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Flavonoids for viral acute respiratory tract infections: protocol for a systematic review and meta-analysis of randomised controlled trials
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  • Published on: 3 January 2023
    Do green tea flavonoids have an impact on COVID-related respiratory tract infections?
    • Dujanand Singh, Colorectal PhD resercher West china Hospital
    • Other Contributors:
      • Yang Lie, Director of Division of Gastrointestinal Surgery, Department of General Surgery
      • Zongguang Zhou, Former Director of Department of Gastrointestinal Surgery

    Dear Editor

    I recently read the article entitled “Flavonoids for viral acute respiratory tract infections: protocol for a systematic review and meta-analysis of randomized controlled trials”

    I'd like to thank the authors for their excellent review and meta-analysis paper, which shows how flavonoids can help with viral acute respiratory tract infections. The article mentioned its role in viral ARTIs such as COVID-19, caused by SARS-CoV-2. Flavonoids have been supported for use in the prevention and treatment of ARTIs because they have antiviral, anti-inflammatory, cytotoxic, antibacterial, antioxidant, and anti-allergic characteristics. However, flavonoids are found in a wide range of phytonutrients. The United States Department of Agriculture (USDA) Database categorizes flavonoid foods as containing flavonols, flavones, flavanones, catechins (flavan-3-ols or flavanols), isoflavones, anthocyanins, and oligomeric or polymeric flavonoids.

    It would have been very helpful if the authors had suggested a specific flavonoid group or chemical structure that might have a positive response to SARS-Covid. For instance, in a Shanghai cohort study, a urine biomarker of tea polyphenol and the risk of colorectal cancer were investigated.[1] The opinion would have been highly appreciated, especially now when COVID is increasing dramatically in various variants and, in China, almost everyone consumes flavonoids in the form of green tea on a daily basis. The suggest...

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    Conflict of Interest:
    None declared.