.98% between 2016 and 2019, which was statistically significant (p<0.001; online supplemental table 5).
Between 2016 and 2019, among people with diabetes, the number of people with OA as an underlying diagnosis increased slightly, and as expected during the COVID-19 pandemic in 2020, it decreased in parallel to the overall number undergoing primary THA (figure 1; online supplemental table 5). The rates for IA, AVN, traumatic fracture and other diagnoses stayed stable across 2016–2020 (figure 1).
Time-trends in the underlying diagnosis of primary THA among people with diabetes mellitus. The number of total primary THA and those with underlying diagnosis of osteoarthritis decreased in 2020, as expected during the early phase of COVID-19 pandemic in 2020, among people with diabetes mellitus. All other underlying diagnoses for THA were stable in numbers across 2016–2020. THA, total hip arthroplasty.
Compared to those without diabetes, in patients with diabetes, we noticed significantly shorter median hospital LOS, 3 vs 2 days (−33.3; p<0.001), and lower rates of non-routine discharge, 76.7% vs 70.1% (−8.4%; p<0.001 and the need for blood transfusion, 7.1% vs 4.8% between 2016–2019 (−32.7%; p<0.001; table 3). We also noted significantly higher total hospital charges, US$56 561 vs US$60 143 (6.3% higher; p<0.001), and higher rates of prosthetic fracture, 0.7% vs 1.3% (90.2% higher; p<0.001) and postprocedural infection, 0.6% vs 1.1% (89.8% higher; p<0.001; table 3), respectively.
Time-trends in postprimary THA outcomes in people with diabetes mellitus from 2016 to 2020
All these trends were seen in the overall cohort, except that inpatient mortality decreased non-significantly in the DM cohort (0.5% vs 0.4%; −26.4%; p=0.06) and decreased significantly in the overall primary THA cohort (0.4% vs 0.3%; −26.6%; p<0.001; online supplemental table 3).
Multivariable-adjusted analysis
In multivariable-adjusted regression in the overall cohort, diabetes was associated with higher adjusted odds of a longer hospital stay, higher hospital charges, non-routine discharge, the need for blood transfusion, postprocedural infection and PJI (table 4; online supplemental figure 1).
Multivariable-adjusted association* of diabetes mellitus with postprimary THA outcomes from NIS 2016–2020, overall cohort
In the OA cohort, we replicated all significant associations from the overall cohort except for the increased risk of postprocedural infection and PJI (online supplemental table 6). The traumatic fracture cohort showed all the associations as noted in the total cohort except postprocedural infection, and PJI; interestingly, and only in this cohort, diabetes was associated with a decreased risk of prosthetic fracture and prosthetic dislocation. In the AVN cohort, diabetes was only associated with an increased risk of a longer hospital stay and non-routine discharge (online supplemental table 6). We noted no significant associations in the inflammatory arthritis cohort that had the smallest sample size of 3520 (online supplemental table 6). Sensitivity analysis that additionally adjusted for the underlying diagnosis of THA confirmed all findings (online supplemental table 7).
Discussion
We used contemporary nationally representative US data to examine outcomes in people with diabetes undergoing primary THA. We used an approach that allowed us to exclude historic/past complications. The 2023 ACR and AAHKS Clinical Practice Guideline for optimal timing of TJA for moderate to severe osteoarthritis recommends delaying surgery for candidates with poorly controlled diabetes as this patient population has increased risk of poor outcomes, including increased LOS, following TJA, but the recommendation was conditional and based on low quality evidence.10 26 Our study fills this important knowledge gap. To our knowledge, this is among the first studies to assess the impact of diabetes on primary THA outcomes in a nationally representative sample, stratified by the underlying diagnosis. The proposed mechanisms for these poor outcomes infections in patients with diabetes include intraoperative physiological stress for diabetes-induced complications, extended LOS10 27 and impaired wound healing resulting in increased incidence of surgical site infections.28
Previous studies that reported an association of diabetes with poor THA outcomes had several limitations in that they (1) were single-centre studies,29–32 (2) used non-nationally representative data sets7 or (3) used ICD-9 codes6 8 33–35 and most used non-recent data. Studies of postoperative complications that used ICD-9 codes are limited since ICD-9 codes do not allow differentiation between complications associated with the index hospitalisation versus pre-existing diagnoses and conditions in the US NIS. Our study limited analyses of postoperative complications to only those specified by an ICD-10-procedure code or those with ICD-10-diagnosis code for initial encounter, to avoid erroneously counting prior diagnoses and procedures as postindex primary THA complications. We also excluded primary THA cases with erroneous codes for primary underlying diagnosis of primary THA, such as periprosthetic fractures. Due to the limitations of previous analyses, and an increasing prevalence of diabetes with high rates of undiagnosed diabetes,36 37 updated analyses are needed. Our study has several significant findings of interest that warrant further discussion.
In a population-based Danish study, revision rate due to deep infection was higher in people with diabetes, with an OR of 1.45 (95% CI 1.00 to 2.09) and in those with diabetes with complications, 2.11 (95% CI 1.00 to 2.09) at maximum follow-up of 11 years.38 In a systematic review of observation studies to 2011, based on 50 infections in people with diabetes undergoing THA (two single-centre, retrospective studies, including 1967–1980 and 1997–2007 periods)32 39 and one population-based study from 1996 to 2005,38 diabetes was associated with increased risk of surgical site infections with an OR of 2.04 (95% CI 1.52, 2.76).9 In our study based on 3255 postprocedural infections in 2 467 215 hospitalisations for primary THA, diabetes was associated with 1.62 times odds of postprocedural infection (included PJI, deep SSI and postprocedural sepsis) and 1.91 times odds of PJI. Our study quantifies the infection risk associated with diabetes in a contemporaneous nationally representative primary THA population. It also confirms early findings from primarily single-centre studies with small sample sizes and extends it to a national sample of primary THA in the USA. Thus, our study adds to the growing evidence of this link and indicates that this should be incorporated into clinical decision-making. The 2023 ACR/AAHKS Clinical Practice Guidelines recommend that diabetes be well managed based on the clinician’s assessment and do not specify a particular threshold for glycaemic control.10 The guidelines acknowledge insufficient evidence in the literature to support specific measurement limits for glycaemic control.10
We found that diabetes was associated with a longer hospital stay (>2 days) and non-home discharge in the overall cohort with ORs of 1.38 and 1.18, respectively, and for each underlying diagnosis (OA, fracture, AVN), except for the IA cohort. Similar associations were noted for total hospital charges above the median. Diabetes was associated with an unadjusted 0.7-day longer hospital stay compared with those without diabetes, similar to a finding from the US National Surgical Quality Improvement Programme data findings of a difference of 0.3 days in THA.40 Diabetes is associated with delayed wound healing41 42 and increased risk of other medical comorbidities,43 44 which is a risk factor for major postoperative complications45—both can lead to increased LOS and non-home discharge postprimary THA.
We included all-comers with diabetes, that is, type 1 and type 2 diabetes mellitus, similar to previous studies.6 46 We used the following ICD-10 codes: E10*, type 1 diabetes mellitus, E11*, type 2 diabetes mellitus and E13*, Other specified diabetes mellitus. We combined these codes because of the similar pathophysiology for infection risk, wound healing and some of the other systemic effects of hyperglycaemia. Both type 1 and type 2 diabetes have similar risks of chronic inflammation, immune dysregulation and impaired glucose control, contributing to similar complications across both types.8 47
We found that diabetes was associated with increased blood transfusion risk, overall and in the OA and fracture cohorts. This adds to the current knowledge. This can be attributed to the association of diabetes with anaemia,48–51 slow wound healing41 42 and higher rates of postoperative anaemia52 due to potentially more intraoperative blood loss. The mechanisms of anaemia in people with diabetes are multifactorial that include renal insufficiency, low erythropoietin levels, nutritional deficiency, associated autoimmune diseases and iatrogenic causes (oral antidiabetic drugs, ACE inhibitors and ARBs).48 53 54 The anaemia associated with diabetes is responsive to treatment54; optimising nutritional deficiencies and erythropoietin levels prior to primary THA may reduce the effects of anaemia and the need for blood transfusion.
The lack of some overall diabetes–outcomes associations in the AVN and IA cohort indicates that the underlying diagnosis and pathophysiology likely impact the risk of diabetes-associated complications. The IA cohort was small, and the analysis was likely underpowered, despite including US national data. Future studies of large multination registry data across may be needed to address outcomes in these groups.
In our THA cohort, diabetes had a prevalence of 17%, similar to its prevalence in older adults (≥65 years) and in TKA populations,55 56 but higher than that reported in previous studies of THA.8 9 Increasing rates of diabetes in the US THA populations have been reported by Bolognesi et al6 and Marchant et al8 who used data from 1988 to 2003 and 1988 to 2005 NIS data, respectively. The prevalence of diabetes in THA cohort is twice its prevalence in the general population.56 Diabetes is associated with an increased risk of OA (most common underlying diagnosis of THA), AVN, RA and hip fractures,57–59 which partially explain the enriching of THA population for diabetes.
Our study has various strengths. We used the most up-to-date NIS data, which is a nationally representative sample of THA hospitalisations in the USA. We only included postoperative complications that were specifically listed as postprocedural or initial encounters. The NIS has no present-at-admission indicators, and secondary diagnosis listing is not limited to initial encounters only. Therefore, limiting postoperative complications to initial encounter diagnoses only was a critical step in preventing the inclusion of pre-existing conditions as complications. We included multiple cohorts by the underlying diagnoses and compared the outcomes among these, allowing additional insights.
Our study findings should be interpreted considering several limitations. The NIS is an observational database. Therefore, relationships cannot be deemed as causal, but rather only as an association. This is because observational data does not allow evidence to establish causality, as opposed to a randomised trial. Observational studies such as ours are unable to control for all potential confounding variables leaving the possibility of residual confounding. Results should be interpreted with caution. The NIS does not include federal military, or Veteran’s hospitals, which leads to a challenge with generalisability to these populations. The NIS treats each hospitalisation as separate, therefore, bilateral THA may be counted as unilateral. Since simultaneous bilateral THA is <1% of all THA cases, this bias is negligible. There may be variation in coding of conditions, especially for secondary diagnoses, which can lead to misclassification bias both for outcomes and for Deyo-Charlson comorbidity index. The NIS has no longitudinal data, limiting the study of long-term outcomes.
In conclusion, diabetes was an independent risk factor for clinical and healthcare utilisation outcomes after primary THA in a contemporary US cohort. Given the high prevalence of diabetes and the ongoing obesity epidemic, the impact is significant. Studies need to examine if preoperative optimisation of diabetes achieved in those undergoing elective primary THA can potentially reduce these risks and improve outcomes. Preoperative management of high-risk patients with diabetes and multicomorbid conditions may be least resource-intensive and most rewarding. Interventional trials are needed in patients with diabetes undergoing primary THA to test effectiveness of interventions to improve THA outcome.
Data availability statement
Data may be obtained from a third party and are not publicly available. The authors cannot provide the data used in the study. The NIS is published online by the Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilisation Project (HCUP) and is available for purchase at https://hcp-us.asrq.gov/.
Ethics statements
Patient consent for publication
Ethics approval
This study was approved by the Institutional Review Board at University of Alabama at Birmingham (X120207004). All patient data are deidentified and are reported according to the Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilisation Project (HCUP) guidelines.
Acknowledgments
This work was presented as an abstract at the 2023 ACR in San Diego, CA by JAS. See: SRC, KR, JAS. Diabetes Mellitus Impacts Primary Total Hip Arthroplasty Outcomes: A National Cohort Study [abstract]. Arthritis Rheumatol. 2023; 75 (suppl 9). (https://acrabstracts.org/abstract/diabetes-mellitus-impacts-primary-total-hip-arthroplasty-outcomes-a-national-cohort-study/https://acrabstracts.org/abstract/diabetes-mellitus-impacts-primary-total-hip-arthroplasty-outcomes-a-national-cohort-study/).
References
Supplementary materials
Supplementary Data
This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.
Footnotes
Contributors SRC, KR and JAS designed the study and developed study protocol. SRC accessed the data and performed the analyses. SRC and JAS wrote the first draft of the paper. All authors reviewed analyses, revised the manuscript, read and approved the final manuscript. SRC had full access to the data and is the guarantor for the study.
Funding The authors did not receive any specific grant for this work from funding agencies in the public, commercial or not-for-profit sectors. JAS is supported by research grants from the National Institutes of Arthritis, Musculoskeletal and Skin Diseases (NIAMS; P50 AR060772), Department of Veterans Affairs (1 I01 RX002745; I01 BX005996-01A2) and the Patient Centered Outcomes Research Institute (PCORI; SDM-2017C2-8224; CER-2020C1-19193). JAS is also supported by the resources and the use of facilities at the VA Medical Center at Birmingham, Alabama, USA.
Competing interests JAS has received consultant fees from ROMTech, Atheneum, Clearview healthcare partners, American College of Rheumatology, Yale, Hulio, Horizon Pharmaceuticals/DINORA, ANI/Exeltis, USA Inc., Frictionless Solutions, Schipher, Crealta/Horizon, Medisys, Fidia, PK Med, Two labs Inc., Adept Field Solutions, Clinical Care options, Putnam associates, Focus forward, Navigant consulting, Spherix, MedIQ, Jupiter Life Science, UBM LLC, Trio Health, Medscape, WebMD, and Practice Point communications; the National Institutes of Health; and the American College of Rheumatology. JAS has received institutional research support from Zimmer Biomet Holdings. JAS received food and beverage payments from Intuitive Surgical Inc./Philips Electronics North America. JAS owns stock options in Atai life sciences, kintara therapeutics, Intelligent Biosolutions, Acumen pharmaceutical, TPT Global Tech, Vaxart pharmaceuticals, Atyu biopharma, Adaptimmune Therapeutics, GeoVax Labs, Pieris Pharmaceuticals, Enzolytics Inc., Seres Therapeutics, Tonix Pharmaceuticals Holding Corp., and Charlotte’s Web Holdings, Inc. JAS previously owned stock options in Amarin, Viking and Moderna pharmaceuticals. JAS is on the speaker’s bureau of Simply Speaking. JAS was a member of the executive of Outcomes Measures in Rheumatology (OMERACT), an organization that develops outcome measures in rheumatology and receives arms-length funding from 8 companies. JAS serves on the FDA Arthritis Advisory Committee. JAS is the co-chair of the Veterans Affairs Rheumatology Field Advisory Board (FAB). JAS is the editor and the Director of the University of Alabama at Birmingham (UAB) Cochrane Musculoskeletal Group Satellite Center on Network Meta-analysis. JAS previously served as s a member of the following committees: member, the American College of Rheumatology's (ACR) Annual Meeting Planning Committee (AMPC) and Quality of Care Committees, the Chair of the ACR Meet-the-Professor, 21 Workshop and Study Group Subcommittee and the co-chair of the ACR Criteria and Response Criteria subcommittee. SC and KCR have no conflicts of interest.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.
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