Article Text

Download PDFPDF

Original research
Evaluation of patient characteristics, management and outcomes for COVID-19 at district hospitals in the Western Cape, South Africa: descriptive observational study
  1. Robert James Mash1,
  2. Mellisa Presence-Vollenhoven1,2,
  3. Adeloye Adeniji1,3,
  4. Renaldo Christoffels4,2,
  5. Karlien Doubell1,3,
  6. Lawson Eksteen1,3,
  7. Amee Hendrikse2,
  8. Lauren Hutton1,3,
  9. Louis Jenkins1,3,
  10. Paul Kapp1,3,
  11. Annie Lombard1,2,
  12. Heleen Marais2,
  13. Liezel Rossouw4,2,
  14. Katrin Stuve5,2,
  15. Abi Ugoagwu4,2,
  16. Beverley Williams1,3
  1. 1Family Medicine and Primary Care, University of Stellenbosch, Stellenbosch, Western Cape, South Africa
  2. 2Metro Health Services, Western Cape Provincial Government, Cape Town, South Africa
  3. 3Rural Health Services, Western Cape Provincial Government, Cape Town, South Africa
  4. 4Family Medicine, University of Cape Town, Cape Town, Western Cape, South Africa
  5. 5Internal Medicine, University of Stellenbosch, Stellenbosch, Western Cape, South Africa
  1. Correspondence to Professor Robert James Mash; rm{at}


Objectives To describe the characteristics, clinical management and outcomes of patients with COVID-19 at district hospitals.

Design A descriptive observational cross-sectional study.

Setting District hospitals (4 in metro and 4 in rural health services) in the Western Cape, South Africa. District hospitals were small (<150 beds) and led by family physicians.

Participants All patients who presented to the hospitals’ emergency centre and who tested positive for COVID-19 between March and June 2020.

Primary and secondary outcome measures Source of referral, presenting symptoms, demographics, comorbidities, clinical assessment and management, laboratory turnaround time, clinical outcomes, factors related to mortality, length of stay and location.

Results 1376 patients (73.9% metro, 26.1% rural). Mean age 46.3 years (SD 16.3), 58.5% females. The majority were self-referred (71%) and had comorbidities (67%): hypertension (41%), type 2 diabetes (25%), HIV (14%) and overweight/obesity (19%). Assessment of COVID-19 was mild (49%), moderate (18%) and severe (24%). Test turnaround time (median 3.0 days (IQR 2.0–5.0 days)) was longer than length of stay (median 2.0 day (IQR 2.0–3.0)). The most common treatment was oxygen (41%) and only 0.8% were intubated and ventilated. Overall mortality was 11%. Most were discharged home (60%) and only 9% transferred to higher levels of care. Increasing age (OR 1.06 (95% CI 1.04 to 1.07)), male (OR 2.02 (95% CI 1.37 to 2.98)), overweight/obesity (OR 1.58 (95% CI 1.02 to 2.46)), type 2 diabetes (OR 1.84 (95% CI 1.24 to 2.73)), HIV (OR 3.41 (95% CI 2.06 to 5.65)), chronic kidney disease (OR 5.16 (95% CI 2.82 to 9.43)) were significantly linked with mortality (p<0.05). Pulmonary diseases (tuberculosis (TB), asthma, chronic obstructive pulmonary disease, post-TB structural lung disease) were not associated with increased mortality.

Conclusion District hospitals supported primary care and shielded tertiary hospitals. Patients had high levels of comorbidities and similar clinical pictures to that reported elsewhere. Most patients were treated as people under investigation. Mortality was comparable to similar settings and risk factors identified.

  • COVID-19
  • accident & emergency medicine
  • respiratory infections

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See:

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Strengths and limitations of this study

  • The whole study population was included over a 4-month period at the height of the epidemic from eight district hospitals with few missing records.

  • A comprehensive dataset on presentation, assessment, management and outcomes was captured.

  • The size of the study population enabled identification of risk factors associated with mortality.

  • Data were dependent on the accuracy of medical records and clinical skills.

  • District hospitals without family physicians may have different quality of care, which limits generalisability.


COVID-19 is a global pandemic that has affected all regions of the world, although Africa has so far been less affected than predicted.1 Given the number of low- and middle-income countries, and relatively weak health systems, the pandemic is expected to significantly impact African communities.2 Within the African continent, South Africa has had the most reported cases and the Western Cape has been one of the leading hotspots.1 3

Clinical findings among confirmed COVID-19 cases in China showed the most common complaints were fever (83%), cough (82%), difficulty breathing (31%), fatigue and myalgia (11%).4 Non-respiratory injury was identified by elevated levels of aspartate aminotransferase (20%), creatinine (6%) and creatine kinase (15%).5

Findings from another Chinese study showed that older patients and those with comorbidity had poorer clinical outcomes.5 Multimorbidity was also correlated with poorer clinical outcomes.6 Comorbidity with cardiopulmonary diseases was a particular concern, such as diabetes, hypertension, asthma and chronic obstructive pulmonary disease (COPD). In South Africa, there was also concern with regard to the large numbers of people with HIV, particularly those who were immunocompromised, due to no or inadequate antiretroviral treatment. South Africa has 20% of all people living with HIV in the world and this is accompanied by a high incidence of tuberculosis (TB).7 8 Patients with active TB or post-TB structural lung damage were also a concern in our context.

Most clinical research has focused on tertiary hospitals with high-care or intensive care units (ICU). Little is known, therefore, about the types of patients seen at district hospitals and their clinical course with the expertise and equipment available at this level of the health system and in this African context. In South Africa, district hospitals usually have <150 beds and are run by generalists with male, female, maternity and paediatrics wards as well as emergency centres (EC). They are the first referral point, particularly in remote and rural areas, for patients from primary care.

In Africa, primary or district hospitals do not provide intensive or critical care and have limited capacity for prolonged ventilation. At the same time, tertiary referral hospitals may not be able to receive patients if their ICU facilities are full or they are very distant. Elsewhere in Africa it has been suggested that district hospitals should focus more on the provision of oxygen therapy as a more valuable intervention than ventilation, as ventilation requires adequate equipment and expertise, with a risk of harm to the patient and transmission of the virus during intubation.9 Guidelines have also been put in place to determine which patients should be prioritised for ICU and which critically ill patients should be managed with oxygen and if necessary palliative care.10 In June 2020, Cape Town also opened field hospitals, which had the ability to manage patients with COVID-19 at a level of care similar to a district hospital.11

This study will describe the type of patients referred to district hospitals run by family physicians in the Western Cape and evaluate their presentation, clinical management and outcomes. This data will help to provide a more complete picture of how COVID-19 is affecting our population as the patient population seen at district hospitals is different to that seen at tertiary hospitals and African populations may differ from those in Europe, Asia or America.

The aim of this study, therefore, was to describe the characteristics, clinical management and outcomes of patients with COVID-19 presenting to district hospitals in the Western Cape from March 2020 to June 2020. The specific objectives were to describe the original source of referral, the presenting symptoms, the patients’ demographics, the presence of comorbidities, the clinical assessment and management, the turnaround time (TOT) for laboratory results, the clinical outcomes and factors related to mortality, the length of stay and to compare district hospitals in rural health services (RHS) and metro health services (MHS).


Study design

This was a descriptive observational cross-sectional study by means of a retrospective audit of medical records.


The Western Cape had 33 district hospitals: 28 small (<150 beds), 3 medium (150–299 beds) and 2 large (300–600 beds). Small district hospitals in this study operated as generalist environments with family physicians as the most senior clinicians (one district hospital had an internal medicine physician running their inpatient COVID-19 ward). A family physician is a specialist in family medicine. In South Africa, family physicians are trained for the district hospital setting as well as primary care.

In terms of the continuum of care for COVID-19, these district hospitals received patients from the public sector primary care facilities in their catchment area. The private sector could also refer patients, without insurance, to the district hospitals. Patients in primary care, with more than mild symptoms, were referred for further management, although those requiring critical or intensive care could be referred directly to regional or tertiary hospitals. Therefore, the profile of patients seen and treated at district hospitals will be different to those referred to regional and tertiary hospitals as the capacity for critical care and intensive care was much less or non-existent. These small district hospitals typically had ECs and re-organised their wards into ‘hot’ and ‘cold’ streams for COVID-19. Patients could be intubated and ventilated in the EC, prior to transfer, and there was not usually access to high flow oxygen, which was only installed in June in some hospitals. District hospitals could discharge patients to home, transfer them to a field hospital or to higher-level care.

Study population and selection of participants

The study engaged the Stellenbosch University Family Physician Research Network and the family physicians within that network who worked at small district hospitals in the province. Eight district hospitals, four from the MHS in Cape Town and three in the RHS, opted to take part. The study excluded medium-large metropolitan district hospitals that were organised along specialist departmental lines and which delivered a different package of care. George Regional Hospital was also included in the RHS, as its Department of Family Medicine offered district hospital services to the surrounding area and ran the EC.

From these eight facilities, all patients who presented to the EC and who tested positive for COVID-19 were included between March and June 2020. There was no sampling or other exclusion criteria.

Data collection

Patients were identified from the laboratory results and their folders drawn from the records department. Data were extracted from the medical records using a standardised data collection tool by the family physicians at each hospital. Data were collected electronically using REDCap software on internet-connected devices available to the researchers. Overweight and obesity were defined as a body mass index >25 kg/m2. The South African Triage Scale was used by clinicians where red is for an immediate emergency, orange is very urgent, yellow is urgent and green is non-urgent.12 COVID-19 was classified according to clinical guidelines issued by the Western Cape Government: Health.13

The data collection tool was designed to collect data on the objectives listed above and the tool was validated by all the family physicians involved in the study prior to data collection. The tool was piloted by one district hospital prior to use.

Data analysis

Data were exported from REDCap to the Statistical Package for Social Sciences V.26. There was no missing data. Means with SD were used to describe continuous variables that were normally distributed and medians with IQRs to describe continuous data that were not normally distributed. Categorical data were analysed using frequencies and percentages.

Categorical variables were compared by Pearson’s χ2 test. An independent T-test was used to compare continuous variables with binary variables if data were normally distributed and a Mann-Whitney U test if data were not normally distributed. Analysis of variance was used to compare nominal variables with normally distributed numeric variables.

Univariate binary logistic regression was used to determine ORs for factors that might be associated with mortality (age, sex, comorbidities and location). Factors with a p value <0.1 were then entered into a multiple variable forward stepwise binary logistic regression to determine which factors remained significantly associated with mortality.

Patient and public involvement

Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.


Study sample

Overall, 1376 patients were included in the study for this period and 1017 (73.9%) were from the MHS and 359 (26.1%) from RHS. The mean age of patients was 46.3 years (SD 16.3 years) and patients were significantly older in the MHS compared with RHS (MHS 48.1 years (SD 16.1), RHS 41.4 years (SD 15.7), mean difference 6.73 years (4.80–8.66), p<0.001). Overall, there were 571 (41.5%) males and 805 (58.5%) females. There were significantly more females in the MHS sample than RHS (60.9% vs 51.8% female, p=0.003).

Presentation and assessment

Table 1 shows the characteristics of patients on arrival at the EC. Only 10% of patients were referred from public sector primary care facilities and the majority (70.6%) were self-referred. Patients were significantly more likely to be referred from a primary care facility in the RHS as shown in table 1.

Table 1

Characteristics of patients on arrival at the EC

The most common symptoms were cough, shortness of breath, fever, body pains/myalgia and sore throat. The most common abnormal clinical signs were a raised respiratory rate, tachycardia, hyperglycaemia, decreased oxygen saturation and raised systolic blood pressure. The impression was that MHS patients were sicker (more dyspnoea, lower oxygen saturation, more confused) than those in the RHS at presentation and RHS patients had more symptoms from an earlier phase of the disease (sore throat, myalgia, nasal symptoms, cough).

Table 2 presents the comorbidities of patients. A third of patients had no known comorbidities. The most common comorbidities were hypertension, type 2 diabetes, overweight/obesity and HIV. Patients in the MHS had significantly more comorbidities than those in the RHS. On arrival the levels of prior control for many comorbidities was unknown, particularly in the rural areas. People with type 2 diabetes had the highest proportion that were uncontrolled.

Table 2

Comorbidities of patients with COVID-19

Table 3 presents the initial assessment and final disposition from the EC. There was some mismatch between the initial triage and final assessment, with 53.1% of patients triaged as yellow and 17.1% of patients triaged as orange, being clinically assessed as mild COVID-19, and half (49.1%) of all patients were assessed as mild. Patients from the RHS were significantly more likely to be assessed as mild and less likely to be admitted. Overall, 42.2% were discharged home from the EC, 47.4% admitted and only 6.2% transferred immediately to a higher level of care.

Table 3

Initial assessment and disposition from the emergency centre

Management in hospital

Most patients were admitted as people under investigation and managed without a definitive diagnosis, as the TOT for the test result (median 3.0 days (IQR 2.0–5.0 days)) was longer than the length of stay (median 2.0 day (IQR 2.0–3.0)). There was no difference in the TOT between MHS and RHS (MHS median 3.0 days (IQR 3.0–4.0) and RHS 2.0 days (IQR 2.0–3.0), p=0.113).

Half of all patients did not receive a chest radiograph in the EC or on admission (695 (50.5%)) and this was significantly more likely in rural areas (MHS 41.9% vs RHS 74.7%, p<0.001). The typical appearance was bilateral changes in the lower or mid-zone, a ground glass appearance or consolidation. There were no major differences in the radiograph findings between MHS and RHS.

Table 4 presents the treatments for COVID-19. Only 40.6% received any form of oxygen therapy and very few were intubated (0.8%). Those admitted were usually treated with oxygen, low molecular weight heparin (enoxaparin sodium) and antibiotics (ceftriaxone, azithromycin or co-amoxiclav) and far fewer patients were treated with proning or steroids. Proning was only used in 24% of those with severe or critical COVID-19.

Table 4

Treatment received at the district hospital

Table 5 presents the final clinical outcomes. The overall mortality rate was 11.0% and 19.6% for those admitted. Mortality rose to 57.3% for those that were critically ill, 21.8% for severe cases, 7.5% for moderate cases and 1.8% for mild. Half of those admitted were discharged home (49.7%) and only 8.7% were transferred to a higher level of care and this was significantly more likely in the MHS (p<0.001). The MHS also made use of the field hospitals.

Table 5

Clinical outcomes at the district hospitals

Risk factors for mortality

In the multiple variable analysis, increasing age, male sex, overweight/obesity, type 2 diabetes, chronic kidney disease, cardiac failure, HIV and treatment for cancer were all independently associated with a higher risk of death (table 6). Chronic respiratory conditions, such as asthma, COPD, post-TB lung damage and tobacco smoking were not associated with increased risk of mortality. Hypertension and hypercholesterolaemia were also not retained as risk factors in the multiple variable analysis. There was no difference in risk of mortality between the MHS and RHS. In addition, there was a significant relationship between poorer categories of diabetic control and mortality (OR 2.28 ((95% CI 1.25 to 4.16), p=0.007), but not with poor control of HIV (unsuppressed viral load) (OR 1.96 (95% CI 0.62 to 6.23), p=0.253). There was also no significant relationship with being on antiretroviral treatment (OR 0.879 (95% CI 0.524 to 1.48), p=0.627).

Table 6

Risk factors for death from COVID-19


Contribution of district hospitals to the health system response

The majority of people with COVID-19 were self-referred and bypassed the gatekeeping role expected of public sector primary care facilities. Primary care facilities are often closed on weekends and afterhours making the district hospital EC the next available point of access. Primary care facilities also de-escalated during the epidemic and people were turned away or advised to stay away as much as possible,14 while there was no restrictions on access to district hospitals. In some areas, primary care facilities temporarily closed when staff were infected. Although primary care facilities could test, the district hospitals had larger and more visible testing centres. This, in addition to fear of more severe disease and more trust in hospital-based services, may have led people to present directly to the hospital. In rural areas, where the hospital was more geographically distant, more people entered the system via primary care facilities. District hospitals, therefore, played an important role in primary care during the epidemic and this is reflected in the findings that 49% of patients seen had mild COVID-19% and 42% were immediately discharged home from the EC. This also reflects the need to improve access to primary care in South Africa.15

District hospitals reduced pressure on tertiary hospitals with ICU and critical care beds particularly for those with moderate and severe COVID-19. Of those with moderate COVID-19, only 9% were transferred to tertiary hospitals and mortality was 7.5%. For those with severe disease, 17% were transferred and mortality was 22%, which compares favourably with reports from high-income settings.16 District hospitals were unable to manage critically ill patients, as they did not have ICU or critical care facilities.

The introduction of field hospitals, such as at the Cape Town International Convention Centre,17 also took pressure off acute hospitals and 13.5% of patients were transferred for ongoing care thus creating additional capacity at the district hospital. The first field hospital only opened in June 2020, the last month of this study period. At the field hospital, care might include management of comorbidities, palliative care or further recovery prior to discharge home.17

The differences between RHS and MHS appeared to represent differences in the type of patients and geographic access rather than health services. RHS appeared to have younger patients, more often referred by local primary care facilities, with fewer comorbidities and less severe disease, which translated into lower mortality and better outcomes. In the Western Cape, the rural district hospitals had good infrastructure, equipment and competent clinical teams led by family physicians.

No other studies were found reporting on district hospitals from low-income and middle-income countries. The few studies from the UK reporting on district hospitals are not comparable as these hospitals offer specialist services and serve a different type of population.18 District or primary hospitals in our setting are small, often rural or remote, and led by generalists or family physicians. These types of hospitals are rare in high-income countries, but an important part of African health systems. Although district hospitals in the Western Cape are generally well resourced and led by family physicians, in other parts of Africa these hospitals may have significant skills, equipment and infrastructure gaps.19 African populations are also younger and have a different profile of comorbidities with communicable diseases more prominent (such as HIV, TB and malaria). Poverty is also a major issue that impacts on access to healthcare as well as food security and malnutrition.19 It is therefore important to evaluate how people with COVID-19 are managed and what their outcomes are at this level of African health systems.

Management of COVID-19 at district hospitals

Patients presented with the typical symptoms of COVID-19 that have also been reported elsewhere in Africa.20 Fever, however, was only found in 12% of patients and many patients had hyperglycaemia and high blood pressure, reflecting underlying comorbidities. Family physicians reported that the procedures to use infrared thermometers to triage patients may not have resulted in accurate measurements and therefore fever may be underobserved.21 Not all patients had a body mass index measured and overweight/obesity was probably under-reported.

As the median TOT for COVID-19 tests was longer than the median length of admission, most patients were managed as people under investigation, who were presumed to have COVID-19. The laboratory capacity and TOT for COVID-19 tests has been labelled ‘the Achilles heel’ of the local response to the pandemic.22 The in-hospital TOT improved once the criteria for community testing were changed, from all people with relevant symptoms to only those over 55 years or with comorbidities or with more than mild disease.23

Antibiotics were presumably given as the diagnosis was not confirmed in the majority of patients and the patient were treated as a community-acquired pneumonia with COVID-19 as part of the differential diagnosis. Steroids were only given in 28% of patients, but the evidence of their effectiveness were only announced in June 2020,24 which was the last month of this study period.

Basic imaging with a chest radiograph was only performed in half the patients, which mirrors the large number of mild cases who did not require imaging. All district hospitals had access to radiography, although not always 24 hours a day and in some cases the clinician may have judged that management of the patient would not be changed. In addition, radiography might have been avoided in order to reduce exposure of people to COVID-19 as patients would have to traverse the hospital to access the radiography unit if a mobile radiograph was not available. Not all critically ill received a radiograph and this might be because they died before a radiograph could be taken or were transferred. Patients were referred on the basis of the clinical picture and a radiograph was not essential.

Clinical outcomes at district hospitals

Overall in-hospital mortality for COVID-19 was 11% and rose to 20% in those admitted. Mortality was significantly higher in MHS facilities compared with RHS and this most likely reflects the higher severity of patients, rather than differences in management of patients. Mortality rates reported from a field hospital in Ethiopia were much lower (5.3%) despite a similar profile of COVID-19 severity in those seen.25 This may be explained by much lower levels of comorbidity. For example, no HIV or TB was reported and diabetes was found in 14% as opposed to 25% of patients.

A local population cohort study also found an association between people living with HIV and mortality from COVID-19 and no clear association with viraemia or immunosuppression.26 However, in district hospitals we found no association with previous or current TB infection and mortality from COVID-19, while the population cohort study found a twofold increase. The population study may have overestimated risks as routine data did not include all comorbidities and these patients were more likely to be followed up and diagnosed with COVID-19. Other respiratory conditions such as asthma, COPD and post-TB structural lung disease were also not associated with increased mortality. This could suggest that immunological factors were maybe more important than pulmonary factors in determining risk of death. Other conditions with impaired or altered immunity were also associated with mortality, such as type 2 diabetes and people receiving treatment for cancer.

The combination of increasing age, overweight/obesity, type 2 diabetes, chronic kidney disease and cardiac failure as independent risk factors is important as one in two South Africans over the age of 45 years have prediabetes or diabetes.27 Increasing age, obesity and chronic kidney disease were also identified as key risk factors in the Democratic Republic of Congo28 and diabetes in Ethiopia. The importance of non-communicable diseases, such as diabetes, was brought into the public spotlight by COVID-19 as previously the focus of attention was on HIV and TB. The level of control of diabetes was also directly related to risk of mortality, which emphasised the need to improve self-management and treatment, particularly as 57% had a history of poor control on admission. The absence of electronic medical records and an integrated health information system explains why hospitals could not obtain information on prior control of chronic diseases, particularly in the RHS. The continuity of care for type 2 diabetes was also disrupted by the de-escalation of services and most forms of patient education and counselling were stopped. There is a need to innovate new ways of managing and empowering people with diabetes while reducing their risk of exposure to COVID-19 at health facilities and support groups.

All results were dependent on the completeness and accuracy of medical records. For example, clinicians may not have recorded all the symptoms experienced by the patients. Family physicians did not report a problem with missing medical records. It would have been helpful to record the antiretroviral treatment regimen in patients with HIV and to investigate any association between mortality and exposure to different combinations of medications. No data were collected on laboratory results such as full blood count, urea or creatinine or on the time between onset of symptoms and treatment, and this might have been useful to investigate the relationship with clinical outcomes. It was not possible to determine the outcomes of patients that were discharged from the EC with mild disease and it is possible that some were re-admitted to other hospitals. None of the family physicians collecting data reported that patients in the study were re-admissions.

These hospitals all had family physicians heading their clinical teams and it is possible that they had a higher quality of care than the hospitals that are still without them. The Western Cape also has better infrastructure and a stronger health system than many other provinces and the quality of care is likely to be lower in other parts of South Africa.


District hospitals provided an essential primary care service for many patients with mild symptoms of COVID-19 during the epidemic. This also represented a deficiency in access to and utilisation of primary care. District hospitals successfully treated a large number of people with moderate-to-severe COVID-19 who did not need ventilation and took pressure off higher-level facilities. Limited laboratory capacity meant that most patients were treated as people under investigation without a definitive diagnosis. The clinical picture was similar to that reported elsewhere. Mortality at this level of care was associated with increasing age, male sex, HIV, type 2 diabetes, overweight/obesity, cardiac failure, chronic kidney disease and treatment for cancer, but not with hypertension, TB, asthma, COPD or post-TB lung damage. Patients in the MHS were more numerous, had more comorbidity and more severe COVID-19 disease than in the RHS.



  • Twitter @Adeniji charles Ade

  • Contributors RJM and MP-V conceptualised the study. All authors approved the study proposal. MP-V, AH and HM collected data at Eerste River Hospital; AL and KS collected data at Helderberg Hospital; AU and RC collected data at Wesfleur Hospital; LR collected data at False Bay Hospital; LJ collected data at George Hospital; LH and PK collected data at Knysna Hospital; LE and BW collected data at Stellenbosch Hospital; AA and KD collected data at Ceres Hospital. RJM analysed the data. All authors gave feedback on their interpretation of the results. RJM and MP-V wrote the draft manuscript. All authors gave feedback on the manuscript and approved the final version.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the Health Research Ethics Committee at Stellenbosch University (N20/06/032_COVID-19) who granted a waiver of informed consent for collection on anonymised data from medical records. Study permission was obtained from the Provincial Government of the Western Cape to conduct the study.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement Data are available on reasonable request. De-identified participant data are available on reasonable request from the first author Professor Robert Mash