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  • Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study

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Influence of letermovir treatment on gut inflammation in people living with HIV on antiretroviral therapy: protocol of the open-label controlled randomised CIAO study
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  • Published on: 7 February 2023
    Great study but what about the effect on the CD4/CD8 ratio

    hi-
    This seems like a really interesting, and potentially very important study. I'm concerned though that you are not listing as a primary objective improving the CD4/CD8 ratio. While a home run could be decreasing the reservoir, whether you decrease the reservoir or not, you might improve the ratio and this by itself could alter future cancer susceptibility (anal, colon, lung) and may avoid zoster, or tb acquisition (if in India for example) and could improve immune response to vaccines. I'm not saying all of this naturally follows, but if you beat down CMV it is at least as likely that you make the immune system less distracted then it is you decrease the reservoir. Thanks for getting this together though and I look forward to the outcomes. Rob Striker UW Madison

    Conflict of Interest:
    None declared.