Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson’s disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: The ‘Exenatide-PD3’ study

Nirosen Vijiaratnam; Christine Girges; Grace Auld; Marisa Chau; Kate Maclagan; Alexa King; Simon Skene; Kashfia Chowdhury; Steve Hibbert; Huw Morris; Patricia Limousin; Dilan Athauda; Camille B Carroll; Michele T Hu; Monty Silverdale; Gordon W Duncan; Ray Chaudhuri; Christine Lo; Silvia Del Din; Alison J Yarnall; Lynn Rochester; Rachel Gibson; John Dickson; Rachael Hunter; Vincenzo Libri; Thomas Foltynie

doi:10.1136/bmjopen-2020-047993

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Neurology

Protocol

Exenatide once weekly over 2 years as a potential disease-modifying treatment for Parkinson’s disease: protocol for a multicentre, randomised, double blind, parallel group, placebo controlled, phase 3 trial: The ‘Exenatide-PD3’ study

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Nirosen Vijiaratnam Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UKNational Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles
Christine Girges Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UKNational Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles
Grace Auld The Comprehensive Clinical Trials Unit, UCL, London, UK PubMed articles Google scholar articles
Marisa Chau The Comprehensive Clinical Trials Unit, UCL, London, UK PubMed articles Google scholar articles
Kate Maclagan The Comprehensive Clinical Trials Unit, UCL, London, UK PubMed articles Google scholar articles
Alexa King The Comprehensive Clinical Trials Unit, UCL, London, UK PubMed articles Google scholar articles
Simon Skene Surrey Clinical Trials Unit, University of Surrey, Guildford, UKDepartment of Clinical & Experimental Medicine, University of Surrey, Guildford, UK PubMed articles Google scholar articles
Kashfia Chowdhury The Comprehensive Clinical Trials Unit, UCL, London, UK PubMed articles Google scholar articles
Steve Hibbert The Comprehensive Clinical Trials Unit, UCL, London, UK PubMed articles Google scholar articles
Huw Morris Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UKNational Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles
Patricia Limousin Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UKNational Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles
Dilan Athauda Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UKNational Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles
Camille B Carroll Applied Parkinson"s Research Group, University of Plymouth, Plymouth, UKUniversity Hospitals Plymouth NHS Trust, Plymouth, UK PubMed articles Google scholar articles
Michele T Hu Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, Oxfordshire, UKOxford Parkinson"s Disease Centre, University of Oxford, Oxford, UKDepartment of Clinical Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Monty Silverdale Department of Neurology and Neurosurgery, University of Manchester, Greater Manchester, UK PubMed articles Google scholar articles
Gordon W Duncan Western General Hospital, NHS Lothian, Edinburgh, UKUniversity of Edinburgh, Edinburgh, UK PubMed articles Google scholar articles
Ray Chaudhuri Parkinson"s Foundation International Centre of Excellence, King\"s College London, London, UK PubMed articles Google scholar articles
Christine Lo Oxford Parkinson"s Disease Centre, University of Oxford, Oxford, UK PubMed articles Google scholar articles
Silvia Del Din Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Alison J Yarnall Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UKNewcastle Upon Tyne NHS Foundation Trust, Newcastle, UK PubMed articles Google scholar articles
Lynn Rochester Translational & Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Rachel Gibson London, UK PubMed articles Google scholar articles
John Dickson Department of Nuclear Medicine, University College London Hopsitals NHS Trust, London, UK PubMed articles Google scholar articles
Rachael Hunter Research Dept of Primary Care and Population Health, University College London, London, UK PubMed articles Google scholar articles
Vincenzo Libri Leonard Wolfson Experimental Neurology Centre, National Hospital for Neurology & Neurosurgery, London, UKUniversity College London, London, UK PubMed articles Google scholar articles
Thomas Foltynie Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UKNational Hospital for Neurology and Neurosurgery, London, UK PubMed articles Google scholar articles

Correspondence to Professor Thomas Foltynie; t.foltynie{at}ucl.ac.uk

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Vijiaratnam N, Girges C, Auld G, et al

BMJ Open 2021;11:e047993. doi: 10.1136/bmjopen-2020-047993

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Received December 17, 2020
Accepted May 12, 2021
First published May 28, 2021.

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May 28, 2021

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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