Download PDFPDF

Original research
Association between low-density lipoprotein cholesterol level and mortality in patients with cardiogenic shock: a retrospective cohort study
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests


  • A rapid response is a moderated but not peer reviewed online response to a published article in a BMJ journal; it will not receive a DOI and will not be indexed unless it is also republished as a Letter, Correspondence or as other content. Find out more about rapid responses.
  • We intend to post all responses which are approved by the Editor, within 14 days (BMJ Journals) or 24 hours (The BMJ), however timeframes cannot be guaranteed. Responses must comply with our requirements and should contribute substantially to the topic, but it is at our absolute discretion whether we publish a response, and we reserve the right to edit or remove responses before and after publication and also republish some or all in other BMJ publications, including third party local editions in other countries and languages
  • Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future.
  • By submitting this rapid response you are agreeing to our terms and conditions for rapid responses and understand that your personal data will be processed in accordance with those terms and our privacy notice.
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    More evidence that high LDL-cholesterol is beneficial
    • Uffe Ravnskov, Independent researcher Not affiliated with any institution

    That the mortality of patients with cardiogenic shock is inversely associated with low-density-lipoprotein cholesterol (LDL-C), as documented by Jin et al.1 is in accordance with our reviews of 38 studies, where the authors had followed more than six million people of all ages for several years after having measured their LDL-C.2,3 In almost all of the studies those with high LDL-C lived just as long or longer than those with normal or low LDL-C. These findings are of course most surprising because according to the official guidelines, high LDL-C is an important risk factor for cardiovascular disease (CVD), the commonest cause of death in most countries.

    However, many other contradictory observations have been ignored by the guideline authors as well.4,5 For example, people with low cholesterol become just as atherosclerotic as people with high cholesterol;5 LDL-C of patients with acute myocardial infarction is lower than normal and if it is lowered even more, their risk of dying prematurely increases.5 Furthermore, there is no exposure-response in the statin trials.5

    Familial hypercholesterolemia (FH) is seen as a strong argument for the view that high cholesterol is the main cause of CVD, although multiple studies are contradictive.6 For instance, three large follow-up studies of people with FH have found that on average, they lived just as long or longer than other people.6 The few who suffer prematurely from CVD have inherited increased levels of vario...

    Show More
    Conflict of Interest:
    None declared.