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Immunology (including allergy)
Protocol
Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy (PPOIT) in inducing desensitisation or tolerance in children with peanut allergy compared with oral immunotherapy (OIT) alone and with placebo (the PPOIT-003 study)

Authors

  • Adriana Chebar Lozinsky Allergy Immunology, Murdoch Children's Research Institute, Parkville, Victoria, Australia PubMed articlesGoogle scholar articles
  • Paxton Loke Allergy Immunology, Murdoch Children's Research Institute, Parkville, Victoria, AustraliaAllergy and Immunology, Royal Children's Hospital, Melbourne, Victoria, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Francesca Orsini Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, Parkville, Victoria, AustraliaClinical Epidemiology and Biostatistics Unit, Melbourne Children's Trial Centre, Murdoch Children's Research Institute, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • Michael O’Sullivan ORIGINS Project, Telethon Kids Institute, Nedlands, Western Australia, AustraliaDivision of Pathology and Laboratory Medicine, School of Medicine, University of Western Australia, Crawley, Western Australia, AustraliaAllergy, Immunology and Dermatology, Perth Children's Hospital, Nedlands, Western Australia, Australia PubMed articlesGoogle scholar articles
  • Susan L. Prescott ORIGINS Project, Telethon Kids Institute, Nedlands, Western Australia, AustraliaAllergy, Immunology and Dermatology, Perth Children's Hospital, Nedlands, Western Australia, AustraliaDivision of Paediatrics, School of Medicine, University of Western Australia, Perth, Western Australia, Australia PubMed articlesGoogle scholar articles
  • Michael S Gold Paediatrics, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, AustraliaAllergy and Immunology, Women’s and Children’s Hospital, North Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Patrick Quinn Paediatrics, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, AustraliaAllergy and Immunology, Women’s and Children’s Hospital, North Adelaide, South Australia, Australia PubMed articlesGoogle scholar articles
  • Audrey DunnGalvin School of Applied Psychology, University College Cork, Cork, IrelandInstitute of Child Health, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia PubMed articlesGoogle scholar articles
  • Mimi LK Tang Allergy Immunology, Murdoch Children's Research Institute, Parkville, Victoria, AustraliaAllergy and Immunology, Royal Children's Hospital, Melbourne, Victoria, AustraliaDepartment of Paediatrics, University of Melbourne, Melbourne, Victoria, Australia PubMed articlesGoogle scholar articles
  • on behalf of the PPOIT study team
    Google scholar articles
  1. Correspondence to Dr Mimi LK Tang; mimi.tang{at}rch.org.au
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Citation

Chebar Lozinsky A, Loke P, Orsini F on behalf of the PPOIT study team, et al
Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy (PPOIT) in inducing desensitisation or tolerance in children with peanut allergy compared with oral immunotherapy (OIT) alone and with placebo (the PPOIT-003 study)
BMJ Open 2020;10:e035871. doi: 10.1136/bmjopen-2019-035871

Publication history

  • Received November 20, 2019
  • Revised June 4, 2020
  • Accepted July 16, 2020
  • First published September 9, 2020.
Online issue publication 
September 09, 2020
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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.