Objectives To support the adaptation and translation of an evidence-based chronic kidney disease (CKD) self-management intervention to the Chinese context, we examined the beliefs, perceptions and needs of Chinese patients with CKD and healthcare professionals (HCPs) towards CKD self-management.
Design A basic interpretive, cross-sectional qualitative study comprising semistructured interviews and observations.
Setting One major tertiary referral hospital in Henan province, China.
Participants 11 adults with a diagnosis of CKD with CKD stages G1–G5 and 10 HCPs who worked in the Department of Nephrology.
Results Four themes emerged: (1) CKD illness perceptions, (2) understanding of and motivation towards CKD self-management, (3) current CKD practice and (4) barriers, (anticipated) facilitators and needs towards CKD self-management. Most patients and HCPs solely mentioned medical management of CKD, and self-management was largely unknown or misinterpreted as adherence to medical treatment. Also, the majority of patients only mentioned performing disease-specific acts of control and not, for instance, behaviour for coping with emotional problems. A paternalistic patient–HCP relationship was often present. Finally, the barriers, facilitators and needs towards CKD self-management were frequently related to knowledge and environmental context and resources.
Conclusions The limited understanding of CKD self-management, as observed, underlines the need for educational efforts on the use and benefits of self-management before intervention implementation. Also, specific characteristics and needs within the Chinese context need to guide the development or tailoring of CKD self-management interventions. Emphasis should be placed on role management and emotional coping skills, while self-management components should be tailored by addressing the existing paternalistic patient–HCP relationship. The use of electronic health innovations can be an essential facilitator for implementation.
- public health
- chronic renal failure
- qualitative research
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Strengths and limitations of this study
This is the first study to describe the beliefs, perceptions and needs towards self-management of chronic kidney disease (CKD) of patients and healthcare professionals in China.
The triangulation of data sources and framework method analysis optimised the internal validity and reliability of our results.
As our findings were not quantified, the relative importance of influencing factors (eg, paternalistic patient–healthcare professional relationships) for CKD self-management could not be determined.
The healthcare professionals who provided CKD care in the institution were predominantly female, and this group may not be representative of all healthcare professionals in nephrology practice.
Chronic kidney disease (CKD) is a severe public health problem.1 2 Globally, 697.5 million individuals have been affected by CKD.3 The burden of CKD is high in China, with an estimated prevalence of 10.8% (119.5 million adults).4 CKD is characterised by a gradual and irreversible loss of renal function and is categorised in five stages (CKD stages G1–G5) based on the estimated glomerular filtration rate (eGFR).5 Patients with CKD often report significant impairment in health-related quality of life6 and experience adverse health outcomes.7 Also, CKD imposes a substantial economic burden due to its considerable health-related and societal cost.8
Disease self-management (hereafter referred to as self-management) is vital to reducing disease burden and to controlling the healthcare expenditures for patients with chronic disease.9 10 As previously noted,11 self-management is composed of three main tasks: medical, emotional and role management. Hence, self-management is not limited to medical management but also aims to optimise the uptake of new meaningful behaviours or life roles, and it promotes adequate coping disease consequences.11 Appropriate self-management has the potential to optimise one’s ability to perform the cognitive, behavioural and emotional behaviour necessary to maintaining a satisfactory health-related quality of life.12 Also, for patients with CKD, self-management interventions may improve self-management behaviours13–15 and disease-specific knowledge,13 health-related quality of life16 and health outcomes,16 17 while it may also slow disease progression.9 18–20Despite these reported successes, many existing self-management interventions are prescriptive and deliver information without taking into account the patients’ understanding of self-management21 22 or the fact that self-management occurs in a social context.23 Patients’ needs for self-management support are not always known or met,24 and there is very little knowledge on how people with CKD would like to receive self-management interventions.25
Research on CKD self-management interventions has mostly focused on high-income countries, whereas the CKD burden is highest in low-income and middle-income countries.26 Hence, there is an urgent need for effective interventions that can decrease the CKD burden in countries with the fewest resources. One possible solution is to translate CKD self-management interventions that have been proven to be effective in high-resource settings to low-resource settings. However, applying a ‘one-size-fits-all’ approach is not sufficient as interventions cannot be simply translated as a whole to a different context. Instead, the target context should be explored along with the beliefs, perceptions and needs of the target population.27 To optimise chances of successful implementation, this information should then be used to make context-specific adaptations to the intervention and implementation strategies.28
To adapt and prepare an existing evidence-based CKD self-management intervention for implementation in China, we performed a qualitative study to examine the beliefs, perceptions and needs of patients with CKD and healthcare professionals (HCPs) towards CKD (self-management) in China.
The knowledge generated from this basic interpretive,29 cross-sectional qualitative study will inform the adaptation and evaluation of a tailored electronic health (eHealth) self-management intervention for patients with CKD in China based on the Dutch Medical Dashboard intervention.17 30 Details on the study protocol have been described elsewhere.31
Study setting and participant selection
This study took place within the First Affiliated Hospital of Zhengzhou University in the Henan province in China. Henan accounts for 9% of the rural Chinese population. An estimated 12 million or 16.4% of all adults in rural areas of Henan suffer from CKD.33 The Department of Nephrology of the hospital has approximately 276 beds, and more than 60 000 patients with CKD visit the outpatient clinic of this department each year.
Previous literature indicates that patients with CKD G1 or G2 report a multitude of symptoms and fairly high disease burden.34 35 Therefore, we anticipated that all patients with CKD (regardless of the CKD stage) have a great need for self-management interventions. Individuals eligible for inclusion were: (1) patients with a diagnosis of CKD with CKD stages G1–G5 and (2) HCPs who worked in the Department of Nephrology. Participants needed to be 18 years or older and speak Chinese. We followed the principles of ‘purposive and convenience sampling’36 to capture a diverse sample. Two sampling frames were used. The sampling frame for patients comprised the following variables: CKD stage, gender and age range. The sampling frame of HCPs comprised the variables: work experience, profession, gender and age. Also, we used snowball sampling37 to identify additional participants, in which current participants were asked if they knew any other individual who could participate in the study. For instance, participant AW knew another patient via WeChat who was severely ill and therefore did not visit the hospital often. This patient had not heard about the study. We asked participant AW to contact this patient and provide information on study participation. The patient then agreed to participate in our study. Study invitation strategies included: provision of flyers and face-to-face verbal invitations for both patients and HCPs and an online invitation for HCPs. All participants provided written informed consent to participation. Also, patients and HCPs received a reimbursement (20 RMB of telephone credit) for their time spent on the study.
One researcher (HS, Msc, female) conducted semistructured face-to-face interviews and observations (see online supplemental appendix 2) between January 2019 and April 2019. The interviewer had no prior contact with participants. The semistructured interview guide and observation forms were developed based on the FRESH AIR (Free Respiratory Evaluation and Smoke-exposure reduction by primary Health cAre Integrated gRoups) study,38 examples of similar studies39 and research team discussions (see online supplemental appendix 3). Also, the interview guide was theory driven as concepts of the Health Belief Model and the Theory of Planned Behavior were used to develop the topic list. A pilot interview was conducted with both a patient and an HCP to evaluate its content, length and understandability.
The interviewer was trained and had ample experience with qualitative research. To ensure confidentiality and privacy, face-to-face interviews were performed in a private room in the department. Also, the passive participant observations40 were conducted during patient outpatient clinic follow-up or during routine care visits. The behaviour by and conversation between patient and HCP were both observed. The observations were used to triangulate the interview data and to identify potential differences and similarities between what was said to happen when considering self-management behaviours (interviews) and what actually occurred in practice (observations). The sample size for the interviews and observations was not predetermined. Instead, the sample size was determined based on when data saturation was achieved, being the point at which no new or relevant information could be identified through the iterative, preliminary analysis of the data.41 All interviews were audiotaped digitally. After each interview, the interviewer made field notes detailing the interview setting, atmosphere and participants’ non-verbal behaviours. Additionally, we collected demographic and clinical characteristics of the participants from the patient medical records.
A Framework Method42 was used to guide our qualitative analysis.
Stages A and B: transcribing and familiarisation
All audio-taped interviews were anonymised and transcribed verbatim. Also, observation forms were digitalised and transported to Microsoft Excel 2010. Names and identifiers were removed to protect participant confidentiality. One researcher performed transcription and another researcher checked transcripts to ensure content accuracy. Before coding, each transcription was read as full text by the researchers in order to become familiar with the data set.
Stage C: development of an analytical framework and coding
Atlas.ti for Windows V.7.5.18 (Scientific Software Development, Berlin) was used for data analysis. We built initial coding trees based on the theoretical framework developed in our study protocol and the Theoretical Domains Framework (TDF).43 Three transcripts were coded using the initial tree. New codes that emerged were added to the tree. After discussion among the research team, a final coding tree was agreed on. Then, one researcher coded all transcripts and observation forms using the final coding tree. The assigned codes were verified by a second researcher (WW).
Stage D: charting data into the framework matrix
Data were further reduced by formulating within-cases and cross-cases.44 Next, data were charted into matrices per research question using Microsoft Excel 2010 and reviewed by all authors. The matrix comprised one row per participant and one column per code.
Stage E: interpreting the data
Themes were generated from codes derived from the data set by reviewing the matrix and making connections within and between participants and codes. Emergent themes were then organised into major themes and subthemes. All themes were discussed among the research team and modified if needed. Also, the results of participant observation were triangulated with face-to-face interview analysis.
Establishing rigour in the data collection and analysis process
Rigour in data collection and analysis, by ensuring credibility, confirmability, dependability, transferability and authenticity, was achieved in the following ways.45 Two team members most closely involved in the fieldwork (HS and WW) met frequently to discuss the constancy of the data collection process and (preliminary) analysis. At regular intervals, meetings were held with members of the wider research team with extensive qualitative (RMJJvdK) and clinical (PJMvdB) experience to discuss codes and categories emerging from the analysis. Also, the framework approach to data analysis allowed data to be compared through the formulation of narratives (in-depth focus) and within-case and cross-case comparisons (comparative focus). Additionally, during data analysis, the two fieldwork researchers kept a research diary and made reflective notes.
The research group was multidisciplinary as it included researchers, clinicians, nurses and academics from both China and the Netherlands. The diverse disciplinary backgrounds, research experiences and positions of the members of this group stimulated the collection and analysis of rich data, as each member held different perspectives, which were shared and debated during research meetings. As the management of CKD is very different in the Netherlands compared with China, all members reflected on their own experiences with CKD (self-)management and how these might have affected the performance of their research tasks. Moreover, during research meetings, all members reflected on the professional lens through which they observed the phenomenon of interest and how this might have impacted their research tasks.
Patient and public involvement
Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research.
Participant and interview characteristics
A total of 21 face-to-face interviews and 26 observations were conducted (tables 1 and 2). Out of 15 approached patients, 11 patients (73%) agreed to participate in the interview study. Out of 11 approached HCPs, 10 (91%) HCPs agreed. Reasons for refusal to participate included a lack of time due to patients’ extended waiting time for a physician consultation or intravenous infusion or lack of interest in the research presented. Reasons reported by HCPs included a lack of time due to work obligations (see online supplemental appendix 4 for interview characteristics). No significant differences were observed between the final sample and those who refused to participate.
Four major themes emerged for both patients and HCPs. These themes and respective subthemes are described in the following sections with reference to the relevant quotes (see tables 3 and 4, online supplemental appendix 5).
Theme 1: CKD illness perceptions
CKD diagnosis and anticipated consequences of illness (patient generated)
More than half of patients mentioned that they had a ‘late’ CKD diagnosis and attributed this to their limited awareness and recognition of CKD symptoms (table 3, Q1). Patients with CKD mentioned initial difficulties in understanding and accepting their CKD diagnosis (table 3, Q2), as they felt fearful and uncertain about the permanence of CKD, its influence on their future health (table 3, Q3) and the anticipated social and financial burden (table 3, Q4).
Physical, psychosocial and lifestyle consequences of CKD (patient and HCP generated)
Patients frequently mentioned that they felt ‘discomfort’ and ‘weakness’ because of symptoms such as fatigue (table 3, Q5), especially those with CKD stages G4–G5 (table 3, Q6). Also, both patients and HCPs highlighted the psychosocial impact of CKD. Patients expressed frustration and depression due to their deteriorating health status and impairments in their social life (table 3, Q7). Also, patients mentioned losing their job and facing difficulties in re-entering the workforce as a consequence of CKD, making them feel anxious about their financial situation (table 3, Q8). Additionally, they felt guilt and regret about the burden their disease imposed on family members (table 3, Q9). All these impacts were also observed in the consultations (see online supplemental appendix 5).
More than half of patients mentioned that CKD treatment requirements made them feel that they were not living a ‘normal life’ (table 3, Q10). Also, patients receiving dialysis mentioned that their daily treatment schedule led to difficulties in travelling and engaging in social activities (table 3, Q11).
Theme 2: understanding of and motivation towards CKD self-management
Understanding of CKD self-management (patient and HCP generated)
Patients and HCPs both mentioned that they considered CKD self-management to be solely ‘medical management’. However, how they expressed this understanding differed significantly (table 3).
More than half of patients and HCPs described CKD self-management as ‘adherence to medical advice and treatment as prescribed’ (table 3, Q15). Patients also described CKD self-management as ‘being obedient’, literally quoting their HCPs’ medical advice (table 3, Q12–14). Also, HCPs expressed that improving patient disease knowledge as the priority of CKD self-management (table 3, Q16).
Motivation towards CKD self-management (patient and HCP generated)
Patients expressed the belief that self-management could slow down their disease progression and optimise their health status (table 3, Q17). More than half of HCPs considered CKD self-management as a necessity to control patients’ symptoms and for improving health-related outcomes (table 3, Q18).
Patients believed that HCPs were sufficiently knowledgeable to help them manage their disease (table 3, Q19) and named their own responsibilities within CKD self-management as ‘strictly following medical advice’ (table 3, Q20). HCPs frequently expressed that their role in self-management was to inform patients about the importance of adherence to medical advice and enable this adherence by providing health education (table 3, Q21).
Theme 3: current CKD practice
Theme 3a: current self-management practice by patients (patient generated)
When asked about their current CKD self-management, patients mostly named concepts related to medical management, such as disease-specific controlling behaviours (DCBs). The most frequently mentioned DCBs were: adhering to medical advice on medication use (table 4, Q22), treatment and regular follow-up, self-monitoring (table 4, Q23) and symptom management (table 4, Q24). Additionally, more than half of the patients mentioned the performance of healthy behaviour, such as diet restrictions (table 4, Q25). The discussion of patients’ DCBs was frequently observed in consultations (see online supplemental appendix 5). Other aspects of self-management, such as role and emotional management, were not frequently mentioned. Some patients described a shift towards a more passive ‘patient role’ (table 4, Q26). Two patients mentioned the experience of coping with emotional problems (table 4, Q27–28).
Patients frequently named the use of problem-solving and decision-making skills when experiencing physical symptoms (table 4, Q29). Patients searched and obtained disease-related knowledge from various sources including their HCPs, the internet, hospital brochures and contact with other patients (table 4, Q30–31). These findings were consistent with observation data (see online supplemental appendix 5). Other aspects of CKD self-management skills, such as partnering with their HCPs and action planning based on goal setting, were not frequently mentioned. Some patients mentioned that HCPs provided advice on how to cope with symptoms (table 4, Q32) or stated to have created and modified self-management action plans (table 4, Q33).
Theme 3b: implementation of self-management intervention by HCPs (HCP generated)
HCPs mentioned facilitating patients’ self-management by providing health education, especially about strict adherence to medical treatment (table 4, Q34). Observations confirmed that CKD-specific health education was frequently provided by HCPs (see online supplemental appendix 5).
Theme 4: barriers, (anticipated) facilitators and needs towards CKD self-management
Patients and HCPs frequently named a lack of knowledge of CKD (eg, symptoms) and difficulties in making necessary lifestyle changes as barriers to patients’ self-management outcomes (table 4, Q35). Moreover, patients and HCPs frequently mentioned barriers related to the environmental context and resources, such as limited (online) education resources and HCPs’ time constraints (table 4, Q36–37). Barriers for patients related to ‘social influence’ were named by HCPs, such as inadequate support from family members (table 4, Q38). Also, HCPs stated that they felt patients’ emotional problems interfered with the patient–HCP communication, impeding patients’ self-management (table 4, Q39).
(anticipated) Facilitators and needs
Patients and HCPs commonly mentioned that sufficient disease-related knowledge might support patients’ adherence to treatment and improve self-management skills (table 4, Q40). Also, patients and HCPs emphasised that access to trustworthy (online) educational resources might facilitate self-management efforts (table 4, Q41). Additionally, patients and HCPs cited adequate family-level support and effective patients–HCP communication as facilitators (table 4, Q42–43). Needs reflected the anticipated facilitators: patients and HCPs expressed the need for better access to and provision of disease-related knowledge (table 4, Q44), especially through eHealth mediums (table 4, Q45).
The beliefs, perceptions and needs of patients with CKD and HCPs regarding CKD self-management were examined. Our study revealed that almost all patients and HCPs solely mention the medical management of CKD: self-management is largely unknown or misinterpreted as adherence to medical treatment. Also, both patients and HCPs mentioned heavy psychosocial impact resulting from CKD. Furthermore, we found that a paternalistic patient–HCP relationship was often present.
Our finding that self-management is often misinterpreted as adherence to medical treatment underlines the importance of education on the core concepts and possible advantages of self-management interventions. Self-management is comprised of medical, emotional and role management,11 and it aims to optimise the uptake of meaningful behaviours or life roles, promoting adequate coping with disease consequences.11 Hence, if patients and HCPs do not fully understand the concept of self-management, this might influence their uptake of self-management interventions in practice.47 48 A recent review examined the effectivity of interventions to educate professionals on how to support patient self-management through eHealth.49 For example, blended learning that combines e-learning and face-to-face methods is suggested to support self-management skills development for HCPs.49 Also, improving health literacy, namely the ability to access, process, comprehend, use health information and to effectively communicate with HCPs about health information, has been associated with successful disease self-management of patients with CKD.50 An intervention that focusses on education about self-management and aims to improve health literacy may improve the chances of successful uptake of self-management behaviours.
Patients almost never mentioned the psychosocial aspects of self-management, but they did mention the heavy psychosocial impact resulting from CKD. Considering this contradiction, we advise future research and developers in China to increase their focus on the psychosocial aspects of CKD and to contemplate the use of cognitive–behavioural therapy elements51 to help manage this impact. Also, patients’ self-efficacy and ultimately their self-management health behaviours52–54 are associated with psychosocial well-being, making an increased focus on the psychosocial aspects of the disease as a prerequisite for successful disease self-management in general.
Consistent with previous literature,55 patients with CKD stages G4–G5 in our study frequently mentioned a heavy symptom burden. However, these patients did not express a greater need for self-management interventions, as we would expect from previous research.55 This may be explained by the fact that patients cannot ask for things they do not know: patients’ misinterpretation of self-management may have limited their ability to express their needs. Also, as patients with CKD G4 or G5 have often suffered from the disease for a long period, they may have adapted to living with their disease and therefore feel less need for self-management interventions.
Patient autonomy is a core principle of the patient–doctor interaction in Western cultures.56 57 However, under certain conditions, the paternalistic relationship we encountered in our study can be valuable and even essential to improving health outcomes and treatment adherence in some cultural contexts, for instance, if patients prefer a paternalistic approach over autonomy.58 59 We advise not to try and eliminate this paternalistic relationship but to incorporate its potentially positive aspects in self-management interventions. Also, improving patient activation has been an important factor for successful self-management and should be fostered.60 61 Previous literature has showed that a higher level of patient activation is associated with higher levels of self-care in patients with CKD.61 Hence, we argue that it is important to focus on and improve patient activation before implementing self-management intervention, especially considering the current dominant patient–HCP relationship. For example, an intervention can be developed by building patients’ skills in posing more and better questions to their doctors and in recognising the importance of asking questions in the decision-making process.62 Additionally, increasing patients’ empowerment can be an effective way to facilitate shared decision making. A more individualised and specialised empowerment intervention is needed,63 for instance, by providing patients with tailored education and psychosocial support including a focus on self-confidence. Such an intervention can increase patients’ awareness of self-management behaviours and strengthen their ability to successfully manage their disease and life.
A barrier to adequate self-management that was frequently reported by patients is a lack of knowledge. We found that the use of eHealth was largely supported by patients and HCPs to address this barrier. As such, we advocate the development of a national, trustworthy health education resource platform to address the needs expressed by patients for access to reliable medical information. As an example, an evidence-based health information website (http://www.thuisarts.nl) in the Netherlands has effectively improved self-management and reduced healthcare usage.64 However, previous literature showed that only increasing patients’ knowledge was insufficient to modify their behaviour.65 Thus, we highlight the importance of also improving both patients’ motivation and their behavioural skills to facilitate their CKD self-management. As an example, serious gaming has the potential to improve patients’ motivation and behaviours of self-management. China has numerous internet and mobile phone users,66 and serious gaming is cost-effective, flexible, portable and could invoke intense and durable interest among patients and HCPs in engaging in regular self-management (implementation).67
To our knowledge, this is the first study to describe the beliefs, perceptions and needs towards CKD self-management of patients and HCPs in China. We performed an exploratory, cross-sectional study taking a basic interpretive (generic) qualitative research approach.29 We argue that this approach is most suitable for examining the individual beliefs, perceptions and needs towards CKD self-management, as it allows us to provide a low-inference description of the phenomenon of interest, allows us to combine inductive and deductive reasoning while building on the existing knowledge base on this topic mostly derived from research performed in western countries. We also considered taking a phenomenological approach. However, we were not primarily interested in the inner dimensions or essence of the concepts and processes that we investigated. Instead, we were interested in the participants’ interpretation of the beliefs, perceptions and needs themselves. In other words, we wanted to know what patients believed and not necessarily how these beliefs came to be. Grounded theory was not an option, as we did not aim to build a theory from scratch explaining (the interaction between) these concepts (like one would when applying a grounded theory approach). As we are aware of the pitfalls of generic qualitative research,68 69 we therefore adhere to the ‘big-tent’ criteria for excellent qualitative research. Tracy et al70 suggest that when designing qualitative research, developers should focus on the ‘ends’ rather than getting stuck in methodology-bound ‘means’. Also, we follow the guidance provided on how to perform and report on generic qualitative research68 69 to optimise the quality and the validity of the results. Moreover, the framework method for data analysis is consistent with our research design, as it is not aligned with a particular epistemological, philosophical or theoretical approach to qualitative research. Instead, it can be (adapted) for use in different approaches that aim to examine specific topics or themes.71 It is furthermore especially suitable for multidisciplinary health research that includes both patients and HCPs.42 The framework method can be used for both inductive and deductive coding to understand the phenomenon of interest. In our study, we expand and falsify existing knowledge on beliefs, perceptions and needs about CKD. We thus need to combine the inductive and deductive aspects of coding, making the framework method an excellent match. By using the framework approach, we clearly and systematically detail the steps performed as well as the perspective taken on the data collection and the analysis process, hence preventing ‘method slurring’.72 Additionally, other strategies to optimise quality and the validity of the results were adopted. As our study includes the triangulation of data sources, rigour was established in the data collection and analysis process.
Nevertheless, there are also limitations. First, as our findings were not quantified, the relative importance of influencing factors (eg, paternalistic patient–HCP relationship) for CKD self-management could not be determined. Second, the HCPs who provided CKD care in the institution were predominantly female. The HCP group interviewed was not representative of all HCPs in nephrology practice. This selection bias might be caused by the fact that participants who were more positive towards self-management were more likely to participate in our study. However, the number of negative experiences and barriers identified in this study might indicate that this bias has remained limited. Due to time restrictions, participants were not asked to provide feedback on the transcripts and results. However, during the interviews, the interviewer often summarised her interpretation of participants’ answers in order to receive clarifications and confirmation.
This study provides a comprehensive overview of patients’ and HCPs’ beliefs, perceptions and needs towards CKD self-management in China. To optimise the implementation of self-management interventions, future developers should be mindful of the limited understanding of CKD self-management and prepare their interventions accordingly. Also, considering the heavy psychosocial impact of CKD, the focus of self-management interventions should be put on enhancing patients’ role management and emotional skills. We advise developing intervention components tailored to the specific cultural context to improve CKD self-management implementation in developing countries. With this approach, selected self-management intervention elements can be implemented using eHealth mediums.
The authors would like to thank all the research participants who provided their valuable time to share their experiences. Also, we would like to acknowledge researchers Jie Chen and Shuchen Wang in the First Affiliated Hospital of Zhengzhou University for their support in organising the research. This work has not been presented at a conference/published as a conference abstract.
Contributors HS led the design of this study and is the main contributor in writing this manuscript, with contributions from all authors. HS and WW participated in data collection and analysis. RMJJvdK, PJMvdB, XS, ZL, XL and and NC contributed to the design of the study and editing of this manuscript. All authors read and approved the final manuscript.
Funding This work was supported by the China Scholarship Council (CSC) (grant number 201707040096).
Competing interests None declared.
Patient consent for publication Not required.
Ethics approval This study was approved by the Ethics Committee of the First Affiliated Hospital of Zhengzhou University (reference number 2019-KY-52).
Provenance and peer review Not commissioned; externally peer reviewed.
Data availability statement Data are available on reasonable request.
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