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Association between asthma and dry eye disease: a meta-analysis based on observational studies
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  • Published on:
    Possible patient overlap in the meta-analysis
    • Yung-Chieh Huang, Pediatric Immunologist and Nephrologist Department of Pediatrics, Taichung Veterans General Hospital, Taichung, Taiwan

    Dear Editor,
    I just read the research “Association between asthma and dry eye disease: a meta-analysis based on observational studies” written by Q Huang and colleagues. I appreciated their work about connecting and analyzing the association between the two diseases, and raising awareness for physicians in clinical practice.

    However, I have some concerns about the analysis process in this research. Among the six studies included in this meta-analysis, two studies [2,3] used data from NHIRD of Taiwan. In the study conducted by colleagues and me (as the first author), [2] we analyzed in the aspect of the immunologists. We retrospectively included the patients with and without the diagnosis of asthma between 1998-2010 in NHIRD. We found that patients with asthma were associated with dry eye disease (DED), and there were some risk factors, including females, comorbidities such as allergic rhinitis and urticaria, and prescriptions including LTRAs, antihistamines, and inhaled corticosteroids. In the study conducted by Wang and colleagues, [3] they investigated the comorbidities that patients with DED may have, in the aspect of the ophthalmologists. They retrospectively included patients with DED between 2005 to 2006. The authors found that patients with DED were more likely to have multiple comorbidities, including asthma.

    NHIRD is a representative database that included one million randomly sampled patients from all NHI enrollees. The database is for resear...

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    Conflict of Interest:
    I am the first author of the study, Association between dry eye disease and asthma: a nationwide population-based study, cited a an reference in this meta-analysis.