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  • Embryo selection through non-invasive preimplantation genetic testing with cell-free DNA in spent culture media: a protocol for a multicentre, double-blind, randomised controlled trial

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Obstetrics and gynaecology
Protocol
Embryo selection through non-invasive preimplantation genetic testing with cell-free DNA in spent culture media: a protocol for a multicentre, double-blind, randomised controlled trial

Authors

  • Jin Huang Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China PubMed articlesGoogle scholar articles
  • Rong Li Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China PubMed articlesGoogle scholar articles
  • Lin Zeng Research Centre of Clinical Epidemiology, Peking University Third Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Liang Hu Institute of Reproductive and Stem Cell Engineering, NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, ChinaClinical Research Centre for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, ChinaHunan International Scientific and Technological Cooperation base of Development and Carcinogenesis, Changsha, China PubMed articlesGoogle scholar articles
  • Juanzi Shi Northwest Women’s and Children’s Hospital, Xi'an, China PubMed articlesGoogle scholar articles
  • Liyi Cai Reproductive Medical Center of Hebei Maternity Hospital, Shijiazhuang, China PubMed articlesGoogle scholar articles
  • Bing Yao Affiliated Jinling Hospital, Nanjing, China PubMed articlesGoogle scholar articles
  • Xiu-Xia Wang Shengjing Hospital of China Medical University, Shenyang, China PubMed articlesGoogle scholar articles
  • Yanwen Xu Centre for Reproductive Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaGuangdong Provincial Key Laboratory of Reproductive Medicine, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China PubMed articlesGoogle scholar articles
  • Yuanqing Yao Department of Obstetrics and Gynecology, Chinese People’s Liberation Army General Hospital, Beijing, China PubMed articlesGoogle scholar articles
  • Yan Wang Department of Obstetrics and Gynecology, Sichuan University West China Second University Hospital, Chengdu, Sichuan, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, Sichuan, China PubMed articlesGoogle scholar articles
  • Junzhao Zhao Department of Obstetrics and Gynecology, Wenzhou Medical College Second Affiliated Hospital, Wenzhou, China PubMed articlesGoogle scholar articles
  • Yichun Guan Reproductive Medicine Center, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China PubMed articlesGoogle scholar articles
  • Weiping Qian The Center of Reproductive Medicine, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China PubMed articlesGoogle scholar articles
  • Guimin Hao Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China PubMed articlesGoogle scholar articles
  • Sijia Lu Xukang Medical Technology (Suzhou) Co., Ltd, Suzhou, ChinaYikon Genomics Company, Ltd, Suzhou, China PubMed articlesGoogle scholar articles
  • Ping Liu Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China PubMed articlesGoogle scholar articles
  • Jie Qiao Centre for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaNational Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, ChinaKey Laboratory of Assisted Reproduction (Peking University), Ministry of Education, Beijing, ChinaBeijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jie Qiao; Jie.qiao{at}263.net; Dr Ping Liu; pingliu7703{at}sina.com
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Citation

Huang J, Li R, Zeng L, et al
Embryo selection through non-invasive preimplantation genetic testing with cell-free DNA in spent culture media: a protocol for a multicentre, double-blind, randomised controlled trial
BMJ Open 2022;12:e057254. doi: 10.1136/bmjopen-2021-057254

Publication history

  • Received September 9, 2021
  • Accepted May 23, 2022
  • First published July 27, 2022.
Online issue publication 
July 27, 2022
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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.