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Health and well-being of serving and ex-serving UK Armed Forces personnel: protocol for the fourth phase of a longitudinal cohort study
  1. Marie-Louise Sharp1,
  2. Margaret Jones1,
  3. Ray Leal1,
  4. Lisa Hull1,
  5. Sofia Franchini1,
  6. Niamh Molloy1,
  7. Howard Burdett1,
  8. Amos Simms2,
  9. Steven Parkes1,
  10. Daniel Leightley1,
  11. Neil Greenberg1,
  12. Dominic Murphy1,3,
  13. Deirdre MacManus4,
  14. Simon Wessely1,2,
  15. Sharon Stevelink1,
  16. Nicola T Fear1,2
  1. 1King's Centre for Military Health Research, Department of Psychological Medicine, King's College London, London, UK
  2. 2Academic Department of Military Mental Health, King's College London, London, UK
  3. 3Research Department, Combat Stress, Leatherhead, UK
  4. 4Department of Forensic and Neurodevelopmental Science, King's College London, London, UK
  1. Correspondence to Dr Marie-Louise Sharp; marie-louise.sharp{at}kcl.ac.uk

Abstract

Introduction This is the fourth phase of a longitudinal cohort study (2022–2023) to investigate the health and well-being of UK serving (Regulars and Reservists) and ex-serving personnel (veterans) who served during the era of the Iraq and Afghanistan conflicts. The cohort was established in 2003 and has collected data over three previous phases including Phase 1 (2004–2006), Phase 2 (2007–2009) and Phase 3 (2014–2016).

Methods and analysis Participants are eligible to take part if they completed the King’s Centre for Military Health Research Health and Wellbeing Cohort Study at Phase 3 (2014–2016) and consented to be recontacted (N=7608). Participants will be recruited through email, post and text message to complete an online or paper questionnaire. Data are being collected between January 2022 and September 2023. Health and well-being measures include measures used in previous phases that assess common mental disorders, post-traumatic stress disorder (PTSD) and alcohol misuse. Other areas of interest assess employment, help-seeking and family relationships. New topics include the impact of the British withdrawal from Afghanistan in 2021, complex PTSD (C-PTSD), illicit drug use, gambling and loneliness. Analyses will describe the effect size between groups deployed to Iraq and/or Afghanistan or not deployed, and those who are currently in service versus ex-service personnel, respectively, reporting prevalences with 95% CIs, and ORs with 95% CI. Multivariable logistic and multiple linear regression analyses will be conducted to assess various health and well-being outcomes and associations with risk and protective factors.

Ethics and dissemination Ethical approval has been granted by the Ministry of Defence Research Ethics Committee (Ref: 2061/MODREC/21). Participants are provided with information and agree to a series of consent statements before taking part. Findings will be disseminated to UK Armed Forces stakeholders and international research institutions through stakeholder meetings, project reports and scientific publications.

  • epidemiology
  • mental health
  • epidemiologic studies
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STRENGTHS AND LIMITATIONS OF THIS STUDY

  • Strengths of this study include recruitment from a cohort where underlying characteristics of participants are known, and longitudinal data are held on their health and well-being.

  • Strengths also include an original cohort sampling frame that recruited a random, representative sample of UK service personnel.

  • The study has maintained validated and harmonised health and well-being measures across phases, while including new areas relevant to the cohort’s current experiences.

  • Study limitations include recruitment from a specific era cohort; hence the study cannot comment on older era cohorts or those who joined the Armed Forces more recently.

  • Limitations also include loss to follow-up across cohort phases, which may lead to underestimation of alcohol misuse in the cohort.

Introduction

Context

The long-term health and well-being of serving (Regulars and Reservists) and ex-service personnel (veterans) is a key concern for the Government of the UK, Ministry of Defence (MOD) and the Office for Veterans’ Affairs (OVA), and is a main tenet of their current strategies.1 2 A focus on health and well-being throughout the life cycle of service in the Armed Forces helps support operational effectiveness and successful transitions to civilian life.3 4 In addition, this emphasis on health and well-being fulfils commitments made in the Armed Forces Covenant5 which aims to ensure that the UK Armed Forces community is not disadvantaged compared with the general population because of their military service. In 2022, a legal duty was placed on statutory bodies (government departments, agencies and public bodies) to give ‘due regard’ to the needs of the UK Armed Forces community.6 Hence, understanding the long-term health needs of current service and ex-service personnel is necessary to identify trends in health outcomes and inform prevention, early detection and intervention strategies for this group. This evidence can also direct statutory and voluntary sector resources to members of the Armed Forces community who may need support.

In 2003, the King’s Centre for Military Health Research (KCMHR) Health and Wellbeing Cohort Study was set up to assess the possible consequences of deployment to the Iraq conflict (Operation TELIC).7 Participants of the KCMHR Health and Wellbeing Cohort Study have been followed up over three main cohort time points with data collected between 2004–2006 (Phase 1), 2007–2009 (Phase 2) and 2014–2016 (Phase 3).7–9 The cohort has also been used to collect extra waves of data related to help-seeking, mental health of military fathers and their children and the impact of the COVID-19 pandemic on the veteran community.10–13 Within the main waves of cohort data collection, during Phase 1, KCMHR surveyed a random sample of Regular and Reserve personnel who were deployed on Operation TELIC 1 and, for comparison, a random sample of trained but non-deployed personnel. At Phase 2, KCMHR followed up the original cohort, and in addition, included a random sample of Regular and Reservist personnel who had deployed to Afghanistan (Operation HERRICK), and a replenishment sample of personnel who had joined service since the cohort was first recruited in 2004. The replenishment sample was to ensure the cohort was broadly representative of the UK Armed Forces at the time of sampling. At Phase 3, all previous cohort participants were followed-up and a further replenishment sample of personnel who joined the trained strength on or after 1 August 2009 was added to again ensure a broadly representative sample of the UK Armed Forces. By Phase 3 of the study, 40% of the sample had left service and transitioned to civilian life.

This study is a fourth wave of data collection (Phase 4 - 2022–2023) which includes both serving and ex-serving personnel (Regular and Reserves) who took part in Phase 3. In the UK and within this study, ex-service personnel/veterans are defined as anyone who has served for at least 1 day in His Majesty’s Armed Forces (Regular or Reservist).14 In Phase 4 there is no replenishment sample of current Armed Forces, as the aim is to transition to a legacy cohort, broadly representative of those who served during the Iraq and Afghanistan era of conflicts and who share specific service, deployment and combat experiences.

Current knowledge

While the majority of those who serve in the UK Armed Forces do not experience negative health outcomes from service, a significant minority may be at a higher risk of mental health problems and alcohol misuse compared with the UK general population.9 Risk factors for negative health outcomes include pre-service (childhood) vulnerabilities,15 exposures during service such as combat experiences,16 a military culture of alcohol use17 and difficulties experienced during and after transition to civilian life, such as a poor integration into civilian life and limited social support.18 Service personnel and veterans may also experience increased barriers to seeking help for mental health conditions compared with the general population which affects access and engagement with healthcare services.11

Over the three phases of the KCMHR cohort study, common mental disorders (CMDs) were the most prevalent outcome in Regular service and ex-service personnel ranging between 20–22%, followed by alcohol misuse reported at 10–15% and probable post-traumatic stress disorder (PTSD) at 4–6% prevalence.7–9 CMDs have remained stable over the three phases, alcohol misuse has steadily declined and probable PTSD increased from Phase 2 to Phase 3 from 4% to 6%. Broadly, the prevalence of CMD and probable PTSD at Phase 3 were similar to general population estimates, with alcohol misuse rates approximately two to three times higher than equivalent general population estimates.9 19 However, the prevalence of negative mental health outcomes was not uniform across groups, where ex-service personnel (compared with service personnel) who deployed in a combat role, reported higher levels of CMD, probable PTSD and alcohol misuse compared with equivalent general population estimates.9 19 20

In Phases 1 and 2, deployed Reservists reported higher levels of probable PTSD compared with deployed Regulars,21 however this difference did not persist at Phase 3 with probable PTSD reported at 7% in both Reservists and Regulars. Deployed Reservists have consistently reported higher rates of CMD, PTSD and alcohol misuse compared with non-deployed Reservists.9

Phase 4 of the study will be able to address questions regarding longer-term impacts of service, deployment and transition for this cohort that served during the Iraq and Afghanistan era of conflicts. The current phase will also provide new evidence in under-researched areas such as complex PTSD (C-PTSD),22 gambling,23 illicit drug use,24 mild cognitive impairment,25 and will be able to assess impacts of events such as the withdrawal of troops from Afghanistan26 and the COVID-19 pandemic.12 27 The study will provide a robust evidence base for the UK government and stakeholders, such as Armed Forces charities, to help shape policy and support services. This study will be able to compare outcomes with previous phases and the general population, as well as with Armed Forces populations from allied countries.

Research aims

The primary objective of Phase 4 of this longitudinal cohort study is to continue to describe the health and well-being of UK service and ex-service personnel, Regulars and Reservists, who served during the time of operations in Iraq (Operation TELIC) and Afghanistan (Operation HERRICK) and to describe the course of health outcomes over the Phases 1–4. Specific primary aims include being able to compare health outcomes between those who deployed to Iraq and/or Afghanistan and those that did not deploy, and between serving and ex-serving personnel. Other objectives are the assessment of a wider range of outcomes relevant to UK service and ex-service personnel. The study will assess:

  • Post-service mental health, lifestyle behaviours, social support and social exclusion.

  • The predictors and associations of separation from service for both Regulars and Reservists.

  • The prevalence of help-seeking for physical, mental health and alcohol problems and types of healthcare sources used.

  • The prevalence and factors associated with problem gambling.

  • The prevalence and factors associated with illicit drug use.

  • Marital/relationship satisfaction and the effect of military service on relationships.

  • The long-term health and social impact of alcohol misuse.

  • The prevalence and factors associated with self-harm and suicidal ideation before, during and after service.

  • The prevalence and factors associated with mild traumatic brain injury (mTBI) and post-concussion symptoms.

  • The prevalence and factors associated with anger, aggressive behaviour and interpersonal violence.

  • The prevalence and factors associated with mild cognitive decline.

  • The impact of the British withdrawal from the NATO mission in Afghanistan on the health and well-being of service and ex-service personnel.

Method and analysis

Study protocol

Sample population and eligibility

Participants will be recruited from those who responded at Phase 3 of the cohort study and who consented to future contact (N=7608). Phase 3 respondents will be recruited to ensure the study can compare and use health and exposure data from Phase 3 (2014–2016) in Phase 4 analyses at a minimum and make best use of time and resources when tracing participants with the most recent contact details from the last phase.

Data collection method and timeline

Data will be collected via an online or paper questionnaire. The online questionnaire will be accessed through Qualtrics software28 and will take approximately 40–45 min to complete. Participants invited to take part provided contact details during previous phases of the study. The MOD will provide updated contact details for participants who were in-service at the time of Phase 3. This data linkage will be carried out under a data usage agreement between the MOD and KCMHR which adheres to data protection legislation.

Data collection will be carried out over a period of approximately 20–22 months, starting January 2022 and anticipated to close in September 2023. Participants will be given as much time to decide if they wish to participate up until the end of data collection.

Initial contact

In the first instance, participants who have provided a personal email address at a previous phase will be invited to take part in the online survey by email. The email invite emphasises that participation is voluntary, confidential and will include a personalised questionnaire link, a link to the Participant Information Sheet (PIS) and a link to the study website. Where we do not hold a personal email address, participants will be invited to take part by post. An initial invite letter will be sent detailing how to take part in the study online.

Where email or postal addresses are found to be invalid, we will send invitations to alternative contact details that we hold, and we may also send a text message where possible to participants to invite them to take part and provide details of how to find out more about study.

Reminder invitations

Up to two reminders will be sent to those who have not completed the survey and have not refused participation. For those who have been contacted by email, a first reminder will be sent approximately 2 weeks after the initial invitation, and a second reminder approximately 2 weeks later. For those who have been invited to take part by post, we will send a postal pack including a personal link to take part in the online survey and a paper questionnaire, a reply-paid return envelope and a PIS. This will be mailed to either the most recent address held on our database, or any updated addresses provided by the MOD.

Follow-up and tracing of non-responders

Following the reminder invitations, several methods will be used to follow-up and trace non-responders. We will attempt to contact non-responders by telephone to check whether participants have received the study invitation and to answer any queries they may have about the study. Those who wish to take part will be sent a new invitation by email, text or post as preferred. If we are unable to reach participants by telephone or telephone numbers are no longer valid, we will check Directory Enquiries for updated numbers.

‘Final chance’ contact

Approximately 1 month before the end of data collection, all non-responders will be sent a ‘final chance’ email, text or letter detailing that the study data collection will close and describe how they can take part in the survey online or to request a paper questionnaire.

Other communication activities

Information about the study will be shared on the KCMHR website (KCMHR.org), through blogs, through social media posts on the KCMHR Twitter profile and through Armed Forces stakeholders’ newsletters and websites. Newsletters will be shared with the cohort members during data collection, informing participants of progress and providing further information about the study.

Study materials

The study will provide a website giving more information and links to the PIS, Signposting Booklet and privacy notice. The PIS provides detailed study information, answers to frequently asked questions and contact details for the research team. The options regarding refusal to take part and withdrawal from the study are explained in the PIS. The Signposting Booklet offers information about relevant support services. A link to the Signposting Booklet will be provided in the online survey and details will also be included in the paper questionnaire pack. A risk protocol is in place for participants that get in touch with the study team who are distressed and in need of signposting or immediate crisis help.

Financial incentives

As in previous phases, participants who complete a questionnaire will be given the opportunity to be entered into a prize draw to win an amount between £25 and £1000, either for themselves or a charity of their choice. The amount and number of each prize available will be clearly stated in the participant information. The prizes available will be 1× £1000, 2× £500, 5× £100, 5× £50, 10× £25. Entry into the prize draw is voluntary and the draw take place soon after the end of data collection.

Measures

As we are seeking to assess change, the principal outcome measures are the same screening measures used in previous phases (numbered 1–10). New measures at Phase 4, reflecting current topics of interest are numbered 11–18.

  1. 12-item General Health Questionnaire (GHQ-12) as a measure of general (non-psychotic) psychiatric morbidity. Cut-off indicating the presence of a CMD such as depression or anxiety ≥4.29

  2. 17-item PTSD Checklist (PCL-C) to measure probable PTSD. Cut-off for probable PTSD ≥50.30

  3. 20-item PCL-5 to measure probable PTSD. Cut-off for probable PTSD ≥38.31

  4. 10-item Alcohol Use Disorder Identification Test (AUDIT) to measure alcohol consumption and misuse. Cut-off for alcohol misuse ≥16.32

  5. 15-item Patient Health Questionnaire (PHQ-15) to measure multisymptom illness. Cut-off for multisymptom illness ≥10.33

  6. Two items from the Brief Traumatic Brain Injury Screen (BTBIS) as a measure of mTBI.34

  7. Domestic abuse questions from Adult Psychiatric Morbidity Survey 2014 (APMS).19

  8. Three items selected from the Short Form (SF36) Quality of Life measure.35

  9. 5-item Dimensions of Anger Reactions (DAR-5). Cut-off ≥12 to denote anger difficulties.36

  10. 4-item measure of aggressive behaviour used by the Walter Reed Army Institute of Research.37

  11. 4-item Drug Use Disorders Identification Test (DUDIT). Cut-off for drug related problems >5.38

  12. Three suicidal ideation/self-harm items taken from the Clinical Interview Schedule-Revised (CIS-R)12 and used in the Adult Psychiatric Morbidity Survey.39

  13. Problem Gambling Severity Index (PGSI). Cut-off for problem gambling ≥8.40

  14. 4-item Dyadic Adjustment Scale (DAS-4) of marital/relationship quality.41

  15. 3-item UCLA Loneliness Scale. Cut-off for loneliness ≥6.42

  16. Oslo Social Support Scale (OSSS-3),43 scoring as per Bøen et al.44

  17. The International Trauma Questionnaire (ITQ) to measure C-PTSD, scoring as per Cloitre et al.45

  18. 16-Item Informant Questionnaire on Cognitive Decline (IQCODE Short Form). Scores summed and divided by 16, cut-off ≥3.31.46

From 2013, the definition of PTSD changed from DSM-IV to DSM-5. A new PCL-5 measure was introduced in our cohort to reflect the changes. To continue to compare the level of probable PTSD across phases but to also be able to report current probable PTSD using the new definition, a blended PCL measure will be included that allows the creation of both a PCL-C and a PCL-5 measure.

Other key topics will include questions regarding social and military demographic characteristics, employment, finances, accommodation and living arrangements, experience of Reserve service, help-seeking for health problems, impact of the Afghanistan withdrawal and COVID-19. The questionnaire is primarily quantitative in nature (tick box choices), however there are free-text boxes that participants can fill in regarding (1) listing operations of more than 30 days that participants have deployed on since the beginning of 2015, (2) describing any impact of military career on marriage, relationships or children and (3) adding any other information at the end of the questionnaire that the participant believes is important for the research team to know.

Power calculations

At Phase 3, the response rate among those who had participated in previous phases was 58%. Among those who were new to the study (replenishment group), the response rate was lower. However, at Phase 4 we will only include those who participated at Phase 3, that is, there will be no new participants. We therefore anticipate a response rate of at least 50–60% at Phase 4. With 7608 available for recontact, a response rate of 60% would result in 4565 participants at Phase 4.

The statistical power and sample sizes for all phases have been based on the prevalence of probable PSTD which, within this study, is the outcome of interest with the lowest prevalence.7–9 The planned study design will allow us to conduct two main analyses: (1) cross-sectional and (2) longitudinal.

Cross-sectional analyses

A primary aim is to continue to monitor the mental health of personnel who have deployed on operations to Iraq and Afghanistan compared with personnel who did not deploy on those operations. Assuming 4565 responses at Phase 4 and assuming 62% will have deployed to Iraq or Afghanistan (as at Phase 3): deployed (n=2830), non-deployed (n=1735). Assuming a prevalence of PTSD of 5.0% in the non-deployed group (prevalence at Phase 39), we would have more than 90% power to detect a 2.5% difference in the deployed group compared with the non-deployed group. This calculation is based on the difference between two proportions with 95% confidence (two-sided) and based on unequal sample sizes.

A second primary aim is to compare the prevalence of PTSD in serving and ex-service personnel. Assuming 4565 responses at Phase 4 and assuming 70% will have left service: ex-service (n=3196), serving (n=1369). Assuming a prevalence of PTSD of 4.6% in the serving group (prevalence at Phase 3), we would have more than 90% power to detect a 2.5% difference in the ex-service group compared with the serving group. This calculation is based on the difference between two proportions with 95% confidence (two-sided) and based on unequal sample sizes.

Longitudinal analyses

The aim is to detect a change in the prevalence of PTSD at Phase 4 compared with previous phases in the whole sample. Assuming a prevalence for probable PTSD of 6.2% (prevalence in whole sample at Phase 3), a sample size of 4565 pairs would have over 90% power to detect an increased prevalence to 7.7% (difference in proportions of 0.015) with an alpha of 0.05 (two-sided). This is assuming that two-thirds of the original 6.2% will recover.47 This calculation is based on McNemar’s test of equality of paired proportions with 95% confidence (two-sided).

Statistical methods

Statistical analysis will be carried out using statistical packages such as Stata, SPSS and Mplus. The main analyses will compare mental health status according to deployment experiences and serving status, reporting prevalences with 95% CI, and ORs with 95% CI, to describe the effect size between groups deployed to Iraq and/or Afghanistan or not deployed, and those who are current service personnel versus those who are ex-service personnel, respectively. We will use paired t-tests for continuous outcomes, and McNemar’s tests for dichotomous outcomes, to compare prevalence in outcomes between phases. Multivariable logistic and multiple linear regression analyses will be conducted to assess mental health outcomes and associations with risk and protective factors. Regression analyses will control for a priori confounders identified relevant to the specific research question, for example, age, sex, rank, service branch, enlistment status (Regular/Reserve).

Further analyses will determine risk factors for new cases of key outcomes based on responses at previous phases, as well as factors associated with improvement of symptoms, using multiple logistic regression and multinomial logistic regression. Approaches such as but not limited to, latent class growth analysis and growth mixture modelling will be used to study trajectories of, for example, PTSD and alcohol use. Structural equation modelling will be used to assess mediators and indirect effects.

The response rate will be calculated as per previous phases7–9 (number responding divided by number in sample at Phase 4, multiplied by 100). We will report an adjusted response rate calculated as the number responding divided by the number in sample at Phase 4, minus the number of deaths and those who are uncontactable due to incorrect contact details, multiplied by 100.

Response weights will be calculated as the inverse probability of responding once sampled (at the appropriate phase) driven by factors shown empirically to predict response. Sample weights will be calculated as the inverse probability of an individual being sampled at Phase 1, 2 or 3. Combined sample and response survey weights will be used to account for differential response rates and sampling fractions in all analyses. All screening measures will be scored according to published instructions. Missing items on measures will be handled according to the protocol used in the previous phases, that is, for example on GHQ-12, PCL-17, PCL-5 and AUDIT, the lowest value is imputed if fewer than four items are missing on the measure. The free-text boxes may be further analysed quantitatively or qualitatively as deemed appropriate by the research team, for example, by using content analysis or reflective thematic analysis.48

Patient and public involvement

Veterans from the Veterans Research Advisory Group tested the design and flow of the questionnaire and offered advice on outcome measures. The Advisory Group were specifically consulted on questions and items assessing the impact of the British withdrawal from the NATO mission in Afghanistan. Results of the study will be disseminated to participants through a newsletter, our social media outlets, and through stakeholders that represent Armed Forces communities.

Data storage and security

Database

Personal information which identifies individuals (such as date of birth, service number) will be stored in an encrypted database on a restricted server, accessible only within KCMHR offices, and only by specified, authorised, members of the team. Access to the server is via an allocated login and password, which is unique for each researcher.

Pseudonymisation of questionnaire data

Individuals were assigned a unique ID by the MOD at the point of sampling. A second unique ID number has been generated by KCMHR to identify records in data sets for analysis allowing survey data to be held pseudonymously. Questionnaire data will be stored separately to the identifiable data in both electronic and paper format. Hard copy versions of the questionnaire will include a ‘contact sheet’ enabling participants to provide preferred contact details and consent information. The contact sheet will be removed and stored separately from the questionnaire; both will be labelled with the participant ID number.

Data entry of paper questionnaires

The hard copy questionnaire data and contact form will be entered in-house by the research team using Qualtrics. The paper questionnaire will be checked for inaccuracies and unclear responses which will be flagged and then reviewed by the Project Manager.

Data management and oversight

All research staff are provided with training regarding the General Data Protection Regulation, King’s College London (KCL) standards for handling data and Medical Research Council (MRC) data protection training.49

Data required for analysis will be extracted from the KCMHR secure system in pseudonymised form and stored on KCL OneDrive. We will use a valid Data Protection and Security Toolkit from KCMHR at KCL and will follow this Toolkit during rollout. Pseudo-anonymous data sets may also be shared with other Institutions under Data Sharing Agreements. This will be stated in the Participant Information Sheet and study privacy notice. Data will be kept by KCMHR for 20 years in line with MRC guidelines and we may use the pseudonymous data in future research.

Ethics and dissemination

Full ethical approval has been granted by the UK Ministry of Defence Research Ethics Committee (Ref: 2061/MODREC/21).

Consent

Participants are provided with information and consent will be taken at the beginning of the questionnaire. This is a list of statements to which participants can indicate whether they agree with each statement. For the online survey, this will be through the online platform allowing for consent to be recorded electronically. Statements include consents to take part in the Phase 4 questionnaire, consent to use participant data for future research, consent for contact from the research team for future research studies and consents for data linkage of participant personal data with central/national information centres as described in detail in the PIS. The PIS also explains that if participants have taken part and wish to withdraw their data, they are able to do so up until the end of data collection by informing the study team who will remove and delete their questionnaire data.

Dissemination

Results will be written up in academic papers and submitted for peer-reviewed publication. No identifying information will be presented in any reports or publications. Aggregated data will be made available in a final report to the funder and in future academic publications, but consideration will be given to cells with small numbers and may be suppressed. A final study report will be presented to the OVA, and academic publications will be disseminated through KCL communications channels in social media, press briefings, and academic conferences.

Discussion

The Health and Well-being Study of serving and ex-serving UK Armed Forces personnel is a longitudinal cohort study investigating the impact of service in the Armed Forces on those who served during the time of the recent Iraq and Afghanistan conflicts. This current (fourth) phase of data collection (2022–2023) will recruit from participants who took part in Phase 3 of the study. The study strengths include recruitment from a population where underlying characteristics are known, providing longitudinal data on health and well-being, and the use of harmonised and validated measures for mental health and well-being outcomes. Additional study strengths include new measures added into Phase 4 to keep the study relevant to cohort experiences and include new psychological measures. The study additionally benefits from an original sampling frame that recruited a random representative sample of UK Armed Forces.

Study limitations include recruitment from a specific era cohort that served during the Iraq and Afghanistan conflicts; hence the study may not reflect experiences of older era cohorts or more recent recruits in the UK Armed Forces. While the study has experienced fairly high levels of response rates over the cohort phases (44–59%7–9) and has consistently applied response and sample weights to mitigate bias, the study has limitations by loss to follow-up. The characteristics of non-response have not changed since the start of the cohort study: responders are significantly more likely to be older, women, Regulars, hold Officer rank and have served in the Royal Air Force (compared with the Navy or Army).9 An important finding at Phase 3 was that poorer mental health at Phase 2 did not predict response at Phase 3, suggesting that response was not biased by the main outcome. However, those who reported symptoms of alcohol misuse at Phase 2 were less likely to respond at Phase 3 which could underestimate the prevalence of alcohol misuse in the cohort in future phases. The study team at each phase however has learnt and adapted techniques to trace cohort participants50 and will again use a variety of engagement methods to increase response rates.

Ethics statements

Patient consent for publication

Acknowledgments

Thank you to all our King’s Centre for Military Health Research colleagues and the veterans who helped to edit and shape the survey questionnaire.

References

Footnotes

  • Twitter @MarieLouiseLu

  • Contributors M-LS, MJ, RL, LH, HB, AS, DL, NG, DMu, DMa, SW, SS and NTF were involved in the original concept and design of the study and questionnaire. NTF, SS and SW have overseen the conduct of all aspects of the study. RL and DL led on online survey design, format and flow. MJ, LH and M-LS led on the ethics submission with substantial contributions from RL, HB, AS, DL, NG, DMu, SW, SS and NTF. MJ and LH led on the design of participant materials including the participant invite and information sheet with input from all authors. MJ and M-LS led on the data analysis plan with input from HB, SW, SS and NTF. M-LS led the writing of the protocol paper, with drafting and revision from MJ, RL, LH, SF, NM, HB, AS, SP, DL, NG, DMu, DMa, SW, SS and NTF. All named authors have all approved the final version of this paper and accept accountability for all aspects of the work.

  • Funding This project is being funded by the Office for Veterans’ Affairs, Cabinet Office, UK Government (Contract Ref: CCZZ20A88).

  • Competing interests M-LS, MJ, LH, SF and NM salaries are funded through a grant by the Office for Veterans’ Affairs (OVA). RL and HB salaries are part funded through a grant by the OVA. AS is a serving Regular member of the British Army, salaried and seconded by the Ministry of Defence (MOD) to King’s College London. DL is a Reservist in the UK Armed Forces. This work has been undertaken as part of his civilian employment. NG is affiliated to the National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Emergency Preparedness and Response at King’s College London in partnership with Public Health England, in collaboration with the University of East Anglia and Newcastle University and is also a trustee with the Faculty and Society of Occupational Medicine. DMu is a trustee of the Forces in Mind Trust (unpaid) and is employed as the Head of Research for Combat Stress, a UK veterans mental health charity. DMa is employed as joint head of service of the London NHS Veterans Mental Health and Wellbeing Service (Op Courage). SS is supported by the NIHR Maudsley Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and funded by the National Institute for Health and Care Research, NIHR Advanced Fellowship, Dr Sharon Stevelink, NIHR300592. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care. SW is Honorary Civilian Consultant Advisor in Psychiatry for the British Army (unpaid) and is a board member of NHS England. SW is affiliated to the NIHR HPRU in Emergency Preparedness and Response at King’s College London in partnership with Public Health England, in collaboration with the University of East Anglia and Newcastle University. NTF is a trustee of Help for Heroes—a charity supporting the well-being of veterans and their families, and their salary is part grant funded by the MOD. SP declares no competing interests.

  • Patient and public involvement Patients and/or the public were involved in the design, or conduct, or reporting, or dissemination plans of this research. Refer to the Methods section for further details.

  • Provenance and peer review Not commissioned; externally peer reviewed.