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Clinical risk score to predict in-hospital mortality in COVID-19 patients: a retrospective cohort study
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  • Published on: 8 December 2020
    Thrombocytopenia in COVID-19 patients

    Fumagalli et al. conducted a retrospective cohort study to develop a clinical risk score to predict the in-hospital mortality in COVID-19 patients ≥18 years [1]. Significant predictors of mortality were increasing age, number of chronic diseases, respiratory rate, decreasing PaO2/FiO2, serum creatinine and decreasing platelet count of mortality. I have come concerns about their study with special reference to thrombocytopenia in COVID-19 patients.

    There have been many meta-analyses of presenting severe health hazard of thrombocytopenia in COVID-19 patients. Three papers in British Journal of Haematology [2-4], two papers in European journal of Clinical Investigation [5,6], and one paper n Biomarker Research [7]. Although severe health hazards of thrombocytopenia in COVID-19 patients has been consistently reported by meta-analyses, a cohort study with minimum bias should also be conducted with special reference to comorbidity and aging.

    References
    1. Fumagalli C, Rozzini R, Vannini M, et al. Clinical risk score to predict in-hospital mortality in COVID-19 patients: a retrospective cohort study. BMJ Open. 2020 Sep 25;10(9):e040729.
    2. Zhou M, Qi J, Li X, et al. The proportion of patients with thrombocytopenia in three human-susceptible coronavirus infections: a systematic review and meta-analysis. Br J Haematol. 2020 May;189(3):438-441.
    3. Jiang SQ, Huang QF, Xie WM, et al. The association between severe COVID-19 and low platelet count: eviden...

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    Conflict of Interest:
    None declared.