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Mental health
Original research
Anxiety and stress among healthcare professionals during COVID-19 in Ethiopia: systematic review and meta-analysis
  1. Aragaw Asfaw Hasen1,
  2. Abubeker Alebachew Seid2,
  3. Ahmed Adem Mohammed2
  1. 1Department of Statistics, College of Natural and Computational Sciences, Samara University, Semera, Afar, Ethiopia
  2. 2Department of Nursing, College of Medicine and Health Sciences, Samara University, Semera, Afar, Ethiopia
  1. Correspondence to Aragaw Asfaw Hasen; aragawasfaw5{at}gmail.com

Abstract

Objective This study intended to assess the impact of COVID-19 pandemic on anxiety and stress among healthcare professionals in Ethiopia.

Design This study applied a design of systematic review and meta-analysis of observational studies.

Eligibility criteria and outcomes Observational studies examining anxiety and stress among healthcare professionals in Ethiopia following COVID-19 pandemic were considered. The primary outcomes were the prevalence of anxiety and stress and the secondary outcomes were factors associated to the prevalence of anxiety and stress.

Data extraction and synthesis Two authors extracted the data and performed quality assessment independently. The Newcastle-Ottawa Scale was used to evaluate the quality of eligible studies. Random-effect model with the inverse variance method was used to estimate the pooled effect size of the outcome variables with its 95% CI. Publication bias was checked by DOI plot and Luis Furuya Kanamori index. Stata V.14.0 (StataCorp) software was used for statistical analysis.

Results Thirteen studies were included. From eight studies the pooled prevalence of anxiety was 46% (95% CI 0.30% to 0.61%, τ2=0.0497, I2=99.07%, p<0.001). Nine studies reported about stress and the pooled prevalence was 51% (95% CI 0.41% to 0.62%, τ2=0.0253, I2=97.85%, p<0.001)). Age, sex, marital status, working department, history of contact with confirmed COVID-19 cases and profession were associated factors for high level of anxiety and stress.

Conclusions COVID-19 pandemic highly affects mental health of healthcare professionals in Ethiopia. Anxiety and stress were among reported mental health problems among healthcare professionals during the pandemic. Timely psychological counselling programmes should be applied for healthcare professionals to improve the general mental health problems.

PROSPERO registration number CRD42022314865.

  • COVID-19
  • anxiety disorders
  • mental health
  • public health

Data availability statement

All data relevant to the study are included in the article or uploaded as online supplemental information.

http://creativecommons.org/licenses/by-nc/4.0/

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

https://doi.org/10.1136/bmjopen-2022-070367

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    STRENGTHS AND LIMITATIONS OF THIS STUDY

    • Screening, data extraction and quality assessment were done by two authors independently.

    • Newcastle-Ottawa Scale used to assess the risk of bias of the included studies.

    • Lack of sufficient studies on the impact of COVID-19 on anxiety and stress of healthcare professionals in Ethiopia.

    • Sensitivity analysis was not assessed due to no influential study was observed in the DOI plot.

    Introduction

    The COVID-19 pandemic, caused by SARS CoV-2, was first noted by authorities in Wuhan City, China, in December 2019.1 The fight against COVID-19 primarily being led by health professionals. They have a lot of clinical responsibility in the healthcare settings, which makes them extremely susceptible to this disease. Studies have begun examining the mental health problems related to the COVID-19 epidemic. For instance, a research on the COVID-19 pandemic’s effects on the mental health of Spanish healthcare workers (HCWs) revealed that the effects are more severe for HCWs than for non HCWs.2 As a result of the COVID-19 outbreak, more than two-thirds, more than half and almost one-fifth of the nurses in Iran reported anxiety, depression and stress, respectively.2 3

    According to a Chinese study, COVID-19 affected HCWs more psychologically than the overall population.4 Compared with the general population, HCWs were in higher risk perception, level of worry and knowledge related to COVID-19 infection.5 Compared with those documented elsewhere, the prevalence of anxiety is significantly higher among HCWs working in Africa.6 According to the UNICEF situation report, Ethiopia has 96 169 confirmed cases of COVID-19 as of 31 October 2020, and as of that date, 1876 healthcare professionals had tested positive and 77 had passed away.7

    According to research conducted in Ethiopia, the prevalence of anxiety ranges from 26.8% to 64.7%.8–10 High levels of anxiety are correlated with being a female health worker,9 being married,8 lack of personnel protective equipments and age,8 9 having chronic illness8 10 and contact with COVID-19 patient.10

    Studies conducted during the pandemic revealed that the prevalence of stress among medical staff in Ethiopia varied from 31.4% to 78.3%.9–15 The following factors are linked to HCWs’ stress: age10 11 being employed by a hospital9 11 being female, being married, being nurse14 and history of chronic illness10 14 are factors associated with stress of HCWs. Moreover, the results of a global meta-analysis conducted during the pandemic revealed that anxiety and psychological distress were both prevalent 38.12% and 37.54%, respectively. These mental health problems during COVID-19 pandemic need timely credit and initiation of interventions.16 In low-income and middle-income countries such as Ethiopia, little or no attention is given to psychological well-being of healthcare profession during the COVID-19 pandemic.8–10 All the effort is to control the spread of the pandemic and reduce its economic, social and political impacts.

    COVID-19 aggravates the mental health problems of healthcare professionals in Ethiopia. In addition, study results in Ethiopia showed that the evidence on mental health problems during the COVID-19 pandemic has reported high prevalence with heterogeneous findings.8–15 Therefore, comprehensive understanding and a summary on the impact of COVID-19 on the mental health status of healthcare professionals in Ethiopia is a timely study. This study aims to address this gap by providing a systematic review and meta-analysis to estimate the pooled prevalence of anxiety and stress and their associated factors during the COVID-19 pandemic. The study also provides comprehensive evidence for researchers, practitioners and mental health intervention policy makers to focus on healthcare professional’s mental well-being during COVID-19 pandemic and future emergency situations.

    Objectives

    General objective

    • This study intended to assess the impact of COVID-19 on anxiety and stress among healthcare professionals in Ethiopia.

    Specific objectives

    • To calculate the pooled prevalence of anxiety and stress during COVID-19 pandemic among healthcare professionals in Ethiopia.

    • To provide the pooled effect size and summary for associated factors of anxiety and stress during COVID-19 pandemic among healthcare professionals in Ethiopia.

    To provide far-reaching evidence to focus on the mental well-being of healthcare professionals during COVID-19 pandemic and future emergency situations.

    Methods and analysis

    Protocol registration

    This study is conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement.17 The protocol was registered in the International Prospective Register of Systematic Reviews PROSPERO registration number: CRD42022314865. The PRISMA flow chart for reporting systematic review and meta-analysis is presented in figure 1.

    Figure 1
    Figure 1

    Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow chart.

    Search strategy

    Searching literature was conducted in PubMed, Cochrane Library, CrossRef and Google Scholar databases and articles published from the occurrence of the pademic to June 2022 were included. Observational studies that assess the mental health (anxiety and stress) impact of COVID-19 among healthcare professionals in Ethiopia were considered. Systematic searches were conducted by combining every possible combination of predefined search terms determined by Medical Subject Headings (MeSH) and keywords (online supplemental file 1). Reference lists of key full text articles included in the review were checked to recognise any potentially eligible studies. The systematic procedure substantiates that the literature search comprises all published studies on the impact of COVID-19 among healthcare professionals in Ethiopia. The search results were exported to Mendeley where duplicates were removed.

    Two authors (AAH and AAS) independently screened titles and abstracts of the studies, and any disagreement between the authors was resolved by consensus or by another third author (AAM). The search strategy of databases is presented in online supplemental file 1. The search strategy is considered as suitable to reduce the risk of selection and detection bias.

    Eligibility criteria

    Inclusion criteria

    For this study, only observational studies (cross-sectional studies) that investigated the influences of COVID-19 on the mental health (anxiety and stress) of healthcare professionals during the pandemic in Ethiopia were included.

    Setting/context

    Studies conducted in Ethiopia were the concern of this systematic review.

    Population

    This review included studies involving all groups of healthcare professionals.

    Study design

    Observational studies (cross-sectional studies) that reported the prevalence of anxiety and stress and their associated factors.

    Language

    Studies reported in English language were considered.

    Exclusion criteria

    The following types of studies were excluded:

    1. Studies that involved whole population.

    2. Studies that did not have enough statistical data to be extracted.

    3. Descriptive reviews, randomised controlled trials, systematic review, meta-analysis, editorials, comments, conference abstracts, opinions and studies not exactly reported the prevalence and associated factors of anxiety and stress of healthcare professionals were excluded.

    Outcome measures

    There were two main outcomes in this systematic review and meta-analysis. The primary outcomes were the pooled prevalence of anxiety and stress among healthcare professionals during the COVID-19 pandemic. The secondary outcomes of the study were the pooled effect size of associated factors related to the prevalence of anxiety and stress among healthcare professionals during the COVID-19 pandemic in Ethiopia.

    Selection of studies

    Two authors (AAH and AAS) assessed the studies based on inclusion and exclusion criteria. First, the authors assessed both the titles and abstracts of the studies identified from the searched databases. Then, full-text screening was done to screen the full texts selected in the previous stage. Moreover, we have a rationale for inclusion and exclusion of studies in the PRISMA flow diagram. Finally, the final list of articles for data extraction for systematic review and meta-analysis was prepared for the analysis.

    Data extraction

    The data extraction was done by two reviewers independently. There was pretest the data extraction form on three pilot surveyed studies, to ensure effective, facilitates the collection of all necessary data required for the valuable systematic review and meta-analysis. Disagreements were resolved by deep discussion. For the incorporated studies, we extracted the author’s last name, year of publication, where the study was conducted (region), study design, cases, sample size, sampling design, study population, outcome measures and main findings.

    Methodological quality assessment

    Two authors (AAH and AAS) autonomously assessed the quality of the included studies by the Newcastle-Ottawa Scale (NOS).18 The scale rates observational studies based on three parameters named selection, comparability and assessment of exposure/outcome. Studies with less than 5 scores were considered low quality, 5–7 scores of moderate quality and more than 7 scores of high quality.19 Studies with moderate and above quality score were considered for this systematic review and meta-analysis.

    Data synthesis

    The extracted data were entered in to Microsoft Excel and then imported to Stata V.14.0 (StataCorp) software to conduct the meta-analysis. We calculated pooled prevalence and pooled adjusted OR with 95% CI and predictive interval (PI) by using random-effect model with the generic inverse variance method. Assessment of heterogeneity was checked by τ2,20 I2 and Cochran’s Q-statistics.21 22 To decide the source of heterogeneity subgroup analyses was performed by regions and instruments used in individual studies. Publication bias was checked by DOI plot and Luis Furuya Kanamori (LFK) index as the number of studies used was small. The DOI plot and the LFK index tools were used to determine the effect (ie, publication bias) and asymmetry of studies with small sample size.23 24 A value outside the interval −1 and 1 were considered consistent with asymmetry (ie, publication bias) according to the LFK index.24

    Patient and public involvement

    No patient and public involvement.

    Results

    A PRISMA diagram illustrating the steps of database search and refining process for the study on mental health problems of healthcare professionals during the COVID-19 pandemic period was depicted in figure 1. From our databases search, initially 30 studies were identified. Eight duplicates were removed and we inspected the titles and abstracts then five studies were removed. Seventeen full text studies were examined and four studies were removed by reasons that did not met inclusion criteria. Finally, we recognised 13 studies appropriate to this systematic review and meta-analysis.

    Study characteristics

    In this systematic review and meta-analysis, we included 13 cross sectional studies8–15 25–29 focused on the impact of COVID-19 on anxiety and stress status among healthcare professionals during COVID-19 in Ethiopia. When we observe the regional distribution, four studies9 12 15 27 were from SNNP, three studies11 13 26 were from Oromiya, three studies8 10 14 were from Amhara, one study28 was from Addis Ababa and Oromiya, one study29 was from Addis Ababa and one study25 was in all regions (national level). Depending on the types of mental disorders, eight studies8–10 12 25 26 28 29 were reported about anxiety and nine studies9–11 13–15 26–28 were reported about stress. Moreover, the summarised data of the key characteristics of the included studies are showed in table 1.

    View this table:
    Table 1

    Key characteristics and quality of the included studies for anxiety and stress on HCWs during the COVID-19 pandemic in Ethiopia

    Quality of included studies

    A quality score of the 13 included studies using the modified NOS for cross-sectional studies quality assessment was presented in table 1. Thus, four studies were regarded as moderate quality10 11 13 25 and nine studies were high quality8 9 12 14 15 26–29 were considered for final systematic review and meta analysis.

    Publication bias

    Publication bias was assessed by the DOI plot,23 a tool used to visualise asymmetry and by the LFK index,24 a tool used to detect and quantify asymmetry of study effects. As shown in figure 2, no publication bias was observed. There is no asymmetry for anxiety studies (LFK index=0.75) and for stress studies (LFK index=−0.05). In both cases the, LFK index was between the interval (−1, 1), this supports there is no publication bias.24

    Figure 2
    Figure 2

    DOI plot for assessment of publication bias.23 LFK, Luis Furuya Kanamori.

    Meta analysis on prevalence of mental disorders

    Pooled prevalence of stress

    From a total of 9 studies, the pooled prevalence of stress was 51% (95% CI 0.41% to 0.62%, τ2=0.0253, I2=97.85%, p<0.001) as shown in the forest plot figure 3. The significant variability of study results has been observed since I2=97.85% and τ2=0.0253.

    Figure 3
    Figure 3

    A forest plot for the prevalence of stress among the healthcare professionals during the COVID-19 pandemic. The pooled prevalence of stress. Note: Weights are from random-effects model. ES, effect size; Weight, weight of each included study.

    Subgroup analysis of stress by region

    To explore the source of variability in studies subgroup analysis was done by region. From the forest plot in figure 4, the pooled prevalence of stress in SNNP, Addis Ababa and Oromiya, Oromiya and Amhara was 48%, 34%, 59% and 53%, respectively. The prevalence was higher in Oromiya region compared with the others. The heterogeneity test result (table 2) (Q=10.99, p<0.001) indicates that there was significant variability among regions.

    Figure 4
    Figure 4

    A subgroup analysis of prevalence of stress among healthcare workers during the COVID-19 pandemic by region. Note: Weights and between-subgroup heterogeneity test are from random-effects model. SNNP, Southern Nation Nationalities and People.

    View this table:
    Table 2

    Mental disorders and heterogeneity assessment among subgroups

    Subgroup analysis of stress by instrument

    From the subgroup analysis by instrument used forest plot in figure 5, the pooled prevalence of stress in 10-item Perceived Stress Scale, 21-item Depression Anxiety Stress Scale (DASS-21), Impact of Event Scale (Revised) and Kasseler-10 was 48%, 44%, 59% and 42%, respectively. From heterogeneity test among instruments results (table 2) (Q=21.97, p<0.001) implies that there was significant heterogeneity among measurements used in the studies. This might be due to the existence of differences in sensitivity and specificity of the assessment instruments used to screen out mental disorders among healthcare professionals during the pandemic.

    Figure 5
    Figure 5

    A subgroup analysis of prevalence of stress among healthcare workers during the COVID-19 pandemic by the instrument used. Note: Weights and between-subgroup heterogeneity test are from random-effects model. DASS-21, 21-item Depression Anxiety Stress Scale; IES-R, Impact of Event Scale-Revised; Kasseler-10, 10- item Kessler Psychological Distress Scale; PSS-10=10 item Perceived Stress Scale.

    Pooled prevalence of anxiety

    A total of 8 studies reported the prevalence of anxiety, and the pooled prevalence of the anxiety was found 46% (95% CI 0.30% to 0.61%, τ2=0.0497, I2=99.07%, p<0.001). As shown in figure 6, there exists significant heterogeneity among study findings on prevalence anxiety among healthcare professionals through the pandemic.

    Figure 6
    Figure 6

    A forest plot for the prevalence of anxiety among the healthcare professionals during the COVID-19 pandemic. The pooled prevalence of anxiety. Note: Weights are from random-effects model. ES, effect size; Weight, weight of each included study

    Subgroup analysis of pooled prevalence of anxiety by region

    From the subgroup analysis of prevalence of anxiety by region the pooled prevalence of anxiety in SNNP, Addis Ababa and Oromiya, Oromiya, all regions, Amhara and Addis Ababa was 36%, 78%, 31%, 27%, 64% and 31%, respectively (figure 7). The prevalence was higher in the Addis Ababa and Oromiya region compared with the others. There was significant heterogeneity among regions (Q=750.46, p<0.001) (table 2).

    Figure 7
    Figure 7

    A subgroup analysis of prevalence of anxiety among healthcare workers during the COVID-19 pandemic by region. Note: Weights and between-subgroup heterogeneity test are from random-effects model. SNNP, Southern Nation Nationalities and People.

    Subgroup analysis of anxiety by the instrument

    From the subgroup analysis by instrument used (figure 8) the pooled prevalence of anxiety in 7-item Generalised Anxiety Disorder scale (GAD-7) and DASS-21 was 37% and 74%, respectively. The heterogeneity test between group result (table 2) (Q=17.77, p<0.001) implies that the existence of significant heterogeneity between measurements (GAD-7 and DASS-21) used in the studies. This might be due to difference in sensitivity and specificity on the assessment instruments used.

    Figure 8
    Figure 8

    A subgroup analysis of prevalence of anxiety among healthcare professionals during the COVID-19 pandemic by instrument. Note: Weights and between-subgroup heterogeneity test are from random-effects model. DASS, 21-item Depression Anxiety Stress Scale; GAD-7, 7-item Generalised Anxiety Disorder scale.

    Pooled adjusted OR of associated factors of mental disorders

    As shown in table 3, we found sex is associated factor of anxiety of healthcare professionals during the COVID-19 pandemic. Accordingly, the odds of female HCWs were nearly 1.89 times more likely to develop anxiety than male HCWs (pooled AOR 1.89, 95% CI 1.41 to 2.37). The test statistics revealed that no heterogeneity among the included studies (τ2=0.00, I2=0.00% and p=1.000). The odds of HCWs working at COVID-19 isolation centre were three times more likely to develop anxiety than their counterparts (pooled AOR 3.02, 95% CI 1.67 to 4.37) and (τ2=0.00, I2=0.00% and p=0.634). The odds of HCWs contact with confirmed cases are two times more than who do not have contact (pooled AOR 1.98, 95% CI 1.04 to 2.92) and (τ2=0.00, I2=0.00% and p=0.857).

    View this table:
    Table 3

    Pooled adjusted OR (AOR) of associated factors of anxiety and stress among HCWs during the pandemic in Ethiopia

    When we see sex as a factor of stress, the odds of female HCWs were two times more likely to develop stress than male (pooled AOR 2.02, 95% CI 1.23 to 2.80). The test statistics revealed no heterogeneity among the included studies (τ2=0.00, I2=0.00% and p=0.825). Similarly, the odds of HCWs working at COVID-19 isolation centre were 2.38 times more to develop stress than pharmacy (pooled AOR 2.38, 95% CI 0.79 to 3.96) (τ2=0.00, I2=0.00% and p=0.634). The odds of HCWs younger in age are 2.5 times more to develop stress than their counterparts (pooled AOR 2.50, 95% CI 0.16 to 4.85). The test statistics revealed that no heterogeneity among the included studies (τ2=0.00, I2=0.00% and p=0.861). The odds of married HCWs were 2.8 times more to develop stress than single HCWs (pooled AOR 2.8, 95% CI 1.99 to 3.61) and (τ2=0.00, I2=0.00% and p=0.500). Profession has its own influence to develop stress. The odds of medical laboratory professional HCWs were 2.69 times more to develop stress than nurses (pooled AOR 2.69, 95% CI 1.45 to 4.93) and (τ2=2.3345, I2=89% and p=0.003) indicates that heterogeneity was observed between studies. Also we tried to explore significant factors associated with anxiety table 4 and stress table 5 systematically.

    View this table:
    Table 4

    A summarised reviews of significant associated factors of anxiety and their magnitude among healthcare professionals during the COVID-19 pandemic in Ethiopia

    View this table:
    Table 5

    A summarised reviews of significant associated factors of stress and their magnitude among healthcare professionals during the COVID-19 pandemic in Ethiopia

    Discussion

    Due to COVID-19 pandemic, healthcare professionals were with a variety of mental health problems. There are studies at the single level, but to our knowledge, this systematic review and meta-analysis was the first of its kind that assessed the pooled prevalence and associated factors in Ethiopia. In this systematic review and meta-analysis, the pooled magnitude and associated factors of anxiety and stress were assessed. The study includes 13 articles focusing on the impact of COVID-19 on mental health problems (anxiety and stress) of healthcare professionals in Ethiopia. We believed that all of the incorporated studies are conducted with the ethical guideline. The pooled prevalence of anxiety and stress, and their associated factors discussed as follows.

    The pooled prevalence of anxiety among the HCWs during the COVID-19 pandemic was 46%. This is higher compared with the recent meta-analysis results in Africa 37%,6 30 29%31 in China 27%32 in Kenya 36%33 and global study 34.4%.34 This is lower than study in Egypt 71.8%35 73.3%.36 This difference could be due to the difference on the awareness level of healthcare professionals regarding the potential transmission mechanisms. From the subgroup analysis by region the prevalence of anxiety in Addis Ababa and Oromiya 78% and Amhara region 64% is high compared with other regions. This could be due to the first case was reported in Addis Ababa. From subgroup analysis by instrument used, there is heterogeneity and the pooled prevalence of anxiety on study measured by DASS-21 is 74%. Also, the pooled prevalence by GAD-7 is 37%, this is lower than study by GAD-7 in Sudan 53.3%37 and South Africa 66.1%.38 This might be due to the sensitivity and specificity of the instruments.

    The pooled adjusted OR of female HCWs is 1.89, 95% CI (1.41 to 2.37) implies that the odds of female HCWs 1.89 times more to develop the anxiety than males during the pandemic. This is supported by study in Kenya.33 So that female HCWs need more psychological support.39 Similarly, working at COVID-19 isolation centre adjusted OR is 3.02, 95% CI (1.67 to 4.37), meaning that the odds of healthcare professionals working at emergency/isolation centre three times more to develop anxiety than pharmacy. The pooled adjusted OR of HCWs contact with confirmed cases is 1.98, 95% CI (1.04 to 2.92) implies that the odds of HCWs contact with confirmed cases are nearly two times more than who do not have contact. This is in line with study in Kenya.40

    The pooled prevalence of stress among HCWs during the COVID-19 pandemic was 51%. This was higher than the prevalence of stress among older HCWs 40.3%34 and 42.1%32 in Chinese HCWs, lower than study in Egypt 66.6%.35 The subgroup analysis by region heterogeneity test indicates that there is significant variability among regions. The prevalence in Oromiya region is 59%, which is higher compared with the other regions. Also, subgroup analysis by instrument measuring stress indicates there is significant heterogeneity among instruments.

    The pooled adjusted OR on female HCWs is 2.02, 95% CI (1.23 to 2.80) implies that the odds of female HCWs are two times more to develop stress than males during the pandemic. This is supported by study in Kenya40 and study in South Africa.38 Working at COVID-19 isolation centre the pooled adjusted OR is 2.38, 95% CI (0.79 to 3.96) meaning that the odds of working at COVID-19 isolation centre 2.38 times more to develop stress than their counterparts. This is in line with study reported nurses work place leads to develop stress.41 Also, younger in age pooled adjusted OR is 2.50, 95% CI (0.16 to 4.85) implies that the odds of younger in age HCWs is 2.50 times more to develop stress than older. This is in line with study South Africa.38The odds of married HCWs were 2.8 times more to develop stress than single (pooled AOR 2.8, 95% CI 1.99, 3.61), this contradicts with study in South Africa reported married HCWs are less likely to develop stress.38 Profession has its own effect to develop stress. The odds of medical laboratory professional HCWs were 2.69 times more to develop stress than nurses (pooled AOR: 2.69, 95% CI 1.45 to 4.93). This is in line with a study on Mexican nurses stating presence of a confirmed and suspected case of COVID-19 in their workplace worse the mental health outcomes.42

    Whereas, this study is with strengths and limitation. Screening, data extraction and methodological quality assessment were performed by two authors independently. The quality of included studies was done by the NOS of the included studies. The absence of sufficient studies on the impact of COVID-19 on the mental health (anxiety and stress) of healthcare professionals in Ethiopia, and sensitivity analysis was not assessed due to no influential study is observed in the DOI plot were the limitation of this study.

    Conclusion

    The COVID-19 pandemic produced a variety of mental health impacts among healthcare professionals in Ethiopia. The prevalence of stress and anxiety among HCWs was significantly high in Ethiopia due to COVID-19 pandemic. There was heterogeneity on the prevalence of anxiety and stress on healthcare professionals among regions and instruments used. The timely establishing programmes that offer awareness on the COVID-19 virus, psychological counselling and intervention should be applied for HCWs to improve the general mental health problems. In addition, further studies on the long-term impacts of COVID-19 pandemic on mental health of healthcare professionals and on the general population should be investigated.

    Data availability statement

    All data relevant to the study are included in the article or uploaded as online supplemental information.

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    Footnotes

    • Contributors All authors have made significant contributions to this study. AAH developed the research question, wrote the first draft, designed the search strategy, edited and approved the final version of the article and controlled and managed the overall work. AAS revised the search strategy of databases, developed the data extraction form edited and approved the final version of the article. AAM revised the data extraction form and edited and approved the final version of the article.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; externally peer reviewed.

    • Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.