Article Text
Abstract
Objective To report and compare psychological distress as symptoms of anxiety, depression and post-traumatic stress among intensive care units’ (ICU) nurses, physicians and leaders at 12 months after the baseline survey (spring 2020), during the COVID-19 pandemic in Norway. Furthermore, to analyse which baseline demographic and COVID ICU-related factors have a significant impact on psychological distress at 12 months.
Design Prospective, longitudinal, observational cohort study.
Setting Nationwide, 27 of 28 hospitals with COVID ICUs in Norway.
Participants Nurses, physicians and their leaders. At 12 month follow-up 287 (59.3%) of 484 baseline participants responded.
Primary and secondary outcome measures Symptoms of anxiety and depression using the Hopkins Symptoms Checklist-10 (HSCL-10). Symptoms of post-traumatic stress using the post-traumatic stress disease checklist for the Diagnostic and Statistical Manual of Mental Disorders 5 (PCL-5).
Demographics (included previous symptoms of anxiety and depression) and COVID ICU-related factors (professional preparations, emotional experience and support) impacting distress at 12 months.
Results Psychological distress, defined as caseness on either or both HSCL-10 and PCL-5, did not change significantly and was present for 13.6% of the participants at baseline and 13.2% at 12 month follow-up. Nurses reported significantly higher levels of psychological distress than physicians and leaders. Adjusted for demographics and the COVID ICU-related factors at baseline, previous symptoms of depression and fear of infection were significantly associated with higher levels of anxiety and depression at 12 months. Previous symptoms of depression, fear of infection and feeling of loneliness was significantly associated with more symptoms of post-traumatic stress.
Conclusion One year into the COVID-19 pandemic 13.2% of the ICUs professionals reported psychological distress, more frequently among the nurses. Fear of infection, loneliness and previous symptoms of depression reported at baseline were associated with higher levels of distress. Protective equipment and peer support are recommended to mitigate distress.
Trial registration number ClinicalTrials.gov. Identifier: NCT04372056.
- Adult intensive & critical care
- COVID-19
- Physicians
- Nursing Care
- MENTAL HEALTH
Data availability statement
Data are available upon reasonable request. Because the respondents written informed consent data are not available upon request, we have provided an additional, non-author, point of contact that interested researchers can get in touch with to secure accuracy regarding our data.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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STRENGTHS AND LIMITATIONS OF THIS STUDY
National study of healthcare professionals working in 27 out of 28 COVID intensive care units.
12 month longitudinal cohort of 59% of baseline respondents.
Because of an incomplete national register, the response rate among all professionals is unknown.
Self-report checklists provide an estimate of psychological distress, but they are not comparable with a diagnostic interview in terms of accuracy.
Introduction
From the onset of the COVID-19 pandemic, nurses, physicians and their leaders (healthcare professionals) worked on the front lines in intensive care units (COVID ICUs). Healthcare professionals worldwide experienced increased workload, exposure to excess death, moral distress because of limited treatment options and capacity, and fear of infection because of insufficient protective equipment.1 Even before the pandemic, studies have found particular high levels of all types of psychological distress from moral distress and burnout to anxiety, depression and post-traumatic stress disorder (PTSD) among ICU healthcare professionals connected to the high frequency of demanding work-task like end-of-life decisions, critical ill patients and advanced treatment regimen.2 3 The pandemic posed a risk of further rising levels potentially leading to manifest illness and resignation. The first publication from China stated that 50% of all healthcare professionals reported symptoms of depression and 45% symptoms of anxiety.4 In Italy, which early on during the pandemic was severely affected, 25% of healthcare professionals reported symptoms of depression and 20% symptoms of anxiety, whereas 50% reported symptoms of post-traumatic stress.5 During the SARS epidemic, up to 40% still reported symptoms of post-traumatic stress up to 3 years after the end of the epidemic.6
A systematic review of healthcare professionals during the SARS epidemic concluded that both occupational factors and social factors influenced psychological distress.7 The occupational factors identified to increase psychological distress were low perceived preparedness, working in a high-risk environment, occupational role (nurse), lack of control at work, being quarantined and the fear of infection.7 On the other hand, social factors that increased distress were isolation or social rejection, whereas support, both at work and from family/friends, were protective factors.7
The COVID-19 pandemic imposed the need to perform a national survey on psychological distress among healthcare professionals working in COVID ICUs. To the best of our knowledge, this is the first national, longitudinal cohort study of healthcare professionals working in COVID ICUs. We have previously published results from the baseline national survey, performed in spring 2020, launched 10 weeks after the first confirmed case in Norway.8 9 The healthcare professionals reported low levels of anxiety, depression and post-traumatic stress compared with the first reports from China and Italy.4 5
The primary aim of the present paper is to report the symptoms of psychological distress as anxiety, depression and post-traumatic stress among the COVID ICU nurses, physicians and leaders at the 12 month follow-up and compare the symptom levels between the professions. Second, analyse which of the baseline demographic and COVID ICU-related factors: professional, emotional and/or supportive, were predictors of psychological distress at the 12 month follow-up.
Methods
Study design
This was a prospective, longitudinal, cohort study with two follow-up assessments of the same individual respondents. Data were collected at baseline, at 6 month follow-up and at 12 month follow-up. Data from questionnaires at baseline and 12 month are presented in this paper as there was no clinically significant changes in level of distress between baseline and 6 month and 6 month and 12 month. The methods and results are reported according to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) cohort checklist.10
Study setting, participants and inclusion process
The baseline data were collected during the period 6 May 2020 to 15 July 2020. The 12 month follow-up data were collected from 5 May 2021 to 6 June 2021. The inclusion criteria were having a Norwegian social security number, working in an ICU with COVID-19 patients and being either a nurse, physician or leader. The subgroups of the professions are described in the two publications of baseline data.8 9 The leaders included were the managers of the ICUs, with personnel responsibility for the nurses and physicians. The sample included 27 of the 28 hospitals with a COVID ICU in Norway. One hospital did not participate because of delays in the local approval process. The project leader distributed e-mails to all leaders of the COVID ICUs with information about the study and an invitation to participate; these leaders were then asked to forward the invitation to all relevant employees. The recruitment process is described in detail in the first paper of the present study.8 The online solution for the consent form and questionnaire was delivered by the Services for Sensitive Data (TSD) at the University of Oslo. At baseline, the respondents consented to follow-up questionnaires. At the 12 month follow-up, the baseline respondents received an automatic invitation from TSD to complete the questionnaire.
Questionnaire
The questionnaires have been described in previous publications.8 9 The present paper is based on 51 variables (online supplemental file 1): demographics from baseline, including self-reported previous symptoms of anxiety/depression (9 items). Moreover, questions on the COVID ICU-related factors professional preparedness, emotional experience and support at work (8 items), along with questions of planned or completed change of job, self-reported COVID-19 infection and collegial support, were included both at baseline and 12 month (3 items). In addition, a single question on vaccination at the 12 month follow-up was presented (1 item). Finally, the two validated questionnaires on psychological distress were included (30 items).
Supplemental material
Symptoms of anxiety and depression were measured using the Hopkins Symptoms Checklist-10 (HSCL-10). HSCL-10 regards symptoms experienced the last week and consists of 10 items, measuring symptoms of depression (6 items) and anxiety (4 items).11–13 Each item is graded on a 1–4-point Likert scale, and an average item score is calculated, here a score of 1. 85 or higher was considered to indicate caseness.11–13
Symptoms of post-traumatic stress disorder (PTSD) were measured using the PTSD checklist for the Diagnostic and Statistical Manual of Mental Disorders 5, PCL-5. PCL-5 is a 20-item screening tool for symptoms of traumatisation and the timeframe of symptoms is the last month.14 15 The 20 questions were answered in a Likert scale graded from 0 to 4, a sum score was calculated and a score of 31 or higher was considered to indicate caseness.14 15 In the heading of the PCL-5 questions, it was stated that the traumatising event had to be related to COVID ICU work.
The COVID ICU-related factors (8 items) were selected through a modified Delphi model practise.16 17 The research group consisted of both physicians and nurses with both clinical and research experience within the fields of intensive care, anaesthesiology, psychiatry and psycho-traumatology. After repeated rounds of discussions, the research group emphasising current literature and clinical experience, reached a consensus of three groups of factors: (1) professional preparations (professional preparedness, professional information and simulation training), (2) emotional experience (fear of infection and feeling of loneliness), and (3) support at work (no extra support, talk to leader and daily debrief).
Patients and public involvement
No patients were involved. A user representative, who was a member of the Norwegian Association of Intensive Care Nurses, participated during the whole process of developing the study design and during the data collection.
Statistical methods
The characteristics of the sample were described by mean with SD or median with IQR or frequencies with percentages and range (min–max) depending on the scale of the variable. Differences in the distributions in the scores of HSCL-10 and PCL-5 between the three professional groups were examined using the Kruskal-Wallis test. Changes in the scores of HSCL-10 and PCL-5 from baseline to 12 months were assessed by a Wilcoxon signed-rank test. Logistic regression was performed to test the predictive capacity of (1) previous anxiety and/or depression and (2) scores over the cut-off on the PCL-5 and HSCL-10 at baseline, using HSCL-10 and PCL-5 at 12 month as the dependent variable.
Median regression was performed to examine the association between demographic variables and the COVID ICU-related variables at baseline, and the scores of HSCL-10 and PCL-5 at 12 month follow-up as dependent variables. In the modified Delphi process, for selecting the COVID ICU-related variables collinearity was checked, and a Spearman’s rho>0.4 was set as the cut-off and the most clinically relevant variable was included in the analysis. Three variables were dichotomised for multivariate analysis. Simulation training was scored as: ‘not at all’ = ‘no’ and ‘once’ and ‘several times’ which was combined =‘yes’. Both professional preparedness and (3) feeling of loneliness were graded as a 5-point Likert scale ‘not at all’ and ‘to little degree’ were set to ‘no’, the three positive answers were set to ‘yes’. At 12 months ‘not applicable’ (NA) was an option for professional preparedness and simulation training, NA was coded as ‘yes’. Because of missing data on the outcome variables (197 non-responders of both PCL -5 and HSCL-10 at 12 months) and years of experience (3 missing values), the pooled results from multiple regression with 20 imputed data sets were reported for comparison purposes to a complete case analysis.18 Multiple imputation by chained equations under the assumption of missing at random were performed to handle the missing values. The strength of the association was quantified as the regression coefficient with 95% CIs. The significance level was set to 0.05. The analyses were performed with Stata/SE V.17.0 and IBM SPSS V.28.0 for Windows.
Ethical considerations
The current study was conducted according to the Declaration of Helsinki and was approved by the Regional Commitee for Medical and Health Research Ethics South-East Norway group A (2020/136144) and the data protective officer at Oslo University Hospital (20/09438). At each of the 27 hospitals, included the study was approved by the local data protective officer, the head of research and the local leaders. Every participant had to sign an electronic informed consent form and could withdraw from the study at any point by contacting the research leader. All sensitive data were stored using the Services for Sensitive Data (TSD) at the University of Oslo.
Results
Study population characteristics
A total of 287 (59.3%) of the 484 COVID ICU healthcare professionals enrolled at baseline, completed the online 12 month follow-up questionnaire. A flowchart is available in the supplemenatry section (online supplemental file 2). The demographic characteristics of the study population at baseline and at 12 month are displayed in table 1. Out of the 197 participants lost to follow-up, age was the only variable that was significantly different (ie, lower) (p=0.037). At the 12 month follow-up, 4.9% of the participants had changed workplaces and all were nurses. Moreover, 95.8% of our study population had been vaccinated, 83.3% with two dosages. Only 1% of the study population reported being infected with the COVID-19 virus.
Levels of distress, professional differences and predispositions
HSCL-10-scores and PCL-5-scores at baseline did not show a statistical difference in the population lost to follow-up (n=197) compared with the population that completed the 12 month follow-up questionnaire (n=287). Symptoms of anxiety and depression is displayed in table 2 and symptoms of post-traumatic stress is displayed in table 3. Anxiety, depression and PTSD at all three measurement times (n=206) is provided for comparison in the supplementay material (online supplemental file 3). The median score of symptoms of anxiety and depression at the 12 month follow-up was 1.2 and there was no significant increase in the median score from baseline. Nurses had significantly higher scores than physicians and leaders (p=0.019). The percentage of the study population that met the criteria for caseness was 12.5% at both baseline and 12 month. The median score of symptoms of post-traumatic stress at the 12 month follow-up was 7.0. There was a significant increase in median PCL-5 score (p=0.016) from baseline to 12 month follow-up and nurses were the sole profession that contributed significantly to this increase. Moreover, nurses had significantly higher PCL-5 scores than physicians and leaders at both baseline (p=0.019) and 12-month follow-up (p<0.001). The percentage of the study population that met the threshold for caseness was 6.3%, all of whom were nurses.
The total number of participants who met the caseness criteria for HSCL-10, PCL-5 or both at baseline were 39/287 (13.6%) and at 12 month follow-up 38/287 (13.2%). Of the 287 participants, 210 (73.2%) reported no previous symptoms of anxiety and/or depression, and of them 21 (10%) scored above cut-off on either HSCL-10 or PCL-5 or both at baseline. At the 12 month follow-up the numbers had decreased to 18 (8.6%). Of the 77 (26.8%) participants who reported either previous symptoms of depression or anxiety or both, 18 (24.7%) met caseness criteria either or both of HSCL-10 or PCL-5 at baseline, and at 12 months, 20 (26%) of them met caseness criteria. Previous symptoms of anxiety and/or depression increased the likelihood of caseness on HSCL-10 and/or PCL-5 at the 12 month follow-up with an OR of 2.9 (95% CI: 1.3 to 6.4, p=0.005). Caseness on HSCL-10 and/or PCL-5 at baseline increased the likelihood of caseness at 12 months with an OR of 8.4 (95% CI: 3.8 to 18.7, p<0.001), and this was more prominent among those who reported either previous symptoms of depression or anxiety (12/18, 66%) compared with those who did not report previous symptoms (6/21, 28.5%).
COVID ICU-related factors
Of the eight COVID ICU- related factors (graphically presented in online supplemental file 4) the major change during the 12 month period was the lessening in fear of infection, from 46.7% to 15.7%. The reported feeling of loneliness increased from 67.2% to 76.0% at the 12 month follow-up. There were no major changes in preparation or support at work. The most frequent support measure (not included in the multiple regression), during the study period, was collegial support and 83.2% (n=240) said this was supportive at 12 months, compared with baseline, 93.6% (n=453).
Multiple median regression
Table 4 shows the association between the demographic variables and the COVID ICU-related variables at baseline levels and the HSCL-10 score at 12 month follow-up. Self-reported previous symptoms of depression and fear of infection were significantly associated with higher HSCL-10 scores after being adjusted for the other covariates in the median regression model. Results from multiple imputation by chained equation showed similar findings (online supplemental file 5, table 1).
Table 5 shows the adjusted association between the demographic variables (table 1) and the COVID ICU-related variables at baseline levels and the PCL-5 score at the 12 month follow-up. Previous symptoms of depression, fear of infection and loneliness were significantly associated with higher PCL-5 scores adjusted for the other covariates in the median regression model. Similar results were found when multiple imputation by chained equation were performed (online supplemental file 5, table 2).
Discussion
Principal findings
In the current national, prospective, longitudinal study of COVID ICU nurses, physicians and their leaders, the primary finding at the 12 month follow-up was psychological distress among 13.2% of the study population. Nurses reported significantly higher levels of distress than physicians and leaders. Adjusting for the COVID ICU-related factors and demographics at baseline, fear of infection was significantly associated with higher symptom levels of anxiety, depression and post-traumatic stress, whereas feeling of loneliness was associated with higher levels of post-traumatic stress. Of the demographic factors, self-reported previous symptoms of depression were significantly associated with more anxiety, depression and post-traumatic stress symptoms. Gender, marital status or profession were not associated with significant influence of levels of psychological distress. Neither were professional preparations or support at work.
Strengths and limitations
To the best of our knowledge, there are no longitudinal and nationwide studies including healthcare professionals working in COVID ICUs during the first year of COVID-19. We included the core ICU professions: nurses and physicians, and their leaders and we followed the individuals for 12 months with a 59% response rate. A limitation is the lack of registers of nurses and physicians working in the COVID ICUs, which makes the response rate unknown. In addition, validated questionnaires (HSCL-10, PCL-5) do not have the accuracy of a diagnostic interview and may overestimate the prevalence of psychological distress.19 PTSD symptoms are often assessed after a single-potential traumatic event. In the present study, symptoms were assessed related to working under longitudinal potential stressful circumstances in COVID ICUs. The PCL-5 score may be lower in relation to the longitudinal approach and not assessed after a single traumatic event. The results of the HSCL-10 checklist might be influenced by aspects of life other than the COVID ICU experience. Because of small number of physicians and leaders, the generalisability of the results concerning these two groups are limited.
Comparison of levels of distress with those of other studies
We found substantially lower levels of anxiety and depression (12.5%) and post-traumatic stress symptoms (6.3%) than a systematic review of the COVID-19 pandemic effects on mental health that included 239 papers with all types of healthcare workers (n=271.319).20 The review covered studies published before March 2021 and 23% of the studies were European.20 Another systematic review of the first year of COVID-19 focused on the ICU setting and included 13 papers. Also, in this review, there were higher levels of distress. Symptoms of anxiety ranged from 31% to 60%, depressive symptoms from 16% to 65% and symptoms of PTSD from 14% to 47%.21 Most of the studies included in the two reviews were cross sectional. Longitudinal studies of comparable ICU healthcare professionals found no significant change in levels of distress during follow-up: A Dutch study of ICU nurses (n=164), from autumn 2020 to autumn 2021, reported constant, but higher levels of distress as 38.2% reached caseness.22 A German single-centre study also found mainly unchanged levels of distress during the 6 month follow-up of ICU personnel (n=49) and support of the lock-down contributing more to distress than the COVID-ICU work.23 Compared with non-ICU professionals, a British study of front-line physicians (n=3079) found the highest levels of distress in the acceleration phase, that is, early in the four months of spring 2020.24 Similar results were reported for British nurses and midwifes.25 In a single-centre study from Singapore with healthcare workers in the emergency department, they found a significant decrease in the symptom of anxiety after 1 year for all workers pooled, but an increase in the symptoms of depression among physicians.26 We found no significant change in the symptoms of anxiety and depression, but a significant increase in the PTSD symptoms only among the nurses during the study period. Compared with the prepandemic Norwegian population27–29 and a prepandemic study of ICU healthcare professionals,2 there were only minor differences in the data from the present study’s population.
Comparison of Findings of COVID ICU-Related Factors with Those of Other Studies
A systematic review including all types of healthcare professionals did not find any significant correlation with age, gender or profession.20 Several studies during COVID-19 have shown that both age (lower), gender (female) and profession (nurse) correlate significantly with higher levels of psychological distress.21 30 31 The COVID ICU-related factors associated with psychological distress were fear of infection, stigmatisation/isolation, witnessing colleagues getting infected, poor communications with supervisors, a lack of support from the administrative leadership, lack of personal protective equipment, insufficient rest, denying visitors and end-of-life-decisions;21 however, these factors have not been subject to a meta-analysis. In the present study, we did find some of the same factors: significant associations of psychological distress with fear of infection and loneliness. In a bivariate comparison of the professions, the nursing profession was associated with significantly higher levels of distress, however this association was not significant when adjusting for other demographic and COVID ICU-related factors. Furthermore, our study showed that previous depression was significantly associated with higher levels of distress. The same association has been reported in a review of work-related PTSD in general and after the SARS epidemic but has been less commonly assessed in COVID-19 research so far.32–34 Moreover, professional preparations and support at work had no significant effect in our study population. Almost all participants acknowledged the collegial support, also identified in a Swedish study of evaluation of implemented types of support.35
Possible explanations
Our findings of lower levels of psychological distress compared with similar healthcare professionals’ populations may be explained by the high level of professional experience among the study population, that the ICU capacity was never overextended in Norway during the pandemic, and that after 12 months, progress was made in most aspects of the handling of COVID-19 for both patients and professionals. ICU healthcare professionals are regularly exposed, at work, to end-of-life decisions and traumatic death,36 indicating a selection process like the ‘healthy-worker’-effect.37 Almost all our study participants had previous intensive care experience and a mean total work experience of almost 20 years. A survey of Norwegian physicians autumn 2020 found that those working in ‘COVID-19-exposed specialities’ had significantly lower odds of concern for infecting their family and although they perceived more scarcity of personal protective equipment (PPE) they had no raised odds of fear of getting oneself infected.38 A large proportion of our study population had personal resilience promoters: a partner and no prior symptoms of anxiety or depression, along with a specific for the COVID ICU task: no risk factors for serious COVID infection. The difference between the professions may be dual: choice of profession and the nature of the different professions’ work tasks.39 The nurses worked more bedside hours that entailed wearing PPE, which was physically demanding, and at baseline, the uncertainty of the safety of the equipment increased fear of infection among many, in addition to other emotional stressors like denying relatives to visitations.8 Although the prepandemic ICU capacity in Norway was among the lower in Europe,40 41 the ICU capacity was never overstretched because of a combination of ceasing elective surgery, construction of temporary ICUs and the authority’s early and strict lock-down of the rest of the society.42 Together, these measures led to low numbers of both infected and dead by the end of the 12 month follow-up data collection (June 2021): 2.4% of the Norwegian population were confirmed infected, and of those 0.015% had died, whereas in total for Europe, 12.3% of the population were infected, and of them, 2.6% had died.43 44 A survey from the first outbreak in Italy indicated that healthcare professionals in hospitals in high endemic areas like Lombardy reported significantly higher levels of psychological distress than colleagues in hospitals in low endemic areas like Tuscany.45 Along the same lines, a French study of ICU professionals reported significantly higher levels of distress among professionals working in hospitals in high intensity zones defined as >1 patient to the maximum number of ICU beds available in the hospital before COVID-19.46 During the first 12 months, COVID-19 knowledge advanced, treatment regimens were established, and the mortality rate was reduced. Hospitals were well equipped and better PPE was made available. Almost all of our study participants had been vaccinated and only 1% of the study population had been infected, compared with 2.4% of the total population.47
Contrary to expectations and previous studies, there was no significant effect of professional preparations and support at work on the levels of distress.34 This might be the results of a homogenous, experienced and resilient study population because 46.7% reported fear of infection, but only 13.2% reported significant psychological distress. Similar findings have been made in a study of Norwegian Medical Helicopter personnel, who are frequently exposed to highly traumatic events, but still reporting low levels of distress. This study remarks training and selection as well as organised peer support and being married/having a partner as possible explanations of the low levels.48 Finally, the significant association between feeling of loneliness and higher symptoms of PTSD is consistent with previous studies that corroborate social support as a protective measure after a traumatic event.34
Meaning and implications
To minimise psychological distress among ICU professionals in future epidemics, this study’s results support engaging experienced professionals and ability for immediate expansion of the ICU capacity. Furthermore, to prevent excess fear of infection, sufficient stocks of personal protective equipment and access to vaccines are important. In addition, organisational measures to facilitate peer-support and educational programmes on how to promote resilience and awareness of vulnerability factors like previous depression and loneliness should be encouraged.
Conclusion
The COVID ICU healthcare professionals in the present study reported low levels of psychological distress, this is probably explained by their experience and adequate ICU capacity. Nurses were at a higher risk of developing distress. According to the current study, the focus areas of prevention are mitigating fear of infection and loneliness. Future research might elaborate on both other psychological and the long-term effects of the COVID ICU experience.
Data availability statement
Data are available upon reasonable request. Because the respondents written informed consent data are not available upon request, we have provided an additional, non-author, point of contact that interested researchers can get in touch with to secure accuracy regarding our data.
Ethics statements
Patient consent for publication
Ethics approval
This study was approved by The Regional Committee for Medical and Health Research Ethics South-East Norway group A (2020/136144) and the data protective officer at Oslo University hospital (20/09438).
References
Supplementary materials
Supplementary Data
This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.
Footnotes
Contributors IL is the study guarantor. IL, JR, SS and ØE contributed to the study concept and design. IL, JR, SS, ØE, LS and ISH contributed to the construction of the study questionnaires. IL, SS and ISH contributed to the acquisition of data. LMD provided statistical advice and calculations. IL, JR, SS, ØE, LS, LMD, EH and ISH contributed to the interpretation of data and drafting of the manuscript.
Funding This research was supported by a grant from the Bergesen Foundation, Norway (reference BF-34138).
Competing interests None declared.
Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting or dissemination plans of this research.
Provenance and peer review Not commissioned; externally peer reviewed.
Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.