You are here

  • Home
  • Archive
  • Volume 12, Issue 7
  • Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Article info

Article menu

Download PDFPDF

Neurology
Protocol
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

Authors

  • Charis Wong Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Rachel S Dakin Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Jill Williamson Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Judith Newton Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Michelle Steven Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Shuna Colville Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Maria Stavrou Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Jenna M Gregory Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK PubMed articlesGoogle scholar articles
  • Elizabeth Elliott Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Arpan R Mehta Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Jeremy Chataway Queen Square Multiple Sclerosis Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK National Institute for Health Research, University College London Hospitals, Biomedical Research Centre, London, UK Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK PubMed articlesGoogle scholar articles
  • Robert J Swingler Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK London North West University Healthcare NHS Trust, Northwick Park Hospital, London, UK PubMed articlesGoogle scholar articles
  • Richard Anthony Parker Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Christopher J Weir Edinburgh Clinical Trials Unit, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Nigel Stallard Statistics and Epidemiology, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK PubMed articlesGoogle scholar articles
  • Mahesh K B Parmar Medical Research Council Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK PubMed articlesGoogle scholar articles
  • Malcolm R Macleod Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Suvankar Pal Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  • Siddharthan Chandran Centre of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK Euan MacDonald Centre for Motor Neuron Disease Research, University of Edinburgh, Edinburgh, UK Anne Rowling Regenerative Neurology Clinic, University of Edinburgh, Edinburgh, UK UK Dementia Research Institute Edinburgh, University of Edinburgh, Edinburgh, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Suvankar Pal; suvankar.pal{at}ed.ac.uk; Siddharthan Chandran; Siddharthan.Chandran{at}ed.ac.uk
View Full Text

Citation

Wong C, Dakin RS, Williamson J, et al
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease
BMJ Open 2022;12:e064173. doi: 10.1136/bmjopen-2022-064173

Publication history

  • Received April 25, 2022
  • Accepted May 17, 2022
  • First published July 7, 2022.
Online issue publication 
July 07, 2022
Previous versions
Review history

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.