Article Text
Abstract
Objective This systematic review aimed in assessing the effects of different weaning protocols in people with neuromuscular disease (NMD) receiving invasive mechanical ventilation, identifying which protocol is the best and how different protocols can affect weaning outcome success, duration of weaning, intensive care unit (ICU) and hospital stay and mortality.
Design Systematic review.
Data sources Electronic databases (MEDLINE, EMBASE, Web of Science and Scopus) were searched from January 2009 to August 2020.
Eligibility criteria for selecting studies Randomised controlled trials (RCTs) and non-RCT that evaluated patients with NMD (adults and children from 5 years old) in the weaning process managed with a protocol (pressure support ventilation; synchronised intermittent mandatory ventilation; continuous positive airway pressure; ‘T’ piece).
Primary outcome Weaning success.
Secondary outcomes Weaning duration, ICU stay, hospital stay, ICU mortality, complications (pneumothorax, ventilation-associated pneumonia).
Data extraction and synthesis Two review authors assessed the titles and the abstracts for inclusion and reviewed the full texts independently.
Results We found no studies that fulfilled the inclusion criteria.
Conclusions The absence of studies about different weaning protocols for patients with NMD does not allow concluding the superiority of any specific weaning protocol for patients with NMD or determining the impact of different types of protocols on other outcomes. The result of this review encourages further studies.
PROSPERO registration number CRD42019117393.
- neuromuscular disease
- respiratory medicine (see thoracic medicine)
- intensive & critical care
Data availability statement
No data are available.
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Data availability statement
No data are available.
Supplementary materials
Supplementary Data
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Footnotes
Twitter @vanessaresqueti
Contributors Data curation: SCGBN and RT-C. Formal analysis: SCGBN and RT-C. Methodology: SCGBN, RT-C and IL. Resources: VRR and GAFF. Writing-original draft: SCGBN, RT-C and GAFF. Writing-review and editing: SCGBN, RT-C, IL, VRR and GAFF. No additional data available.
Funding The study received financial support from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (https://www.gov.br/cases/pt-br), PGCI CAPES 054/2014 - 23038.007514/2014-78. GAFF received a grant from CNPq (https://www.cnpq.br) number 312876/2018-1, and VRR received a grant from CNPq (https://www.cnpq.br) number 315580/2018-6.
Disclaimer The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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