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Malaria vaccine-related adverse events among children under 5 in sub-Saharan Africa: systematic review and meta-analysis protocol
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  • Published on:
    The R21/Matrix-M vaccine is a new 2nd malaria vaccine recommended by the World Health Organization (WHO) for the prevention of plasmodium falciparum malaria in children
    • Professor Dr Pranab Kumar Bhattacharya, Retired Professor and Head of Pathology department Retired from Calcutta School of Tropical Medicine 108 Chittaranjan Avenue Kolkata 73West Bengal India

    Dear Editor
    The R21/Matrix-M vaccine is a new vaccine recommended by the World Health Organization (WHO) for the prevention of malaria in children below age 5 years , in pregnant women, in travellers and individuals with HIV and AIDS (1) . It is the second malaria vaccine recommended by WHO, following the first RTS,S/AS01 vaccine, which received a WHO recommendation in 2021 (1) . The R21 vaccine is shown to be safe and effective in preventing malaria in children and, when implemented broadly, is expected to have high public health impact (1) in the rainy season.
    The R21/Matrix-M vaccine was developed by the University of Oxford and is a low-dose vaccine that can be manufactured at mass scale and modest cost, enabling as many as hundreds of millions of doses to be supplied to African countries which are suffering a significant malaria burden (3) . The vaccine targets the first form of the malaria parasite (the plasmodium sporozoite) to enter the body after a person is bitten by an infected mosquito (2)
    The updated WHO malaria vaccine recommendation is informed by evidence from an ongoing R21 vaccine clinical trial and other studies, which showed high efficacy when given just before the high transmission season. In areas with highly seasonal malaria transmission (where malaria transmission is largely limited to 4 or 5 months per year as it is in Ghana and Nigeria), the R21 vaccine was shown to reduce symptomatic cases of malaria by 75%-77% during the 12...

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    Conflict of Interest:
    None declared.