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Abstract
Introduction The widespread application of extracorporeal membrane oxygenation (ECMO) has enhanced clinical outcomes for patients experiencing cardiac arrest. However, its effectiveness is still limited and falls short of the desired level. Therapeutic hypothermia, which maintains body temperatures between 32°C and 36°C in cardiac arrest patients treated with ECMO, has been proposed as a potential means of neuroprotection and increased survival rates. Nevertheless, it remains controversial, and its impact on patient complications has yet to be fully understood. Thus, this paper aims to update the protocol for a systematic review of patients treated with ECMO and therapeutic hypothermia, in order to explore its effects on survival and neurological function.
Method and analysis This protocol has been developed in compliance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols 2015. The following databases will be systematically searched: PubMed, Web of Science, Cochrane Library, Embase, Ovid, CNKI, Wanfang and China Biology Medicine Disc. The database search strategy will use a combination of subject terms and free-text keywords. The search will encompass articles from the inception of each database up to 15 June 2023. Inclusion criteria encompass randomised controlled trials, cohort studies, case–control studies and quasi-experimental studies. Two researchers will independently review articles and extract relevant data based on these criteria. Any disagreements will be resolved through discussion. Data analysis will be performed using Review Manager software.
Ethics and dissemination Since no patient data were collected in this study, ethical approval was not required. Research findings will be released in a peer-reviewed journal.
PROSPERO registration number CRD42023435353.
- cardiopulmonary resuscitation
- systematic review
- cardiology
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Footnotes
Contributors PC, HW, LG and MW conceptualised and designed the study and drafted the manuscript. PC registered the review on the website of PROSPERO. HW developed the search criteria with input from LG and MW. HX, PG and JW contributed to the design of the statistical methods. PC wrote the original draft of the manuscript. MY critically revised all study contents and ideas. All authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript. The authors agree to take responsibility for the work.
Funding This work was supported by the Zhejiang Provincial Medical and Health Technology Project (Grant no. 2024KY1065).
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.
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