Objectives In COVID-19, transfer of respiratory materials transmits disease and drives the pandemic but the interplay of droplet and aerosol physics, physiology and environment is not fully understood. To advance understanding of disease transmission mechanisms and to find novel exposure minimisation strategies, we studied cough-driven material transport modes and the efficacy of control strategies.
Design Computer simulations and real-world experiments were used for integrating an intensive care setting, multiphysics and physiology. Patient-focused airflow management and air purification strategies were examined computationally and validated by submicron particle exhalation imaging in volunteers.
Setting Hospital setting during a respiratory virus pandemic with transmission by respiratory droplets and aerosols.
Participants Healthy volunteers.
Outcome measures Distribution of, and exposure to, potentially infectious respiratory secretions.
Results Respiratory materials ejected by cough exhibited four transport modes: long-distance ballistic, short-distance ballistic, ‘jet rider’ and aerosol modes. Interaction with air conditioning driven flow contaminated a hospital room rapidly. Different than large droplets or aerosols, jet rider droplets travelled with the turbulent air jet initially, but fell out at a distance, were not well eliminated by air conditioning and exposed bystanders at larger distance and longer time; their size predisposes them to preferential capture in the nasal mucosa, the primordial COVID-19 infection site. ‘Cough shields’ captured large droplets but induced lateral dispersion of aerosols and jet riders. An air purification device alone had limited efficacy. A ‘Shield and Sink’ approach combining cough shields with ‘virus sinks’ minimised exposure to all secretions in modelling and real-life experiments.
Conclusions Jet riders have characteristics of highly efficient respiratory infection vectors and may play a role in COVID-19 transmission. Exposure to all droplet types can be minimised through an easily implemented Shield and Sink strategy.
- infection control
- respiratory infections
Data availability statement
Data are available upon reasonable request.
This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
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Strengths and limitations of this study
A key strength of this study is the use of a methodology that is directly, rapidly and inexpensively translatable to clinical practice for mitigation and control of the COVID-19 pandemic.
Another key strength is the combination of computer modelling and real-world experiments, supporting each other and lending credibility to the proposed novel disease transmission strategy.
Another key strength is the embedding of simulation and experiments in a hospital and intensive care unit setting, supporting relevance to specific settings, while the findings are generalisable to other settings and infectious agents.
A limitation is that the relative contribution of various droplet sizes to real-world infection transmission is still unknown, although this does not limit the applicability of the study findings.
Another limitation is that clinical outcomes, namely infection transmission rates in large patient cohorts over prolonged time in real-world application have not yet been studied.
Role of droplets and aerosols in coronavirus transmission
Droplet transmission from coughing or sneezing is considered the dominant mode in COVID-19 but current evidence also suggests a role of aerosol-mediated virus transmission1 2 rendering understanding and control of emitted respiratory materials of all sizes desirable. Arguments for a role of aerosols include transmission by asymptomatic persons,3–5 epidemiological observations in SARS-CoV-2,6–8 air sample analysis,9 10 in SARS- SARS-COV-211 and SARS-COV-1,12 and general observations in virus and bacterial aerosol transmission.13–15 Controlling aerosol transmission may be an adjunct to avoiding droplet transmission for COVID-19 control16 17 as recently emphasised by many experts.18 19
Expiratory droplets, aerosols and submicron particles: physiological origin, physical aspects, room distribution and persistence
Droplets of various sizes are produced when air moves across wet respiratory surfaces during respiring, coughing, sneezing, talking or singing. Droplet number and size mix depend on activity and will influence weight and infectious agent content; also, droplet motion20 is size dependent, ranging from ballistic transfer to slip flow to free molecular flow. The multiphase air jets in coughing or sneezing contain various droplet sizes; in small droplets termed aerosols, aerodynamic drag dominates gravity, such that they tend to travel with the air rather than to falling to the ground; in contrast, larger droplets move ballistically due to larger mass and stronger gravitational impact and may transition to smaller aerosol particles on water evaporation. Understanding the spectrum of droplet and aerosol-mediated disease transmission therefore needs consideration of production, initial acceleration, droplet/aerosol characteristics and behaviour of the environment-like air motion. While the traditional medical categorisation of droplets versus aerosols with an empiric cut-off of 5–10 um in medical literature is disputable21 and rather represents a continuum, examining size-dependent behaviour nevertheless may elucidate differences in transport modes important for transmission prevention.
Real-life imaging of droplets and aerosols produced by coughing and respiration is possible22–25 but methods have practical limitations. E-cigarette smoke has submicron particle size comparable to respiratory aerosol subpopulations26 27 and is accessible to imaging, so that E-cigarette smoke tracking might enhance understanding aerosol clouds and allow validating theoretical predictions.
Source control and personal protective equipment
Minimising the risk of infection transmission can be achieved by a hierarchical approach including elimination of infectious material release (source control), engineering controls (eg, increasing ventilation), administrative controls and personal protective equipment (PPE). The current emphasis in COVID-19 transmission control is on social distancing, testing, isolation of affected individuals and their contacts, use of PPE and vaccination of involved personnel. In a hospital environment, PPE like masks and gowns confer significant protection, but the relevance asymptomatic and presymptomatic transmission and the phenomenon of super spreaders would call for broad use of PPEs, and if not worn to the full extent, may lead to partial protection only. Improved source control might contribute to transmission risk reduction particularly in settings where widespread use of full PPE is not feasible.
Aim of the study
We aimed at in-depth understanding of transmission of potentially infectious secretions from coughing persons to their environment in a hospital context, based on cough physiology, real-life room architecture and air conditioning. Using computational and real-life experiments, we further aimed at developing effective source control measures that minimise transfer of such materials and may thus minimise indoor COVID-19 transmission risk.
Methods include modelling of room architecture, air flow and cough physiology combined with real-world experiments in a hospital setting.
Hospital rooms involved in COVID-19 patient care in the University Hospital Basel, Switzerland, were recreated as volumetric digital models, equipped with patient beds, monitors, desks, air conditioning system, cough shields and air sinks.
Air flow modelling
A computational multiphysics model was based on room geometry and standard fluid dynamics modelling of air flow, based on the hydrodynamic principles described by Bernoulli at our university in 1738,28 formalised as Navier-Stokes equations and implemented as an open-source computer library, as described in the online supplemental material 1. Modelling included pressure, flow, aerosol content, temperature and buoyancy. Room ventilation was parameterised according to the existing air conditioning system (25°C, 30% humidity), with site-typical baseline air flow settings at four room air exchanges per hour (~800 m3/hour) and exploratory settings from minimum regulatory recommendations for Intensive Care Unit (ICU) rooms (>40 m3/hour/person+100 m3/hour/patient29 30) up to 10 room air exchanges per hour for a given room. Patient airflow was modelled as air emanating from the mouth of a patient in a semirecumbent bed position (ie, cough jet direction upwards with 30° forward tilt) and optional lateral head rotation. Normal respiration and biphasic flow patterns31 for cough were modelled, with ‘exhalation’, ‘weak cough’ and ‘strong cough’ modelled as peak airflow velocities of 1.5, 10 and 20 m/s, respectively. A ‘breathable zone’ (typical caregiver head location) was defined from 1/3 to 2/3 of room height, with particle density in this zone as surrogate for caregiver exposure, while particles sticking to surfaces or floating near the floor or the ceiling were considered ‘not breathable’.
Droplet and aerosol modelling
Modelling of droplet and aerosol distribution and dynamics was done in two complementary ways: particle modelling and diffusion modelling.
In particle modelling, individual droplets and aerosols were modelled as spheres moving in the air flow that was modelled by fluid dynamics. Physical particle modelling included starting point, ejection velocity at mouth level, ejection angle, aerodynamic drag exerted by the surrounding moving air, including gravitation, random effects and Brownian motion. Droplets were generated in numbers proportional to orifice velocity, in size clusters with mean diameters of 1 mm, 100 µm, 10 µm, 1 µm and 0.1 µm±20%, corresponding to observed droplet sizes in cough32 and sneezes, down the size of a single virus particle. Terminal velocity for each droplet due to gravity was determined as a function of the Reynolds number. Dynamics for each droplet within the fluid dynamics field were modelled, using both, separate runs for each size cluster as well as combined runs to understand differential distribution and fate of droplets. Droplet impact on surfaces led to sticking of the particle to said surface. Droplets sticking to a surface or exiting the room through exhaust pipes or door were counted.
In a convection/diffusion model, complementary to the particle analysis, air contamination by aerosols was modelled as continuous diffusion model, as described in more detail in the online supplemental material 1, with origin of the solute at the mouth, using particle size to compute the diffusion coefficient.
‘Virus Shield and Sink’
Virus shields consisted of bed-mountable transparent polycarbonate plates of size 45 cm×35 cm to 60 cm×60 cm, with their corresponding digital model, positioned in front of the patient’s head and angulated such that the dominant cough direction hits the shield approximately in right angle. A ‘Virus sink’ consisted of a commercial air purifier device (Toom Model 30W, REWE Zentral AG, Köln, Germany) having an air inlet diameter of 32 cm, a HEPA (high-efficiency particulate air) filter, was capable of purifying up to 350 m3/hour, and its corresponding digital model, having H13 Hepa filter characteristics, positioned at the cranial bed end, with the air inlet near the patient head. In modelling and real-world experiments, the per-patient air purifier was driven at its nominal output of 350 m3/hour (ie, increasing total equivalent room air exchange by 50% from baseline).
Real-life imaging of submicron particle distribution on coughing
Two habitual E-cigarette smokers were positioned in an ICU bed in the modelled room, instructed to inhale the smoke of their E-cigarette and then to voluntarily cough with moderate strength, and were filmed for digital submicron particle imaging without and with the ‘Shield and Sink’ equipment in different combinations.
Patient and public involvement
The study was triggered by discussions between physicians and ICU nurses on strategies to minimise in-hospital virus transmission during the ongoing COVID-19 pandemic.
Modelling: room geometry and ventilation
Room geometry, room installation and air flow due to the air conditioning system (A/C) using standard A/C settings are shown in figure 1. A downdraft near the patient’s leg location from the A/C inflow to the outlet vents near the door drives a horizontal air motion component even in stationary flow conditions. Flow showed the expected vortex ring formation at the inlets, and was otherwise almost stationary (compatible with the Reynolds number up to 2000) in standard A/C settings but changed to an oscillating pattern with increased turbulence at 10 room air exchanges per hour a predicted by the Reynolds number ~5000 (indicating a turbulent regime).
Distribution of ejected droplets and aerosols in modelling
As shown in figure 2 and online supplemental movie 1, four characteristic dynamic behaviours were documented: In the first seconds of a cough, ballistic ejection of 1 mm droplets up to 4 and 6 m distance during moderate and strong coughs was observed in the particle model, capable to reach the contralateral wall, nurse workplaces and adjacent beds, depending on head rotation. Notably, the upward/forward direction of the cough jet due to the semirecumbent patient position essentially doubled the reach of ballistic droplets compared with a horizontal jet direction. Droplets in the 0.1 mm size range started ballistically but were quickly slowed down by aerodynamic drag and, attracted by gravity, fell down within 1 m around the patient head, such that after the first 3 s, most droplets from 1 to 0.1 mm had hit a surface and were no longer in the air. Droplets in the 10 µm size range behaved differently: due to the small size and a high drag/gravity force ratio, they travelled with the air jet for several metres before falling out due to gravity from the slowed down air convection; distance travelled by these droplets even surpassed most large ballistic droplets; they were the main population sprayed on a neighbour bed in a specific setting. The fourth population with droplets of size 1 µm down to 0.1 µm, showed classical aerosol behaviour and travelled throughout with the air convection, not falling out at the studied range of ventilation settings. Such aerosols followed complex trajectories within the room determined by A/C induced air flow patterns, and depending on cough direction and ventilation settings, reached most room locations within a few minutes, before being removed by exiting through the ventilation exhaust, sticking to a wall, or, with the door opened, by leaving through the door to central ICU workplaces.
Formation of complex air flow patterns was observed in particular at higher A/C setting, with air mixing and recirculation driven by vortex formation, caused by the finite-sized A/C inlets (online supplemental movie 2). The convection–diffusion model yielded complementary results consistent with the aerosol particle modelling and showed that within minutes, in most locations of the room (except downstream of the air conditioning inlet), concentration of aerosols builds up and is only slowly cleared (10–20 min) by air conditioning, implying that a higher cough frequency leads to accumulation of aerosols.
Exposure to various droplet fractions at ‘breathable locations’ over time
The time course of particles in the breathable zone of the room is shown in figure 3. Larger droplets were quickly sprayed across space but had all but disappeared from the air at 3 s, either sticking at walls, floor or beds. Aerosols in the 0.1–1 µm range persisted for 20 min in significant proportion in the breathable zone and showed recirculation, but due to their propensity to rise towards the ceiling through the buoyancy of the warm exhaled air (where the air conditioning exhaust is located), exposure in the breathable zone was lower for small aerosols than for ‘jet riders’ (droplets in the 5–40 µm size range) that dominated the breathable zone air up to 300 s and resulted in large exposure-time integrals, a surrogate for exposure intensity.
Droplet and aerosol capture strategies in model
As shown in figure 4 and online supplemental movie 3, Virus shields positioned in front of the patient could captured all large droplets with trajectories suited to reach distant locations. However, air jet splitting and redirection was observed with such shield, leading to lateral aerosol plumes moving in direction of nurse workplaces and the adjacent patient bed.
A virus sink/air filtration device positioned near the patient’s head and driven at nominal performance (350 m3/hour) was neither capable to capture the larger droplets nor the majority of the aerosol produced, because the jet emanating from the mouth was sufficiently fast and strong to overcome the small air flow velocity field produced by the device. The supplemental figure (online supplemental material 2) shows droplet and aerosol dispersion with the various scenarios in more detail.
In the novel Shield & Sink strategy, a shield and a sink run at its nominal output were combined based on parameters identified in modelling. Modelling showed that at sufficient sink air flows, the shield bends the streamlines of the cough air flow such to keep the aerosol plume in proximity to the sink device, so that it can be quantitatively captured and filtered by the device. Stepping up from a H13 to a higher performant H14 Hepa filter had a negligible additional effect on the results, but higher cough jet velocities increased the proportion of ‘escaping’ aerosol while higher air sink velocity decreased it (data not shown). The added value of air disinfection strategies, for example, by ultraviolet light was not examined but the results suggest that its potential for incremental benefit to Shield & Sink is small.
Droplet and aerosol capture strategies in real-life scenario
Findings are shown in figure 5, online supplemental movie 4 and 5. Assessing the behaviour of emitted submicrometre particles by digital submicron particle imaging of ejected E-cigarette smoke confirmed computational predictions: coughing rapidly produced a large particle plume, discernibly by eye up to 2 m in the first seconds, followed by slow further movement. Installing a shield in front of the face led to jet splitting and redirection. Using an air filtration device near the patient’s head was incapable to quantitatively remove the aerosol. However, in the Shield and Sink strategy, the shield slowed the aerosol jet such that the plume was aspirated and filtered to a visually full degree by the sink device. The online supplemental movie 3 and 4 demonstrate the performance of droplet and aerosol capture strategies in modelled and real-life scenarios.
The ‘Graphical Abstract’ summarises the findings by visualising cough-triggered dispersion of respiratory secretions of different sizes in a hospital room with air conditioning, and effective source control against dispersion by ‘Shield & Sink’ strategy.
In the context of the ongoing COVID-19 pandemic, this study analyses the spread of potentially infectious materials produced by respiratory events like coughing and examines the value of source-control measures for avoiding droplet and aerosol transmission of respiratory materials to bystanders during hospital care of patients. It quantitatively analyses distribution, recirculation and out-of-room transfer of droplets and aerosol produced by coughing and breathing through computational modelling of patient activity, room architecture and air conditioning and validates the findings by exhaled particle cloud imaging. Extending prior simulation findings on coughing and airborne droplet transmission,33 it describes four different and potentially medically relevant modes of droplet transport: (1) dominant ballistic (long distance fallout), (2) ballistic-drag (short distance fallout), (3) floating-gravity dominated (longest distance fallout, ‘Jet Riders’) and (4) fully floating (no fallout) . While these categories are context dependent, they nevertheless may contribute to qualitative understanding and intuition for protection strategies in specific settings. The findings extend earlier work on the relevance of low-velocity directional flow in indoor conditions for infection propagation.34 The main results are graphically summarised in the graphical abstract (online supplemental material 3).
The novel Shield and Sink approach introduced here is a patient-centred strategy to transmission avoidance by creating per-patient aerodynamic settings, an approach that proves highly effective and achieves near-complete elimination of droplets and aerosol of all classes near the patient head in modelling and real-world experiments, suggesting a potential for strongly reducing exposure of care persons and nearby patients.
The quest for source control measures to stop infection propagation
In view of the persistence35 of SARS-CoV2 in aerosols with an estimated half-life of 60 min, PPE for minimising droplet and aerosol inhalation is widely used in direct COVID-19 patient care. However, the occurrence of asymptomatic carriers and superspreaders renders each untested patient entering a hospital a potential source of infection. Rapid testing of each patient and use of full PPE for each untested individual may not be realistic and economically feasible in all settings at a global scale, raising the question if, and to what degree, suited source-control measures could prevent transmission of infectious material to caregivers, other patients and other bystanders.
Determinants of droplet and aerosol propagation
We found that the spread of potentially infectious material from the airways to the environment is highly variable and determined by patient characteristics (coughing strength, head position), droplet size, room geometry and ventilation conditions. Even in ventilation conditions fulfilling current hospital architecture norms, droplet spread reached neighbour patients and nurse workplaces; prolonged aerosol circulation was observed, but increasing ventilation settings was found to potentially increasing room air turbulence, that is, undesired air mixing, visualised in online supplemental movie 2.
For droplets in the 1 mm range, we observed ballistic transfer up to 5–6 m in strong and 4 m in moderate strength cough jets. The longer reach of droplets compared with the historical 1–2 m rule for droplet transmission has several reasons: first, in ICU and hospital room patients, the frequently used semirecumbent position36 with head elevation ≥30° directs the cough jet obliquely upwards and thereby maximises a ballistic trajectory; also, such droplets initially travel with the air jet (ie, less drag), benefit from upward buoyancy of the warm expired air, and dry up slower due to the expired air humidity, enabling them to reach farther than an isolated water droplet horizontally emitted into non-moving dry air. Droplets in the 0.1 mm diameter range also behaved ballistically, but their smaller kinetic energy led to quick slowdown by drag as soon as they left the cough air jet, and being pulled down by gravity, their reach was limited to approximately 1 m around the head.
Typical aerosol behaviour (travelling with the surrounding air, flowing around obstacles) was observed for droplets starting at the 1 µm down to the 0.1 µm ranges, consistent with literature; the negligible impact of gravity on such very small droplet combined with the higher temperature of the exhaled air explained their tendency to rise towards the ceiling and being eliminated through the air conditioning exhaust. Jet rider droplets, smaller than ballistic droplets but larger than classical aerosols, appeared to have particular importance:
‘Jet Riders’ with distant fallout
Notably, the size fraction of droplets in the 10–20 (or 5–40) µm range displayed a behaviour that does neither fit in the ‘ballistic’ nor in the ‘aerosol-type’ patterns: While it travels in the early, fast, warm, turbulent and buoyant air jet like an aerosol, the gravitational pull becomes dominant in the slower moving air with less turbulence, leading to gravitational fallout at a distance, thereby spraying objects like a neighbour patient bed or nurse workplaces, reaching on average even further than the large ballistic droplets, a finding that may be highly relevant because smaller droplets carry a significant amount of infectiosity.1 37 Unfortunately, this is also the particle size range where the nose, the primordial location of SARS-CoV-2 infection, catches particles highly effectively.38
While classical fluid dynamics, aerodynamics and droplet physics are well established scientific fields, it appears thus that in the complexities encountered in the interaction of human pathophysiology, viral spread, droplet physics and room air conditioning, some important and interesting phenomena are not yet fully explored, appear relevant for human health and thus merit further in-depth study that may contribute to solving urgent societal problems.
Hospital air conditioning
Air flow induced by A/C was an important driver of aerosol transmission to adjacent patients and nurse working locations and recirculation of contaminated air. Doors also played a role: typically, only a small minority of hospital rooms is equipped for negative pressure settings but default ventilation in our institution in patient rooms, builds up a slight positive pressure; when patient room doors remain open or are opened as needed for patient care, transfer of aerosols to the central nurse workplace occurred (data not shown). Increasing air flow rate beyond standard A/C settings on one side led to more aerosols removed from the room per time interval, but on the other side we found that it induced more turbulent room air flow at the given geometry as expected from fluid dynamics principles (Reynolds number in the turbulent regime), favouring air mixing and thus potentially transporting aerosol-loaded air from non-breathing zones towards breathing zones; therefore, the benefit of just increasing ventilation has limitations that depend on the specific characteristics of a room and A/C system.
Cough ‘shields’ were partly effective in stopping forward-directed cough droplets but led to a redirection of the air stream carrying aerosols, including in the direction of adjacent beds and nurse workplaces at the side of the patient bed, an effect which is not desired. Also, air flow around obstacles is a well-known physical phenomenon39 that limits the effectiveness of such shields for aerosol plumes, confirming and extending the finding of limited efficacy of face shielding alone on aerosol propagation.40
Air purification by filtering with a high flow, HEPA filter equipped commercially available air filtering device, was examined. We found in modelling as well as in real-world experiments (E-cigarette smoke distribution) that such an air filtering device alone, even when positioned near the patient head, only has a limited capabililty for directly and quantitatively removing droplets/aerosols from the cough jet because the jet velocities away from the device were sufficiently high to overcome the modest pressure/velocity gradient produced by the device. Non-patient-centred air filtering has been shown to contribute to reduction of overall aerosol load in recirculating contaminated room air,41 but in that setting, an aerosol concentration half-time in the range of 6–12 min was found, similar to the aerosol removal in our setting by standard A/C. In such devices, quantitative aerosol removal is dominated by air flow, directing flow towards the filter, rather than by device HEPA filter class (H13: 99.95%; H14: 99.995% particle removal efficacy).
Virus shield and sink—a novel, effective, per-patient airflow handling approach
To achieve near-complete elimination of droplets and aerosols of all sizes from 1 mm down to 0.1 µm from the cough jet and expired air, a novel per-patient airflow handling approach was designed, inspired by the findings above, and was validated in a real-life scenario.
Such a per-patient airflow management includes capturing large, ballistic, forward directed droplets by a shield that at the same time works as a jet redirector, limiting the forward velocity of the air jet and redirecting the aerosol plume in a way that it is amenable to being captured by a virus sink, a strategically placed air filtering device behind the patient’s head driven at velocities tailored to bend the streamlines of the aerosol jet towards the device and quantitatively filter the aerosol. This setup was capable to capture cough-related respiratory materials from millimetre-sized droplets down to submicron particles in a quantitative fashion.
E-cigarette smoke test as simple surrogate test for source control measures
The efficacy a specific Shield and Sink setup tailored to a specific location and filter device that may differ in geometry and air flow capacity from the one described here is amenable to simple qualitative function testing by the E-cigarette smoke test described here, thus representing a real-world quality control and training tool.
Clinical proof of infection reduction by preventive measures will require large-scale clinical trials that cannot easily be blinded. In the ongoing COVID pandemic, time available for such trials is limited, and clinical trial evidence for most prevention activities will remain sparse. As the approach proposed here is non-invasive, is associated with limited expense, and the current study focuses on a plausible surrogate marker, namely spread of various-sized materials produced by coughing, such a strategy may be clinically introduced with little delay, yielding a safe time window to further in-depth study of the still controversial role of aerosols in COVID transmission by additional methods, for example, aerosol nucleic acid testing and cell culture infectiosity of exhaled materials.
The novel Virus Shield and Sink approach for source control of droplets, jet riders and aerosols emitted by coughing patients permits significant reduction of the transfer of such potentially infectious materials in) a hospital setting. As a rapidly and inexpensively implementable infrastructural measure, it has the potential of contributing to mitigation and control of the COVID-19 pandemic. The proposed approach may complement and enhance overall protection achieved by standard measures like face masks that are not fully protective,42 and may also prove useful in settings where wearing full PPE by every person in a room is not feasible.
Data availability statement
Data are available upon reasonable request.
Patient consent for publication
This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.
This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.
Contributors PH has performed all the work included in the paper.
Funding The author has not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
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